Entity

Time filter

Source Type


Objective: To investigate the expression of Rapl GTPase-activating protein 1 (RaplGAP), matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9), and their relation with clinical patterns in colorectal carcinoma. Methods: Immunohistochemistry was used to detect the expression of RaplGAP,MMP-2 and MMP-9 in colorectal carcinoma, villous adenoma, tubular adenoma and normal colorectal tissue, and their relationship with clinicopathological parameters was analyzed. Results: The positive rate of RaplGAP expression was 30.4 % (14/46), 77.8 % (14/18), 69.6 % (16/23) and 95.2 % (20/21) in colorectal carcinoma, villous adenoma, tubular adenoma, and normal colorectal tissue, respectively (Χ2 = 30.659, P= 0.000). The figures were 71.7 % (33/46), 55.6 % (10/18), 52.2 % (12/16) and 9.5 % (2/21) for the positive rate of MMP-2 expression (Χ2 = 22.459, P = 0.000), as well as for 76.1 % (35/46), 61.1 % (11/18), 56.5 % (13/23) and 14.3 % (3/21) for the positive rate of MMP-9 expression, respectively (Χ2 = 22.643, P = 0.000). In patients with colorectal carcinoma, the expression of RaplGAP was correlated with tumor differentiation (Χ2 = 5.275, P = 0.022), but not sex, age, or lymphatic metastasis (all P > 0.05). The expression of MMP-2 and MMP-9 were correlated with lymphatic metastasis (Χ2 = 6.661, P = 0.010; χ2 = 8.475, P = 0.040), but not sex, age or tumor differentiation (all P > 0.05). There was a negative correlation between expression of RaplGAP and MMP-2, MMP-9 in colorectal carcinoma,respectively (r = -0.424, P = 0.003; r = -0.294, P = 0.048), but no correlation between the expression of MMP-2 and MMP-9 (r = 0.101, P = 0.505). Conclusions: RaplGAP, MMP-2 and MMP-9 play important roles in the malignant biological behavior of colorectal carcinoma, and the expression of RaplGAP is negatively correlated with MMP-2 and MMP-9.The interactions among the three affect the occurrence and development of colorectal carcinoma.


Jin Y.,Xinzhou City Peoples Hospital
Cancer Research and Clinic | Year: 2013

Objective: To explore the expressions of ER, PR and CerbB-2 in human papillary thyroid carcinoma, and their correlation with the clinical features. Methods: The expressions of ER, PR and CerbB-2 were detected by immunohistochemistry in 89 papillary thyroid carcinoma samples and 13 nodular goiter samples. Results: In papillary thyroid carcinoma samples, ER, PR and CerbB-2 were detected for 50.56% (45/89), 43.82% (39/89), 24.72% (22/89), respectively. In nodular goiter, ER, PR and CerbB-2 were detected for 15.38% (2/13), 7.69% (1/13), 0, respectively, there were significant differences between the two groups (χ2 = 5.649, P = 0.017, χ2 = 6.211, P = 0.013, χ2 = 4.097, P = 0.043). The positive rates of PR were 56.26% (26/46) in without lymph node metastasis, compared with those lymph node metastasis 30.2 3% (13/43) were significantly higher, the difference was statistically significant (χ2 = 6.239, P = 0.012). Conclusion: The expressions of ER, PR and CerbB-2 are significant higher in papillary thyroid carcinoma. The detection of ER, PR and CerbB-2 might be helpful for early diagnosis and prognosis of papillary thyroid carcinoma.


Jin Y.,Xinzhou City Peoples Hospital
Cancer Research and Clinic | Year: 2013

Objective: To investigate the clinicopathological significance of periostin and MMP-2 in colorectal carcinoma. Methods: Immunohistochemistry was used to detect the expression of periostin and MMP-2 in colorectal carcinoma, tubular adenoma, villous adenoma and normal colorectal tissue. The correlations between the expression of periostin and MMP-2 with clinicopathologic parameters were analyzed. Results: In colorectal carcinoma, tubular adenoma, villous adenoma and normal colorectal tissue, the positive rates of periostin were 83.7% (41/49), 40.0% (6/15), 32.1% (9/28), 0 (0/15), respectively, while the positive rates of MMP-2 were 71.4% (35/49), 60.0% (9/15), 64.3% (18/28), 0(0/15), respectively. There were significant differences among the groups (χ2 = 41.252, P = 0.000; χ2 = 24.811, P = 0.000). The expression of periostin in colorectal carcinoma tissue were not correlated with sex (χ2 = 0.002, P = 0.961), age (χ2 = 2.267, P = 0.132), tumor sites (χ2 = 1.506, P = 0.220), differentiation status (χ2 = 0.875, P = 0.350) and lymphatic metastasis (χ2 = 3.315, P =0.069). The expression of MMP-2 in colorectal carcinoma were correlated with lymphatic metastasis (χ2 = 5.800, P = 0.016), whereas not correlated with sex (χ2 = 0.562, P = 0.453), age (χ2 = 0.138, P = 0.711), tumor sites (χ2 = 0.408, P = 0.532), differentiation degree (χ2 = 1.335, P = 0.248). The expression of periostin and MMP-2 were positively correlated in colorectal carcinoma (r = 0.332, P = 0.020). Conclusion: Periostin and MMP-2 are correlated closely with the development and progression of colorectal carcinoma. It might be helpful for evaluating the biological properties and prognosis of colorectal carcinoma, and it would be more accurate to use a combined analysis of the two indicators.


Pan Y.,Capital Medical University | Wang A.,Capital Medical University | Liu G.,Capital Medical University | Zhao X.,Capital Medical University | And 122 more authors.
Journal of the American Heart Association | Year: 2014

Background: Treatment with the combination of clopidogrel and aspirin taken soon after a transient ischemic attack (TIA) or minor stroke was shown to reduce the 90-day risk of stroke in a large trial in China, but the cost-effectiveness is unknown. This study sought to estimate the cost-effectiveness of the clopidogrel-aspirin regimen for acute TIA or minor stroke. Methods and Results: A Markov model was created to determine the cost-effectiveness of treatment of acute TIA or minor stroke patients with clopidogrel-aspirin compared with aspirin alone. Inputs for the model were obtained from clinical trial data, claims databases, and the published literature. The main outcome measure was cost per quality-adjusted life-years (QALYs) gained. Oneway and multivariable probabilistic sensitivity analyses were performed to test the robustness of the findings. Compared with aspirin alone, clopidogrel-aspirin resulted in a lifetime gain of 0.037 QALYs at an additional cost of CNY 1250 (US$ 192), yielding an incremental cost-effectiveness ratio of CNY 33 800 (US$ 5200) per QALY gained. Probabilistic sensitivity analysis showed that clopidogrel-aspirin therapy was more cost-effective in 95.7% of the simulations at a willingness-to-pay threshold recommended by the World Health Organization of CNY 105 000 (US$ 16 200) per QALY. Conclusions: Early 90-day clopidogrel-aspirin regimen for acute TIA or minor stroke is highly cost-effective in China. Although clopidogrel is generic, Plavix is brand in China. If Plavix were generic, treatment with clopidogrel-aspirin would have been cost saving. © 2014 The Authors.


Jin M.,Xinzhou City Peoples Hospital | Fu X.,Xinzhou City Peoples Hospital | Tian L.,Xinzhou City Peoples Hospital | Wang S.,Xinzhou City Peoples Hospital
Cancer Research and Clinic | Year: 2014

Objective: To investigate the expression and significance of Periostin, VEGF and MMP-9 in breast invasive ductal carcinoma. Methods: Immunohistochemistry was employed to detect the expression of Periostin, VEGF and MMP-9 in breast invasive ductal carcinoma and normal breast tissue. Results: In breast invasive ducted carcinoma and normal breast tissue ,the positive rates of Periostin were 63.8% (37/58) and 0 (χ2 = 24.272, P = 0.000). The figures were 69% (40/58) and 8% (2/25) for the positive rates of VEGF (χ2 = 25.977, P = 0.000), respectively, as well as 70.69% (41/58) and 16.0% (4/25) for the positive rates of MMP-9 (χ2 = 21.050, P = 0.000), respectively. There were significant differences among the groups (P < 0.05). In breast invasive ductal carcinoma, the expression of Periostin was correlated with clinical stage (χ2 = 4.835, P = 0.028), whereas not correlated with age (χ2 = 1.155, P = 0.282), histological grade (χ2 = 0.05, P = 0.972), lymphatic metastasis (χ2 = 1.660, P = 0.198). The expression of VEGF was correlated with clinical stage (χ2 = 4.230, P = 0.040), lymphatic metastasis (χ2 = 9.667, P = 0.002), whereas not correlated with age (χ2 = 0.506, P = 0.477), histological grade (x2 = 0.532, P = 0.767). The expression of MMP-9 was correlated with clinical stage (x2 = 8.456, P = 0.004), lymphatic metastasis (χ2 = 5.494, P = 0.019), whereas not correlated with age (χ2 = 0.153, P = 0.695), histological grade (χ2 = 0.224, P = 0.894). The expression of Periostin, VEGF and MMP-9 were positively correlated with each other in breast invasive ductal carcinoma (r = 0.348, P = 0.001; r = 0.303, P = 0.021; r = 0.469, P = 0.000). Conclusion: Periostin,VEGF and MMP-9 are correlated closely with the occurrence and development of breast invasive ductal carcinoma, which might be valuable in evaluating the invasiveness, metastasis and prognosis.

Discover hidden collaborations