Xingjiang Medical University
Xingjiang Medical University
Shi L.-N.,Xingjiang Medical University |
Wang X.-F.,Xingjiang Medical University |
Ma G.-Z.,China Pharmaceutical University |
Kang J.-S.,Xingjiang Medical University |
Gao X.-L.,Xingjiang Medical University
Chinese Pharmacological Bulletin | Year: 2015
Aims To study single dose toxicity of polyphenols effective parts from Punica granatum, to evaluate their safety, and thus to provide a theoretical basis for drug development and clinical use. To observe their protective effect on ethanol-induced gastric ulcer in rats. Methods 50 healthy Kunming mice were randomly divided into five groups and given different doses of polyphenols' effective parts from Punica granatum via intragastric administration. Toxicity and death in each group of mice were observed and recorded after administration for 14 d. The median lethal dose was calculated by Bliss method. 70 rats were randomly divided into normal group, model group (constant volume of normal saline), sanjiuweitai particles (1 850 mg • kg-1) group, colloidal bismuth subcitrate (33 mg • kg-1) group and polyphenols effective parts from Punica granatum low-dose, medium-dose, high-dose(430, 852, 1 704 mg • kg-1) groups. On the 9th day of 10 days' gavage, all except the normal group were fed ethanol (1.5 mL/only) to induce gastric mucosal injury in rats with acute gastric ulcer. Gastric ulcer index, the rate of ulcer inhibition were calculated for each group. The morphological changes of gastric mucosa were observed. The gastric mucosa levels of PGE2, NO, SOD and MDA were determined. Results The LD50 and 95% confidence limit of the polyphenols' effective parts from Punica granatum were 8 520.9 mg • kg-1 and 7 291.2 ∼9 914.4 mg • kg-1, respectively. Pathology showed that the organs receiving dose of 16 000 mg • kg-1 had different degrees of damage. Compared with the model group, the extract from Punica granatum significantly repaired the gastric mucosa, and significantly increased the gastric mucosa levels of NO and reduced MDA content, and improved SOD content and the levels of PGE2. Conclousion The dose of 5 063 mg • kg-1 of polyphenols effective part from Punica granatum showed no death. The dose of 16 000 mg • kg-1 of polyphenols effective parts from Punica granatum could cause varying degrees of damage in heart, liver, lung, kidney or the death of mice. The LD50 and 95% confidence limit of the polyphenols effective parts from Punica granatum were 8 520.9 mg • kg" and 7 291.2-9 914.4 mg • kg".respectively. The extract from Punica granatum plays a protective role against gastric mucosa damage induced by absolute ethanol, and the mechanism may be related to promoting ulcer epithelial cells synthesis, enhancing mucosal regeneration function, regulating NO content and enhancing antioxidant capacity.
Liu F.,Xinjiang Medical University |
Liu F.,Xingjiang Medical University |
Adi D.,Xingjiang Medical University |
Xie X.,Xinjiang Medical University |
And 15 more authors.
PLoS ONE | Year: 2015
Objectives: Little is known about isolated diastolic hypertension (IDH) among different ethnicity groups. We aimed to investigate the prevalence and risk factors for IDH among the major ethnicity population i.e. Han, Uygur and Kazakh in Xinjiang, northwestern part of China. Methods: In total, 14,618 adult participants (7,799 males, 6,819 females) were recruited from the Cardiovascular Risk Survey conducted during 2007 and 2010. Blood pressure, body mass index and standard lipid profile and fasting glucose level from plasma were measured. Results: The overall prevalence of IDH was 10.8% in the Han, 4.5% in the Uygur and 8.7% in the Kazakh populations. When stratified by gender, IDH prevalence was 9.8% in men and 6.8% in women (P<0.001). The prevalence of IDH also varied significantly with age and it was highest in those aged 35-44 yrs old (9.7%) and lowest in those over 75 yrs old (4.1%, P<0.001). Multivariate logistic regression analysis showed that overweight (OR = 1.179, 95%CI: 1.015-1.369) or obesity (OR = 1.202, 95%CI: 1.015-1.424), smoking (OR = 1.362, 95%CI: 1.156-1.604) and high total cholesterol (TC) hyperlipidemia (OR = 1.237, 95%CI: 1.074-1.423) were significantly associated with a higher prevalence of IDH. Identified risk factors for IDH differed among ethnicity groups with male gender, young age (35-44 yrs old), more coffee or tea consumption and high TC hyperlipidemia in the Han; smoking and often coffee or tea consumption in the Uygur and male gender and overweight or obesity in the Kazakh populations. Conclusions: IDH prevalence in the Han population is higher than that in the Uygur and Kazak populations in Xinjiang, northwestern part of China. Male gender, middle age, overweight or obesity, smoking and high TC hyperlipidemia appear to be relevant risk factors of IDH in adults. Different ethnicity background had different sets of risk factors for IDH. © 2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aikemu A.,Xinjiang Medical University |
Aikemu A.,Xingjiang Medical University |
Umar A.,Xinjiang Medical University |
Umar A.,University of Bordeaux 1 |
And 9 more authors.
BMC Complementary and Alternative Medicine | Year: 2012
Background: Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. This study attempts to confirm these effects in vivo and measure effects on the immune system.Methods: Kunming mice transplanted with Sarcoma 180 cells were treated with ASMq (2-8 g/kg/day) by intra-gastric administration compared to model and cyclophosphamide (20 mg/kg/day). After the 14th day post tumour implant, thymus, liver, spleen and tumours were removed, weighed, and processed for histopathological analysis. Blood samples were also taken for haematological and biochemical analyses including TNF-α , IL-1 β and IL-2. Splenic lymphocyte function was measured with MTT; lymphocyte subpopulations were measured by flow cytometry.Results: ASMq treated animals had reduced tumour volume compared to model and increased concentrations of TNF-α, IL-1β and IL-2 compared to untreated and to cyclophosphamide-treated animals. No histopathological alterations were observed. The absence of viable S180 cells and the presence of necrotic cells and granulation tissue were observed in tumour tissue of treated animals. The effect on T lymphocytes was unclear.Conclusions: ASMq confirmed in vivo anti-tumour effects observed in vitro, which may be at least in part mediated by increased immune activity. © 2012 Aikemu et al.; licensee BioMed Central Ltd.
Gao J.,Xingjiang Medical University |
Wang Y.,Xingjiang Medical University |
Yang L.,Xingjiang Medical University |
Yao L.,Xingjiang Medical University
Chinese Journal of Clinical Oncology | Year: 2013
Objective: This study aims to evaluate the consistency between contrast-enhanced ultrasound (CEUS) and enhanced computed tomography (CT) in determining the effect of radiofrequency ablation (RFA) on hepatocellular carcinoma. Methods: RFA procedures guided by either ultrasound or CT were performed on 35 patients with 68 lesions. Enhanced CT and CEUS were regularly conducted after the procedures to evaluate the effect of RFA. The full ablation, residual, and recurrence rates of tumors, as well as the diagnostic accuracies and kappa values of CEUS and enhanced CT, were determined. Results: The full ablation and residual rates of tumors for the 68 lesions diagnosed by CEUS were 84% and 16%, respectively; whereas those for the lesions diagnosed by enhanced CT were 90% and 10%, respectively. No significant difference was found between the obtained rates using the two diagnostic methods (χ2=0.576 3, P=0.447 8). Moreover, the two methods exhibited high consistency (K=0.882 9, Sk=0.120 4). Of the 68 lesions, 13 recurred within 24 months. The recurrence rate evaluated by CEUS was 19% (13/68). No significant difference was found between the detection rates of CEUS (92%, 12/13 lesions) and enhanced CT (100%, 13/13 lesions) in diagnosing recurrent lesions (P>0.05). Enhanced CT could be used as the gold standard for evaluating tumor residual and recurrence rates after RFA. The overall diagnostic accuracy of CEUS reached 92% (63/68 lesions). Conclusion: CEUS and enhanced CT exhibit high accuracy and consistency in evaluating the effect of RFA on hepatocellular carcinoma. CEUS can provide a reliable diagnostic proof for tumor patients after undergoing RFA procedure.
Gu M.,Xinjiang Academy of Agricultural science |
Zhu J.,Xinjiang Academy of Agricultural science |
Song S.,Xinjiang Academy of Agricultural science |
Zhang Z.,Xinjiang Academy of Agricultural science |
And 5 more authors.
Chinese Journal of Environmental Engineering | Year: 2014
An efficient flocculant-producing strain W36-1 was isolated from desert soil in Xinjiang. Based on the Biolog microbial identification system and 16S rRNA gene sequence analysis, strain W36-1 was classified as Erwinia, and may be a novel species. Flocculant ferment of the strain indicated that the ferment belonged to type II. After 48 h culture, the highest yield of flocculation was 6 g/L. Flocculant properties showed that the flocculation had higher temperature stability at 20~100°C. The flocculating activity was higher under acidic conditions, which declined rapidly under alkaline conditions. Some metal cations could promote the flocculating activity, in which Ca2+ was the best, Mg2+ was lower than Ca2+, Al3+ and Fe3+ were the lowest. Furthermore, the flocculant could absorb heavy metals and pigments efficiently, which suggested good application prospective in environmental engineering.
Gao J.-X.,Xingjiang Medical University |
Yu X.-Q.,Xingjiang Medical University |
Yao L.-H.,Xingjiang Medical University
Chinese Journal of Oncology | Year: 2011
Objective: To explore the value of BI-RADS ultrasonic scores of direct and indirect ultrasonographic signs in diagnosis of solid breast lesions. Methods: Reference to the standard BI-RADS score, ultrasonic scores of direct and indirect ultrasonographic signs of 132 solid breast lesions were assigned, and were compared with pathological results. Results: By the direct signs of breast lesions (aspect ratio, shape, border, internal echo, posterior echo, flow grade, sand-like calcification) and indirect signs (changes in local skin thickness, Cooper ligament changes, axillary lymph nodes, depth of reinforcement membrane changes, mass changes in the surrounding burr), the integral from the total scores in benign and malignant breast masses showed a statistically significant difference. The total score of malignant lesions (8.94 ± 2.85) was significantly higher than that of benign tumors (3.09 ± 1.97, P < 0.05). Except skin thickness, all the remaining scores of the signs of benign and malignant breast tumors showed a significant difference between the two groups (P < 0.05). By receiver operating curve (ROC) analysis, the best critical value of the total score of direct signs was ≥4, with a sensitivity and specificity of 0.84 and 0.93, respectively, in distinguishing breast carcinoma from benign lesions. The best critical value of the total score of indirect signs was ≥ 1, with a sensitivity and specificity of 0.82 and 0.74, respectively. The critical value of the combination of the direct and indirect signs was ≥5 in differential diagnosis of malignant and benign lesions with a sensitivity and specificity value of 0.88 and 0.90, respectively. Conclusion: The assignment score to the ultrasound characteristics of the direct and indirect signs of solid breast lesions can make a more objective diagnosis, yet it is a simple, effective, comprehensive and semi-quantitative analysis method.
Wang X.,Xingjiang Medical University |
Gu L.H.,Xingjiang Medical University |
Dong Z.,Xingjiang Medical University |
Lu H.,Xingjiang Medical University |
Ni D.,Xingjiang Medical University
Chinese Journal of Clinical Oncology | Year: 2010
Objective: To explore the clinical value of 99mTc-sulfur colloid (Sc) preoperative lymphoscintigraphy in sentinel lymph node biopsy (SLNB) in breast cancer patients. Methods: Participants included 70 patients with breast cancer who underwent sentinel lymph node (SLN) detection with preoperative lymphoscintigraphy between July 2009 and January 2010. A dose of 37MBq 99mTc-SC was hypodermically injected around the tumor at 3, 6 and 12 o'clock positions on the breast. Lymphoscintigraphic images were taken at 15 min, 30 min, 1h, and 2h after hypodermic injection. Intraoperative detection of "hot spot" lymph nodes was performed with a handheld gamma probe (γ-detection). Data from the breast cancer patients who received consecutive preoperative lymphoscintigraphy before SLNB in our database were analyzed. Results: Sentinel lymph nodes (SLN) were well imaged by lymphoscintigraphy in 60 (85.71%) patients, and SLN were found in the extra-maxillary space in 5 patients (7.15%). The success rate of SLNB in lymphoscintigraphy was not associated with histopathologic type or the stage and location of the primary tumor (P>0.05). However, the success rate of lymphoscintigraphy results was associated with the time interval between injection of radio colloid and surgery (P<0.05). The success rate of surgical identification of axillary SLN was associated with the imaging of hot spots by lymphoscintigraphy (P<0.05). Conclusion: Preoperative lymphoscintigraphy in SLNB in breast cancer patients has significant clinical value. 99mTc-SC has a better detection rate and guidance value in SLN detection of breast cancer. It is an effective guide for surgery and should be brought to the attention of clinicians.