Xios University College

Diepenbeek, Belgium

Xios University College

Diepenbeek, Belgium
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Broeders J.,Hasselt University | Broeders J.,Xios University College | Croux D.,Hasselt University | Peeters M.,Hasselt University | And 9 more authors.
IEEE Sensors Journal | Year: 2013

A new method is presented for smartphone-based impedance spectroscopy, especially fine-tuned for biomimetic sensor readout. Complete user control is given by means of an app while the on-board audio hardware of the smartphone or tablet PC is used to perform impedance measurements. This considerably limits the required external hardware. Disposable test strips can be mounted for convenient readout of various sensors. The system is verified on passive components and a synthetic molecularly imprinted polymer histamine sensor. The prototype design could prove a useful step toward the development of home-diagnostics biosensing applications. © 2001-2012 IEEE.

Broeders J.,Hasselt University | Broeders J.,Xios University College | Duchateau S.,Xios University College | Van Grinsven B.,Hasselt University | And 8 more authors.
Physica Status Solidi (A) Applications and Materials Science | Year: 2011

A miniaturised, low cost impedance analyser is developed to ease the use of impedance spectroscopy in biological setups. This could form the first step towards fully standalone, hand-held biosensor applications. The system is capable of performing quasi-simultaneous time resolved impedance measurements on eight different channels in a frequency range of 10Hz-100kHz. The unit is accurate in a broad impedance range and is able to perform stable measurements over intervals of several days. The system is characterised by passive components, a temperature controlled wet cell based impedance setup and a biomimetic molecularly imprinted polymer (MIP) based histamine sensor. The test results all indicate accurate and stable functioning of the unit, making it suitable for bioanalytical applications. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Duchateau S.,Xios University College | Duchateau S.,Hasselt University | Broeders J.,Xios University College | Broeders J.,Hasselt University | And 9 more authors.
Physica Status Solidi (C) Current Topics in Solid State Physics | Year: 2013

Cell proliferation can be monitored by a wide range of well-established techniques. Most of the principles used rely on optical, single end-point methods, often involving the use of absorbent, fluorescent or luminescent compounds. These additives can interfere with the cell growth, thus producing distorted results. Electrochemical impedance spectroscopy provides a solution for this problem and enables continuous monitoring without interference. However equipment for this measurement technique is often bulky, highly expensive and lacks multichannel features. This paper presents a low-cost, compact hardware platform optimized for proliferation measurements, together with custom software to ease interpretation and physical modelling of data. Performance is demonstrated and measurement parameters are fine-tuned for three commonly used cell types in proliferation measurements. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Baleviciute I.,Vilnius University | Ratautaite V.,Vilnius University | Ramanaviciene A.,Vilnius University | Balevicius Z.,Lithuanian Academy of Sciences | And 12 more authors.
Synthetic Metals | Year: 2015

Abstract In this study some affinity and dielectric properties of molecularly imprinted (MIP) conducting polymer - polypyrrole (Ppy) based thin films were evaluated. Films of polypyrrole molecularly imprinted with theophylline (MIP-Ppy) and non-imprinted polypyrrole (NIP-Ppy) were formed on boron doped silicon (Si) substrates in order to evaluate the efficiency of Ppy to bind theophylline. The substrates were modified with boron-doped oxygen terminated nanocrystalline diamond (B:NCD:O) The dielectric properties of B:NCD:O/Ppy-based multi-layered structures were analyzed using spectroscopic ellipsometry and spectrophotometric techniques. Electrochemical impedance spectroscopy was applied for the investigation of kinetics of theophylline interaction with MIP-Ppy and NIP-Ppy. The sensitivity of molecularly imprinted and non-imprinted polymer films was analyzed by injection of different theophylline concentrations. Assuming that Ppy film electrical capacitance change is a result of Ppy dielectric constant change induced by absorbed theophylline molecules, the electrical capacitance change (ΔC) kinetics at different concentrations of theophylline was analyzed using first pseudo order kinetic equation. The dissociation equilibrium constant KD of MIP-Ppy/theophylline complex at room temperature was calculated as 1.7 × 10-8 M, and Gibbs free energy change (ΔG) of MIP-Ppy/theophylline complex formation was calculated as -43.5 kJ/mol. It was concluded that molecularly imprinted polypyrrole thin film could be used for the detection of theophylline. © 2015 Elsevier B.V.

Croux D.,Hasselt University | Vangerven T.,Hasselt University | Broeders J.,Hasselt University | Broeders J.,Xios University College | And 13 more authors.
Physica Status Solidi (A) Applications and Materials Science | Year: 2013

Molecular imprinted polymer (MIP) sensors offer a high potential in the development of cheap small-scale disposable biomimetic sensors. Molecular imprinting leads to the formation of inert polymer particles with nanocavities, which can exhibit similar selectivity and specificity to target molecules as antibodies or enzymes. These sensors open up many possible applications in the field of mass-market consumer products such as food packaging sensors. One such application is the detection of histamine in spoiled fish, which causes scombroid poisoning, a common seafood poisoning. This contribution provides one possible solution for easing the use of these sensors in field applications. A screen-printed short-range wireless MIP-based biosensor based upon passive radio frequency identification (RFID) tags was developed as a proof of principle. Histamine molecules binding to an MIP recognition layer induce a dielectric change in the sensor capacitance, resulting in a resonance frequency shift that is transmitted by inductive coupling. This wireless sensor is capable of detecting histamine concentrations as low as 50 nM at a range of a few centimeters. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Broeders J.,Hasselt University | Croux D.,Hasselt University | Weustenraed A.,Hasselt University | Cleij T.,Hasselt University | And 5 more authors.
Proceedings of the 14th IEEE International Conference on High Performance Computing and Communications, HPCC-2012 - 9th IEEE International Conference on Embedded Software and Systems, ICESS-2012 | Year: 2012

Bridging the gap between state of the art consumer electronics and bio-analytical setups designed for lab environments, an embedded, miniaturised, stand-alone measurement device is developed. The presented impedance analyser incorporates most of the data communication features present in current-generation smartphones and is specifically optimised for low-frequency impedance based biosensor readout. The compact unit operates fully stand-alone with a touchscreen. Its functionality was tested and verified. In this work the unit is tested by using a biomimetic sensing device for the detection of L-nicotine. The combination between the handheld, embedded design of this specialised measurement equipment and a sensor layout fine-tuned for specific applications could mean significant advances in point-of-care systems. © 2012 IEEE.

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