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Ding C.,Xinjiang University | Ding C.,Xinjiang Product Quality Supervision and Inspection Research Institute | Xu S.,Xinjiang University | Lin J.,Xinjiang University | And 6 more authors.
Journal of Polymer Research | Year: 2012

The layer-by-layer (LbL) assembled multilayer films are widely used in controlled drug delivery. Here, hydrogen-bonded LbL multilayer films were assembled through alternating deposition of poly(vinylpyrrolidone) (PVPON) and poly(acrylic acid) (PAA) on glass slides. Methylene blue (MB) was used as a model drug to investigate the loading and release ability of the prepared multilayer film. The results showed that the loading rate of MB was greatly influenced by pH value of the dye solution, and the release rate was controlled both by ionic strength and pH value of immersing solution. The result also indicated that the loading and release of MB were reversible and can be repeated many times. It suggested that the PVPON/PAA multilayer film had potential applications in drug delivery and controlled release. © 2012 Springer Science+Business Media B.V. Source


Li S.,Xinjiang University | Yin C.,Xinjiang Product Quality Supervision and Inspection Research Institute | Ren S.,Xinjiang Product Quality Supervision and Inspection Research Institute | Yang T.,Xinjiang Product Quality Supervision and Inspection Research Institute | And 2 more authors.
Journal of Separation Science | Year: 2015

A simple strategy was developed for the preparation of multi-hollow magnetic molecularly imprinted polymers by incorporating 3-indolebutyric acid and ferroferric oxide nanoparticles simultaneously into a poly(styrene-co-methacrylic acid) copolymer matrix. The as prepared absorbents were characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy and mercury porosimetry. The adsorption isotherms of indolebutyric acid revealed that there are two types of affinity binding sites in the absorbents. The apparent maximum binding capacity and dissociation constant were 17.88 mg/g and 158.7 μg/mL for high-affinity binding sites and 9.310 mg/g and 35.04 μg/mL for low-affinity binding sites, respectively. The results testified that multi-hollow magnetic molecularly imprinted polymers possessed excellent recognition capacity and fast kinetic binding behavior to the objective molecules due to the high specific surface area as large as 511.3 m2/g. Recoveries of 75.5-86.8% were obtained for the indolebutyric acid spiked at three concentration levels in blank and pear samples. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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