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Wang Y.,Xinjiang Medical University | Xu P.-P.,Xinjiang Medical University | Li X.-X.,Xinjiang Medical University | Nie K.,Xinjiang Medical University | And 3 more authors.
Journal of Pharmaceutical Analysis | Year: 2012

The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets. © 2012 Xian Jiaotong University. Source


Li X.-X.,Xinjiang Medical University | Wang Y.,Xinjiang Medical University | Xu P.-P.,Xinjiang Medical University | Zhang Q.-Z.,Xinjiang FOCS Bio Technology Co. | And 5 more authors.
Journal of Pharmaceutical Analysis | Year: 2013

The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)<1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of λmax (218 nm) was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature (37° C) with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets. © 2013 Xi'an Jiaotong University. Source

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