Xingtai Medical College
Xingtai Medical College
Zheng L.,Xingtai Medical College
Biomedical Research (India) | Year: 2017
Background: The Early Stage of Obesity by Fatigue (ESOF) is a serious sub-health issue due to the social burden and a leading cause of other diseases even death. Accordingly, a broad range of dietary supplements have been researched and applied in an effort to treat ESOF. However, only a small number of dietary supplements have been specifically applied for gene diagnosis and the targeted gene therapy for early treatment of obesity by fatigue. Materials and methods: In order to search the target genes for the examination in this research, GSE 038921 was downloaded from the public database, Gene Expression Omnibus, including all three samples of test and control groups. Analysis was carried out using R software packages, protein-protein interaction network, Kyoto Encyclopaedia of Genes and Genomes pathway and Gene ontology enrichment. It yielded a total of six key genes caused by limited sleep. The result was tested and verified by other data: GSE 65557 and GSE 34959. Results: Finally, one gene and one key pathway were identified: Plg; complement and coagulation cascades. Conclusions: This study suggested target gene and biological marker for treatments of ESOF by dietary supplements, providing a new perspective on the pathological process of the early phrase of ESOF. © 2017, Scientific Publishers of India. All rights reserved.
Zeng R.,Hebei Medical University |
Li C.,Hebei Medical University |
Li N.,Hebei Medical University |
Li N.,Xingtai Medical College |
And 2 more authors.
Cytokine | Year: 2011
Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in infants and young children worldwide. The mechanism is largely unknown. RSV stimulates airway epithelial cells and resident leukocytes to release cytokines. Cytokines and chemokines involved in host response to RSV infection are thought to play a central role in the pathogenesis. In addition, RSV infection early in life has been associated with the development of asthma in later childhood. It is likely that the persistence of cytokines and chemokines in fully recovered patients with RSV in the long term can provide a substratum for the development of subsequent asthma. This review describes the genetic factors in cytokines and chemokines associated with severity of RSV disease, cytokines and chemokines synthesis in RSV infection, and the role of these innate immune components in RSV-associated asthma. © 2010 Elsevier Ltd.
Yan H.,Hebei University |
Wang H.,Hebei University |
Wang H.,Xingtai Medical College
Journal of Chromatography A | Year: 2013
Dispersive liquid-liquid microextraction (DLLME) is a modern sample pretreatment technique that is regarded as consilient with the current trends of modern analytical chemistry. DLLME is simple, inexpensive, environmentally friendly, and could offer high enrichment factors from a wide gap between acceptor and donor phases. As a consequence, DLLME has attracted considerable attention from researchers and, based on the numerous publications concerning DLLME, has been generally accepted in separation science since the technique's invention in 2006. However, several innate weaknesses of DLLME, which restrict the technique's use in certain fields, have led to various attempts or suggestions to improve this technique. The present review focuses on the recent advances made in DLLME; the selected papers that are discussed in this work represent modifications that fall into three main categories (exploration of new extraction solvents, disperser solvents and combination with other techniques). The recent applications of DLLME in environmental, food and biological samples are also summarised, covering almost all of the publications related to the technology from the beginning. In addition, the feasibility of future trends of DLLME is discussed. © 2013 Elsevier B.V.
Wang H.,Xingtai Medical College |
Wang R.,Shijiazhuang Maternal and Child Health Hospital |
Han Y.,Hebei University
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | Year: 2014
An inorganic-organic co-functional monomer, methacrylic acid-vinyltriethoxysilan (MAA-VTES) was designed for the synthesis of molecularly imprinted microspheres (MIMs). By virtue of the aqueous suspension polymerization and dummy template (pazufloxacin), the obtained MAA-VTES based MIMs exhibited good recognition and selectivity to fluoroquinolones (FQs), and were successfully applied as selective sorbents of a miniaturized home-made solid phase extraction device for the determination of ofloxacin (OFL), lomefloxacin (LOM) and ciprofloxacin (CIP) in milk samples. Under the optimum conditions of the miniaturized molecularly imprinted solid phase extraction (mini-MISPE) coupled with liquid chromatography-ultraviolet detector (LC-UV), good linearities were obtained for three FQs in a range of 0.2-20.0μgmL-1 and the average recoveries at three spiked levels were ranged from 87.2% to 106.1% with the relative standard deviation (RSD) less than 5.4%. The presented co-functional monomer based mini-MISPE-LC-UV protocol introduced the rigidity and flexibility of inorganic silicon materials, exhibited excellent extraction performance towards targets, and could be potentially applied to the determination of FQs in milk samples. © 2013 Elsevier B.V.
Dou Y.,XingTai Medical College
Advanced Materials Research | Year: 2014
With computer simulation approach and theoretical mechanics analysis approach, according to two kinds of the loop plays, the author studied and compared the state change laws of loop after colliding. The two kinds of results received in analysis are identical. The speed of high-speed loop slows down to some extent, but rotate is strengthened, and the speed of high-spin loop drive is accelerated, but rotate is weaken. The paper indicates that computer simulation technology can be applied to dynamics study and state measurement of table tennis, and it also has certain guidable meaning for practicing. © (2014) Trans Tech Publications, Switzerland.
Zheng L.,Xingtai Medical College
Advanced Materials Research | Year: 2014
Flavonols is a class of widely distributed in nature polyphenols. Usually, studies have shown that lots of flavonols had certain effect on alcoholism. Studies have show that lots of flavonoids have effect on aminobutyric acid (GABA) which is an important inhibitory neurotransmitter mammalian in central nervous system. Dihydro flavonols, an kind of flavonols may have effect on alcoholism by GABA. Recent studies have shown that dihydro myricetin, an dihydro flavonol, has shown inhibition of GABA receptor gene expression. In like manner, we hypothesize that dihydro flavonols may affect the express of GABA as an effective and specific novel treatment for alcoholism. © (2014) Trans Tech Publications, Switzerland.
Zhang Z.,Xingtai Medical College
Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry | Year: 2016
A new Zn(II) compound, namely [Zn(pam)(bib)]n (1 H2pam = pamoic acid, bib = 1,4-bis(imidazolyl)butane), has been synthesized by the reactions of Zn(II) ions with H2pam and bib ligands under solvothermal conditions. Single-crystal X-ray analysis reveals that compound 1 features a 2D→3D interdigitated supramolecular framework. In addition, the luminescent properties of 1 were also investigated at room temperature. Copyright © Taylor & Francis Group, LLC 2016.
Jin X.,Xingtai Medical College |
Chu L.,Xingtai Medical College
WIT Transactions on Information and Communication Technologies | Year: 2014
The Twenty-first Century is the era of knowledge economy and even an information society. With information technology as the content, service industry has become an important pillar industry in the major economies, with which service science emerges. The application of service science in college physical education teaching, improving the masses' interests in physical exercise, cultivating talents in sports industry, promoting the innovation ability of the sports industry is deeply explored in the paper, which is expected to provide reference for the application of service science in the field of sports science. © 2014 WIT Press.
Jinjie H.,Xingtai Medical College
BioTechnology: An Indian Journal | Year: 2014
To understand the research hotspots of Angiotensin-converting enzyme inhibitors (Pharmacological Action) by PubMed. Methods: With MS Excel, SPSS, Cytoscape software, we took MeSH (Medical Subject Headings) word frequency analysis, clustering analysis, co-word network graph of PubMed papers. Results: It shows that the main research hotspot of ACE-Is (pharmacological action) is Antihypertensive Agents of ACEIs for Hypertension, also it is beneficial to Heart Failure, Myocardial Infarction, Type 2 Diabetes Mellitus, Diabetic Nephropathies, Kidney Diseases, Left Ventricular Dysfunction, and so on. Conclusion: It is helpful and timesaving for researcher or doctor to understand the research hotspots with ACE-Is (Pharmacological Action). © Trade Science Inc.
Shi J.-J.,Xingtai Medical College
International Journal of Ophthalmology | Year: 2010
• AIM: To investigate the operation effects of using different concentration mitomycin C(MMC) intraoperatively on laser epithelium keratectomileusis (LASEK). • METHODS: Totally 261 patients 496 eyes were devided into two groups: group 0.4mg/mL MMC (133 patients, 245 eyes); group 0.2mg/mL MMC (128 patients, 251 eyes). 0.4mg/mL and 0.2mg/mL MMC sulution were intraoperatively applied to the cases respectively. The two kinds of instilled solutions were held up in the eyes for 30, 60, 90 and 110 seconds successively according to the ≤-3.00, -3.25- -6. 00, -6.25 - -9.00, ≥-9. 25 of diopter. The formation of corneal haze, the situation of visual acuity , the change of diopter, corneal endothelium density, the healing of cornea were observed. • RESULTS: All the patients were followed up for 1 year. The clinical data of group 0.4mg/mL MMC and group 0.2mg/mL MMC were respectively as follows; the occurrence rate of haze was 1.2% and 13.2%; the appearance rate of influenced visual acuity was 0.8% and 2.0%; the changes of diopter were -0.52±0.09 and -0.67± 0.11D (1 month), -0.29±0.15 and -0.58±0.21D (6 months), -0.35±0.16 and -0.54±0.18D (12 months); the corneal endothelium density of the two groups prooperation, 1 month, 4 and 12 months after operation respectively was 2994.01±321.89 and 3005.92±382. 54, 2974.89±339.87 and 2996.69±374.19, 3001.02±306.92 and 2988.37±367.33, 3011.18±321.31 and 3000.05±299.84. There was a statistically significant difference (P<0.05) in those index. But there were respectively two cases ( 3 eyes) and two cases (2 eyes) of Filamentary keratitis after taking off lenses in group 0.4mg/mL MMC and group 0.2mg/mL MMC. • CONCLUSION: Using 0.4mg/mL MMC solution intraopera-tively can effectively inhibit haze formation and there for improve the results of LASEK greatly, and it is better than 0.2mg/mL MMC.