Xinyu, China
Xinyu, China

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Ruan Z.-Y.,Xinyu Peoples Hospital | Huang J.-L.,Xinyu Peoples Hospital | Luo C.-F.,Shanghai JiaoTong University
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: The CT image is better than X-ray plain film in diagnosing inferior tibiofibular syndesmosis, but the research on CT diagnostic criteria for the diagnose of inferior tibiofibular syndesmosis rotation mismatch is rare. At present, there lacks of systematic research on inferior tibiofibular joint three-dimensional mismatch at home and abroad, especially for the measurement of rotational relationship. Objective: To measure the tibiofibular rotation angle of tibiofibular syndesmosis in normal people with CT imaging. Methods: Twenty-one male and 21 female volunteers were collected for test, and the CT scan was performed to scan the ankle joint. Axial CT measurements included the anterior tibiofibular interval, posterior tibiofibular interval, fibula rotation angle, tibiofibular articular surface tangent angle and tibia Philippians articular surface tangent angle. Two researchers accomplished the measurement at three different occasions independently, and evaluated each CT data. RESULTS AND CONCOUSION: A total of 42 ankles enrolled in the study of data analysis. The tibial surface shape of the tibiofibular syndesmosis was described as deep curved, shallow arc, shallow sloping and flat-shaped. The deep curved symmetrical sydesmosis was the most common type. The shape of fibula was divided into triangular, circular, elliptical, and the most common shape was triangle. Each measurement data was in 95% confidence interval: the anterior tibiofibular interval was 2.10-2.25 mm, the posterior tibiofibular interval was 4.14-4.29 mm, fibula rotation angle was 103.97°-106.30°, tibiofibular articular surface tangent angle was 21.88°-26.64°, tibia Philippians articular surface tangent angle was 33.03°-36.63°. The fibula rotation angle had the smallest variation coefficient with relative small fluctuations and was more representative. The fibular rotational angle was the most stable parameter when comparing with the rest parameters. These data in the study provided the data base with regarding to the precise reduction of the tibiofibular syndesmosis.


Yu X.,Nanchang University | Yang Y.,Xinyu Peoples Hospital | Zhang B.,Nanchang University | Liu H.,Nanchang University | And 2 more authors.
Oncology Letters | Year: 2016

Pleomorphic rhabdomyosarcoma (PRMS) is a rare type of soft tissue tumor accounting for <2% of all adult sarcomas. The present study describes a case of a 28-year-old male patient with primary PRMS of the right thigh. The patient was initially diagnosed with a schwannoma and underwent conservative therapy at a local hospital. At the 6-month follow-up, the patient reported a marked increase in the size of the mass. Finally, the patient underwent fine-needle aspiration and total tumor resection. The tumor measured 11x9x5 cm³ in size and was located in the vastus intermedius muscle. According to histological and immunohistochemical findings, a diagnosis of PRMS was confirmed by an expert pathology consultant. Postoperative follow-up at 3 months revealed no evidence of recurrent disease or residual side effects from therapy. However, it is imperative that such cases are closely monitored following surgery, in order to evaluate the long-term efficacy of the procedure, since misdiagnosis may increase the risk of recurrence and metastasis. The present case is note- worthy due to the misdiagnosis of PRMS, the large size of the mass and the young age of the patient. © 2016, Spandidos Publications. All rights reserved.


Yi S.-H.,Xinyu Peoples Hospital | Zhang Y.,Jiangsu Taizhou Peoples Hospital | Tang D.,Changzheng Hospital | Zhu L.,Changzheng Hospital
Biotechnology Letters | Year: 2015

Objectives: Hepatic stellate cells (HSCs), the principal producers of extracellular matrix proteins, play a major role in the development of liver fibrosis which is accompanied with elevated sinusoidal pressure and portal hypertension. We have isolated primary rat HSCs and investigated the effect of mechanical pressure and tensile strain on retinol metabolism in the cells. Results: Mechanical force and tensile strain significantly increased the expression of α-smooth muscle actin (α-SMA) and collagen I, and notably inhibited the expression of cellular retinol-binding protein I (CRBP-I), lecithin-retinol acyltransferase (LRAT), retinyl ester hydrolase (REH), retinoic acid receptor-β (RAR-β) and retinoid X receptor-α (RXR-α). Such effects were partially reversed by the retinoid X receptor antagonist, HX531, and the retinoic acid receptor antagonist, LE135. Conclusion: Mechanical force and tensile strain significantly activate HSCs by regulating the retinoid metabolic pathway. Activation of HSCs can therefore be manipulated through mechanical force and tensile strain in vitro. © 2015, Springer Science+Business Media Dordrecht.


Hu X.,Soochow University of China | Hu X.,Xinyu Peoples Hospital | Yang J.,Soochow University of China | Wang Y.,Soochow University of China | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: Cell-based angiogenesis is a promising treatment for ischemic diseases; however, survival of implanted cells is impaired by the ischemic microenvironment. In this study, mesenchymal stem cells (MSCs) for cell transplantation were preconditioned with trimetazidine (TMZ). We hypothesized that TMZ enhances the survival rate of MSCs under hypoxic stimuli through up-regulation of HIF1-α. Methods and results: Bone marrow-derived rat mesenchymal stem cells were preconditioned with 10 μM TMZ for 6 h. TMZ preconditioning of MSCs remarkably increased cell viability and the expression of HIF1-α and Bcl-2, when cells were under hypoxia/reoxygenation (H/R) stimuli. But the protective effects of TMZ were abolished after knocking down of HIF-1α. Three days after implantation of the cells into the peri-ischemic zone of rat myocardial ischemia-reperfusion (I/R) injury model, survival of the TMZ-preconditioned MSCs was high. Furthermore, capillary density and cardiac function were significantly better in the rats implanted with TMZ-preconditioned MSCs 28 days after cell injection. Conclusions: TMZ preconditioning increased the survival rate of MSCs, through up-regulation of HIF1-α, thus contributing to neovascularization and improved cardiac function of rats subjected to myocardial I/R injury. © 2015, E-Century Publishing Corporation. All rights reserved.


Fu M.-G.,Nanjing Medical University | Fu M.-G.,Xinyu Peoples Hospital | Li S.,Nanjing Medical University | Yu T.-T.,Nanjing Medical University | And 11 more authors.
FEBS Letters | Year: 2013

MicroRNAs (miRNA) have played an important role in carcinogenesis. In this study, Agilent miRNA microarray was used to identify differentially expressed miRNAs in esophageal squamous cell carcinoma (ESCC) tissues and miR-195 was downregulated in ESCC compared with normal esophageal tissues. Moreover, Cdc42 was confirmed as target gene of miR-195. Ectopic expression of miR-195 in ESCC cells significantly downregulated Cdc42 by directly binding its 3′ untranslated regions, and induced G1 cell cycle arrest, leading to a significant decrease in cell growth, migration, and invasion in vitro. Therefore, our findings demonstrated that miR-195 may act as a tumor suppressor in ESCC by targeting Cdc42. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


Pan P.-S.,Xinyu Peoples Hospital | Zou Y.-B.,Xinyu Peoples Hospital | Wan L.-L.,Xinyu Peoples Hospital | Mei H.,Xinyu Peoples Hospital | And 2 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2013

OBJECTIVE: To evaluae the therapeutic effect and prognostic factors of hypofractionated three-dimensional conformal radiotherapy (3DCRT) combined with transcathether arterial chemoembdization (TACE). METHODS: Fifty patients with primary liver cancer (PLC) who were not suitable for surgery conducted hypofractionated 3DCRT, division dose 3-6 Gy, biological effectiveness dose 52-84 Gy, Median dose 61 Gy. The patients acceped TACE treatment 1-3 times before radiotherapy. RESULTS: In the fifty patients with hepatic cancer complete remission (CR) was 16% (8/50), partial remission (PR) was 62% (31/50), no change (NC) was 14% (7/50), advance was 8% (4/50), and total effective rate (CR+PR) was 78%. And 1, 2, 3 year survival rate was 74% (37/50), 58%(29/50) and 34% (17/50) respectively. Median survival time was 22.5 months. Multivariate analysis demonstrated that the amount of tumor, gross tumor volume, Child-pugh scale were the major prognostic factors which influenced survival rate. CONCLUSION: Hypofractionated 3DCRT associaed with TACE is a effective method in the treatment of moderate and advanced liver carcinoma.


Zhang X.-Y.,Xinyu Peoples Hospital | Ai M.-F.,Xinyu Peoples Hospital | Hu B.,Xinyu Peoples Hospital
World Chinese Journal of Digestology | Year: 2015

AIM: To perform a systematic review of the clinical efficacy and safety of capecitabine combined with radiotherapy in advanced rectal cancer. METHODS: MEDLINE, the China Biological Medicine Disc (CBM), the China National Knowledge Infrastructure (CNKI) and Wanfang databases were searched to retrieve studies evaluating the clinical efficacy and safety of capecitabine combined with radiotherapy in advanced rectal cancer. In accordance with evidence-based medicine (Cochrane) systematic overview methods, the quality of the included studies was assessed and valid data were extracted. Meta-analysis was performed using RevMan5.3 software. RESULTS: Thirty-two trials involving 1876 patients were analyzed in this meta-analysis. The results of Meta-analysis showed that the experimental group had significantly higher overall response rate, radical resection rate, anus-saving rate, one- and two-year survival rates, as compared with the control group (P < 0.01). The anastomotic leakage rate and local recurrence (LR) rate after treatment in the experimental group were significantly lower than those in the control group (P < 0.01). Furthermore, the rates of adverse reactions were also higher in the experimental group than those in the control group. No difference in the remission rate of pain was found between the experimental and control groups (P > 0.01). CONCLUSION: In Chinese patients with advanced rectal cancer, short-term efficacy and longterm survival rates associated with capecitabine combined with radiotherapy are significantly better than those with other therapies, but the combination therapy causes more adverse reactions. The remission rate of pain does not significantly differ in the two groups. © 2015 Baishideng Publishing Group Inc. All rights reserved.


Wen X.,Xinyu Peoples Hospital | Liu H.,Xinyu Peoples Hospital | Yu K.,Xinyu Peoples Hospital | Liu Y.,Xinyu Peoples Hospital
Tumor Biology | Year: 2014

A number of studies investigated the impact of matrix metalloproteinase 2 (MMP2) expression on the survival of patients with osteosarcoma, but no consistent results were reported. To derive a more precise estimate of the prognostic role of MMP2 expression in patients with osteosarcoma, we systematically reviewed the published studies and carried out a meta-analysis. Cohort studies assessing the prognostic role ofMMP2 expression in patients with osteosarcoma were included. Pooled risk ratio (RR) with 95 % confidence intervals (95%CI) was used to assess the prognostic role of MMP2 expression. Five cohort studies were eligible in the meta-analysis. Overall, high MMP2 expression was associated with increased risk of mortality in patients with osteosarcoma during the follow-up (fixed effects RR=2.14, 95%CI 1.66-2.75, P <0.001). Sensitivity analysis suggested that the pooled RR was stable and omitting a single study did not change the significance of the pooled RR. There was some possibility of publication bias risk in the meta-analysis. In conclusion, the meta-analysis suggests that osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression.


PubMed | Xinyu Peoples Hospital
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2014

A number of studies investigated the impact of matrix metalloproteinase 2 (MMP2) expression on the survival of patients with osteosarcoma, but no consistent results were reported. To derive a more precise estimate of the prognostic role of MMP2 expression in patients with osteosarcoma, we systematically reviewed the published studies and carried out a meta-analysis. Cohort studies assessing the prognostic role of MMP2 expression in patients with osteosarcoma were included. Pooled risk ratio (RR) with 95% confidence intervals (95%CI) was used to assess the prognostic role of MMP2 expression. Five cohort studies were eligible in the meta-analysis. Overall, high MMP2 expression was associated with increased risk of mortality in patients with osteosarcoma during the follow-up (fixed effects RR=2.14, 95%CI 1.66-2.75, P<0.001). Sensitivity analysis suggested that the pooled RR was stable and omitting a single study did not change the significance of the pooled RR. There was some possibility of publication bias risk in the meta-analysis. In conclusion, the meta-analysis suggests that osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression.


PubMed | XinYu Peoples Hospital
Type: Journal Article | Journal: Biotechnology letters | Year: 2015

Hepatic stellate cells (HSCs), the principal producers of extracellular matrix proteins, play a major role in the development of liver fibrosis which is accompanied with elevated sinusoidal pressure and portal hypertension. We have isolated primary rat HSCs and investigated the effect of mechanical pressure and tensile strain on retinol metabolism in the cells.Mechanical force and tensile strain significantly increased the expression of -smooth muscle actin (-SMA) and collagen I, and notably inhibited the expression of cellular retinol-binding protein I (CRBP-I), lecithin-retinol acyltransferase (LRAT), retinyl ester hydrolase (REH), retinoic acid receptor- (RAR-) and retinoid X receptor- (RXR-). Such effects were partially reversed by the retinoid X receptor antagonist, HX531, and the retinoic acid receptor antagonist, LE135.Mechanical force and tensile strain significantly activate HSCs by regulating the retinoid metabolic pathway. Activation of HSCs can therefore be manipulated through mechanical force and tensile strain in vitro.

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