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Zeng Z.,Nanchang University | Liao Q.,Peoples Hospital of Xinyu | Cai J.,Nanchang University | Liu A.,Nanchang University
Chinese Journal of Clinical Oncology | Year: 2012

Objectives: This study aims to evaluate the capability and reliability of diffusion-weighted imaging ( DWI ) in differentiating metastatic from non-metastatic mediastinal lymph nodes in patients with non-small cell lung cancer ( NSCLC ). Methods: Forty-five consecutive patients with pathologically confirmed NSCLC underwent echo-planar diffusion-weighted magnetic resonance imaging of the mediastinum with b-factors of 600, 800, and 1,000 s/mm 2. The apparent diffusion coefficient (ADC ) values of the mediastinal lymph nodes were calculated. The ADC values were correlated with the biopsy results. A value of P < 0.05 was considered statistically significant. Results: The mean ADC value of malignant mediastinal lymphadenopathy ( 1.73 mm 2/s± 0.24×10 -3 mm 2/s ) was significantly lower ( P < 0.05 ) than that of benign lymphadenopathy (2.67 mm 2/s ±0.16×10 -3 mm 2/s ). A significant difference in the ADC values was observed between metastatic and benign nodes ( P < 0.05 ). However, no significant difference in the ADC values was observed between the metastatic lymph nodes of different pathologies. Given an ADC value of 2.23 × 10 -3 mm 2/s as the threshold for differentiating malignant mediastinal nodes from the benign nodes, the best results were obtained with an accuracy of 82%, false negative rate of 31%, negative predictive value of 90%, and positive predictive value of 76% . The area under the curve was 0.96. Conclusion: DWI may be a feasible and reliable method to discriminate malignant mediastinal lymph nodes from benign nodes in patients with NSCLC.

Liu W.,Peoples Hospital of Xinyu | Liu W.,Nanchang University | Xie Y.,Nanchang University | Liu Z.-j.,Peoples Hospital of Xinyu
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Chitosan microspheres loading Helicobacter pylori whole cell protein antigen prepared by different methods have different the package rates and controlled-release effects. OBJECTIVE: To prepare chitosan microspheres loading Helicobacter pylori whole cell protein antigen and observe the release characteristics in vitro. METHODS: Berthold precipitation method was used to prepare chitosan microspheres and the preparation was optimized; scanning electron microscope and particle size analyzer were used to observe the shape and size measurement of chitosan micro spheres; the BCA Protein Assay Kit was used to measure the loading efficiency, loading capacity and releasing rate of microspheres. RESULTS AND CONCLUSION: We chose the best preparation program of chitosan microspheres from 32 species preparation programs: the best preparation program was the material of sea shell chitosan, 1% concentration of acetic acid, sodium sulfate for precipitating agent and 5.0 pH value, non-use of ultrasonic treatment. SEM results showed that the microspheres presented with smooth round and dense, diameters ranged from 1.0 um to 5.0 um; Antigen loading efficiency was 79.92%, loading capacity was 16.47%; Release experiment in vitro showed that the total antigen releasing rate was 20.39%, showing a slow-release status.

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