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Li X.,Xinjiang Medical University | Babayi A.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Sang W.,Xinjiang Medical University | Abulajiang G.,Xinjiang Medical University | And 3 more authors.
Clinical Laboratory | Year: 2014

Background: Extranodal nasal-type NK/T-cell lymphoma (ENKTCL) is a common and geographic predominant disease in China. We observed the clinical and pathologic features of this tumor type and its relationship to Epstein-Barr virus (EBV), and focused on the epidermology and prevalence of ENKTCL in Xinjiang, in order to improve the diagnostic and differential diagnosis ability. Methods: 103 cases with nasal-type NK/T-cell lymphoma were recruited and assessed. All cases were submitted for histological assessment, immunophenotyping, in situ hybridization detection of EBV-encoded RNA (EBER), and clinical information analysis. Results: Male patients, aged between 40 and 50 years, were predominantly of Han ethnicity outnumbering those of Uyghur ethnicity. 80 cases of ENKTCL involved the nasal cavity or other areas of the upper respirodigestive tract whereas the remaining ones involved other extranodal sites. All cases exhibited similar histological changes: necrosis and inflammatory infiltration were frequently present. Cytologic atypical as well as angiocentric and angiodestructive growth patterns of the tumor cells were consistently noted, although the sizes and contours of the tumor cells varied considerably. All cases expressed one or several T-cell markers and at least one cytotoxic molecule. 86 cases (84%) expressed CD56, and 97 cases submitted for EBER detection showed positive results. ENKTCL affects predominantly middle-aged Han Chinese in the Xinjiang region, with a predilection to involvement of the nasal cavity and a strong association with a high EBV load. Conclusions: Early and correct identification of the disease in daily practice depends on the combination of morphologic evaluation, immunophenotypic assessment, and EBER detection. Source


Tao W.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Gao F.,Xinjiang Uyghur Autonomous Region Peoples Hospital
Chinese Journal of Gastroenterology | Year: 2014

Background: It has been widely recognized that the mortality of colorectal cancer could be reduced by effective intervention strategies. Aims: To investigate the prevalence of colorectal diseases in people undergoing health examination in Xinjiang Uyghur Autonomous Region and the necessity of colonoscopic screening in asymptomatic population. Methods: A retrospective analysis was carried out in asymptomatic healthy subjects who voluntarily accepted colonoscopy at Xinjiang Uyghur Autonomous Region People's Hospital from July 2009 to June 2013. Results: A total of 1970 cases were recruited in this study. The overall detection rate of colorectal lesions was 39.4%, of which 376 cases (19.1%) had colorectal polyps, 10 (0.5%) had colorectal cancer and 38 (1.9%) had melanosis coli. In 560 colorectal polyps detected, tubular adenoma located at left hemicolon was more frequent than other types of polyps. The prevalence of colorectal polyps was higher in males than in females (24.6% vs. 11.2%, P<0.001) and increased with the advancing of age (≥50 years old vs. <50 years old: 25.9% vs. 14.3%, P<0.05). More polyps were detected in Han nationality than in Uyghur and Kazak (22.6% vs. 10.9% and 10.9%, P<0.05). Conclusions: The prevalence of colorectal polyps is fairly high in asymptomatic healthy subjects. Males and individuals with advancing age (≥50 years old) and Han nationality are more prone to have colorectal polyps. For asymptomatic subjects above 50 years old, screening for colorectal diseases by colonoscopy is worthwhile. COPYRIGHT © 2014 by the Editorial Office of Chinese Journal of Gastroenterology. Source


Han L.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Han L.,Xinjiang Medical University | Husaiyin S.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Wang L.,Xinjiang Uyghur Autonomous Region Peoples Hospital | And 3 more authors.
Genetics and Molecular Research | Year: 2015

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were genotyped using polymerase chain reaction-sequence-based typing (PCR-SBT) for HLA-DQB1. Two hundred and ninety-six alleles were identified among the 160 cases. One hundred and thirty-six alleles were heterozygous and 24 were homozygous. Using frequency calculations and statistical analysis, we found that HLA-DQB1*0325 (OR: 10.60, 1.341-83.81) and HLA-DQB1*0332 (OR: 12.59, 2.909-54.526) were more frequently identified in the cervical cancer group compared with the cervicitis group (P < 0.05). However, HLA-DQB1*0317 (OR: 0.49, 0.304-0.798) and HLA-DQB1*040302 (OR: 0.40, 0.243-0.658) were present less frequently in the cervical cancer group (P < 0.05). The frequency of the HLA-DQB1 genotype in Uyghur was different from that reported previously in other areas. HLA-DQB1*0325 and HLA-DQB1*0332 probably act as cervical cancer susceptibility genes in Uyghur women from Xinjiang. In contrast, HLA-HLA-DQB1 allele polymorphisms in cervical cancer © FUNPEC-RP. Source


Sui S.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Niyazi M.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Wang L.,Xinjiang Uyghur Autonomous Region Peoples Hospital | Jiao Z.,Xinjiang Uyghur Autonomous Region Peoples Hospital | And 2 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2015

OBJECTIVE: To statistics Uyghur women's cervical biopsy results who are aged over 30 with different types of HPV infection and negative cervical cytology test, and to analyze the risks of different types of HPV infection to high-grade cervical lesions to provide a theoretical basis for the standardized management for women who are HPV-positive without cervical lesions. METHODS: The data of 199 patients who were aged over 30 with different types of HPV infection was collected and cervical cytology test were negative for cervical screening between 2012.01.01 and 2014.02.28 in out-patient Department of Xinjiang Uyghur Autonomous Region People's Hospital, with colposcopy and cervical multi-point histopathological examination. The highly cervical lesions diagnosis rate with various types of HPV was analyzed, and logistic regression was used to analyze the risk of highly cervical lesions with different types of HPV infection. RESULTS: There were 199 patients in total who suffered high risk HPV infection but cytology test were negative. The most common HPV types were HPV 16, 58, 52, 53, 31.High-grade cervical lesions were confirmed in 18.59%(37/199). Among high risk HPV type, women with HPV 16 positive had been confirmed to be highly cervical lesions, diagnosis rate was 38.48%(20/58), women with HPV58 positive had been confirmed to be highly cervical lesions, diagnosis rate was 30.23%(13/43), women with HPV52 positive had been confirmed to be highly cervical lesions, diagnosis rate was 5.90%(2/34), women with HPV53 positive had been confirmed to be highly cervical lesions, diagnosis rate was 3.70%, women with HPV18 positive had been confirmed to be highly cervical lesions, diagnosis rate was11.11%(1/9). HPV16 positive increased the risk of highly cervical lesions compared to those HPV16 negative ones, the odd ratio was 3.839(95%CI: 1.829-8.060), P=0.001.HPV58 increased the risk of highly cervical lesions compared to those HPV58 negativeones, the odd ratio was 2.365 (95%CI: 1.476-7.669), P=0.004.CONCLUSION: Clinicians have to pay more attention to women aged over 30 years whose cervical cytology test is negative but high risk HPV positive, and immediate colposcopy is necessary, especially with those HPV 16 and 58 infection ones. ©, 2015, The Editorial Board of Chinese Journal of Cancer Prevention and Treatment. All right reserved. Source

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