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Xinyi, China

Xinjiang Medical University , formerly the Xinjiang Medical College, is a medical university in Ürümqi, the capital of the Xinjiang Uyghur Autonomous Region of the People's Republic of China. It was ratified by the National Ministry of Education in 1998 and entitled by Jiang Zemin.The curriculum places a particular emphasis on medicine, management and linguistics, with the university facilitating 25 specialties for undergraduate students and 17 specialties for academic education. Over 50,000 students have been educated at XMU and in 2010, 13,100 students were enrolled at the university, with 5,405 people employed in teaching positions. XMU is situated at the base of Carp Hill in Northeast Ürümqi and consists of a campus size that is over 3 million square feet. Wikipedia.

Objective: To evaluate the efficacy of the intensity modulated radiotherapy in early stage cervical cancer with vaginal stump recurrence after surgery. Methods: A retrospective concurrent comparative study included 60 patients with vaginal recurrence after surgery in early stage cervical cancer. 30 cases of the experimental group were treated with intensity-modulated radiotherapy (IMRT), and 30 cases of the control group were treated with conventional radiotherapy. The efficacy and complications between two groups were compared after 3 treatment cycles. Results: Of 30 patients in experimental group, 22 patients achieved complete remission, 7 had partial and 1 progressed. But in the control group, 14 had complete remission, 5 reached partial remission, 7 were stable and 4 progressed. The effective rates were 96.67% (29/30) and 63.33% (19/30), respectively, in the experimental and control group, which showed statistical significance (P = 0.009). In the experimental group, there were 1 case with grade 1 radiation cystitis and 1 case with grade 1 radiation proctitis. In the control group, there were 3 cases of vaginal-rectal fistula, 1 case of grade 3 radiation proctitis, 2 cases of grade 2 radiation cystitis and 2 cases of grade 1 radiation proctitis. Conclusions: IMRT for treating vaginal recurrence of early cervical cancer achieves satisfactory short-term effect. In comparison with conventional radiotherapy, IMRT has higher efficacy but less side effects. Source

Zhou X.,Xinjiang Medical University
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | Year: 2013

Complete lead extraction of cardiac implantable electronic devices (CIED) for device-related infections remains a complex procedure for chronically implantated leads. We present data from a single-centre registry of consecutive patients with extractions over 10 years. Patients were identified from the centre's electronic database with CIED-related infections who underwent lead extraction using either the standard technique and equipment or a modified innovative transvenous lead technique extraction using an ablation catheter. Of 151 patients with CIED-related infections, not responding to simple manual traction to effect lead extraction, average age 65 ± 8 years (range 45-82), 64% being male, 75 underwent standard (S) extraction, and 76 underwent modified (M) extraction. Procedural, lead extraction, and fluoroscopy exposure times with S and M methods, respectively, were 65 ± 14 vs. 52 ± 6 min (P < 0.01), 56 ± 12 vs. 36 ± 8 min (P < 0.001), and 48 ± 12 vs. 31 ± 7 min (P < 0.001). Retrieval rates were numerically lower with the standard technique at 92 vs. 96% but did not achieve significance, with respective complication rates of 6.7 and 5.3%. In our single-centre study, a modified extraction technique to retrieve leads for infections of CIEDs using a steerable ablation catheter has improved procedural parameters over the standard technique, without compromising clinical lead extraction success rates. This may be a promising approach for a future, prospective trial. Source

Objective: Knowing the BRCA gene mutational condition of high risk triple negative breast cancer (TNBC) in Xinjiang Uygur Autonomous and acquiring the differences of clinical and pathologic characteristics between person with BRCA gene mutation and person without it by means of BRCA gene mutation testing for 30 cases of TNBC in Xinjiang Uygur Autonomous. Methods: The objects of this study were 30 cases of high risk TNBC from Xinjiang. All the coded sequences of BRCA1/2 gene were amplified by means of extracting genomic DNA from peripheral venous blood. BRCA1/2 gene mutation analysis were prescreened through DHPLC. Then, the result was verified by DNA sequencing. The clinical and pathologic characteristics between person with BRCA gene mutation and person without it of 30 high risk TNBC cases were contrastively analysed. Results: In all the 30 cases of BRCA gene mutation testing for TNBC in Xinjiang Uygur Autonomous, there were 5 cases of pathogenic mutations of BRCA gene (5/30, 16.7%); 4 cases of BRCA 1 mutation (4/30, 13.3%); 1 case of BRCA 2 mutation (1/30, 3.3%); and there was no mutation to be found in 25 cases of BRCA gene of TNBC (25/30, 83.3%). As compared with person without gene mutation, who with it had the characteristics of earlier of TNM, the difference was statistically significant (P = 0.040). Conclusion: Since the rate of BRCA1 gene mutation of high risk TNBC is higher. It is suggested that the BRCA gene of every patients with high risk TNBC should be tested. Comparing with person with BRCA gene mutation and person without it, there might have differences on clinical pathological characteristics features. Therefor, individualized treatment should be taken into consideration. Source

Xu X.C.,Xinjiang Medical University
European journal of histochemistry : EJH | Year: 2013

The receptor for advanced glycation endproducts (RAGE) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of RAGE in gastric cancer is still elusive. In this study, we investigated the expression and molecular mechanisms of RAGE in gastric cancer cells. Forty cases of gastric cancer and corresponding adjacent non-cancerous tissues (ANCT) were collected, and the expression of RAGE was assessed using immunohistochemistry (IHC) in biopsy samples. Furthermore, RAGE signaling was blocked by constructed recombinant small hairpin RNA lentiviral vector (Lv-shRAGE) used to transfect into human gastric cancer SGC-7901 cells. The expression of AKT, proliferating cell nuclear antigen (PCNA) and matrix metallopeptidase-2 (MMP-2) was detected by Real-time PCR and Western blot assays. Cell proliferative activities and invasive capability were respectively determined by MTT and Transwell assays. Cell apoptosis and cycle distribution were analyzed by flow cytometry. As a consequence, RAGE was found highly expressed in cancer tissues compared with the ANCT (70.0% vs 45.0%, P=0.039), and correlated with lymph node metastases (P=0.026). Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest. Altogether, upregulation of RAGE expression is associated with lymph node metastases of gastric cancer, and blockade of RAGE signaling suppresses growth and invasion of gastric cancer cells through AKT pathway, suggesting that RAGE may represent a potential therapeutic target for this aggressive malignancy. Source

BACKGROUND: The prevalence of early childhood caries (ECC) varies with geographical region and population. The Uygur people, one of 55 officially recognized ethnic minorities in China, have a population of 10,069,346. We performed a preschool-based cross-sectional study of 670 Uygur children from the southern region of Xinjiang, China, to investigate the prevalence and severity of ECC and to identify factors related to the dental health condition of this population.METHODS: The study population of children ranging in age from 3 to 5 years was invited using a three-stage stratified sampling in Kashgar, the westernmost city in China. The "dmft" index was used to assess dental caries. The diagnosis of ECC or severe ECC was based on the oral health diagnostic criteria defined by the American Academy of Pediatric Dentistry. A questionnaire was completed by the children's caregivers. The survey included questions concerning the children's sociodemographic background; feeding and eating habits, particularly frequency of sweet beverage and food consumption; dental hygiene-related behaviors; the general oral health knowledge of caregivers; and the dental healthcare experience of caregivers and their children.RESULTS: A total of 670 Uygur children underwent complete dental caries examination. Most of the children (74.2%) had ECC, with a mean dmft ± SD of 3.95 ± 3.84. The prevalence of severe ECC was 40.1% (N =269), with a mean dmft of 7.72 ± 3.14. More than 99% of caries were untreated. Statistically significant correlations were found between higher ECC prevalence and increased age and lower socioeconomic background, while greater dental health knowledge of the caregiver and positive oral hygiene behaviors were found to be protective. Our findings confirm the multi-factorial etiology of ECC.CONCLUSIONS: The prevalence of ECC among preschool-aged Uygur children in Kashgar was high, particularly among those from lower socioeconomic backgrounds. Caries prevalence was associated with oral hygiene behaviors of children and the general oral health knowledge of caregivers. These factors could be modified through public health strategies, including effective publicity concerning general dental health and practical health advice. Source

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