Xin Jiang Medical University
Xin Jiang Medical University
Jia H.,Xin Jiang Medical University |
Liu J.W.,Xin Jiang Medical University |
Ufur H.,Xinjiang Medical University |
He G.S.,Shanghai University |
And 2 more authors.
Pharmacognosy Magazine | Year: 2011
Objectives: To evaluate the antihypertensive effect of Xinjiang red raspberry fruit ethyl acetate extract (EER) on spontaneously hypertensive rats (SHR) and its possible mechanism from antioxidant perspective. Materials and Methods: The SHR rats were randomly divided into 3 groups, and treated with EER low dose (EERL, 100 mg/kg/d), high dose (EERH, 200 mg/kg/d), and water (SHR) through gastric gavage daily for 5 weeks. Another 8 age-matched male Wistar-Kyoto rats were used as normotensive group (WKY). The systolic blood pressure (SBP) was measured by noninvasive tail-cuff method once a week. At the end of the treatment, blood samples were collected and serum concentrations of nitric oxide (NO), superoxide dismutase (SOD), malondialchehyche (MDA), and plasma endothelin (ET) were determined. Results: Treatment of SHR rats with EER lowered the blood pressure compared with that treated with water (SHR), and the high dose showed more significant reduction in blood pressure. Treatment of SHR rats with EER increased serum NO and SOD levels and lowered ET and MDA levels. As compared with control group, NO levels were increased significantly in EERL (P < 0.01), SOD was elevated more significantly in both EERL and EERH (P < 0.01); MDA was decreased significantly in EERH group (P < 0.05), whereas plasma ET decreased more significantly in the EERH group (P < 0.05). Conclusions: The red raspberry extracts demonstrated a dose-dependent antihypertensive effects in SHR and this may be related to increased NO activation and improved vascular endothelial dysfunction via antioxidation. These results confirmed that raspberries rich in polyphenols have potential cardiovascular protective effects.
Ni G.-H.,Central South University |
Ni G.-H.,Xin Jiang Medical University |
Chen J.-F.,Central South University |
Chen X.-P.,Central South University |
Yang T.-L.,Central South University
Pharmazie | Year: 2011
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP450) products of arachidonic acid and EETs are endogenous lipid mediators synthesized by the vascular endothelium which perform important biological functions, including vasodilation, anti-inflammation, antimigratory, and cellular signaling regulations. However, EETs are rapidly degraded by soluble epoxide hydrolase (sEH) to the corresponding diols: dihydroxyeicosatrienoic acids (DHETs), which have little active in causing vasorelaxation. A number of studies have supported that the inhibition of sEH (sEHIs) had cardiovascular protective effects in hypertension, cardiac hypertrophy, atherosclerosis, ischemia-reperfusion injury, and ischemic stroke. Moreover, sEHIs could slow the progression of inflammation, protect end-organ damage and prevent ischemic events, also, attenuate endothelial dysfunction, suggesting that the pharmacological blockade of sEH might provide a broad and novel avenue for the treatment of many cardiovascular diseases.
Liu C.,Central South University |
Liu Z.,Central South University |
Chiu H.F.K.,Chinese University of Hong Kong |
Carl T.W.C.,Chung Yuan Christian University |
And 8 more authors.
BMC Psychiatry | Year: 2013
Background: Malingering detection has emerged as an important issue in clinical and forensic settings. The Structured Interview of Reported Symptoms-2 (SIRS-2) was designed to assess the feigned symptoms in both clinical and non-clinical subjects. The aim of the study was to examine the reliability and validity of the Chinese version of this scale.Methods: Two studies were conducted to evaluate the reliability and validity of the Chinese Version of SIRS-2. In Study one, with a simulation design, the subjects included a. 40 students asked to simulate symptoms of mental illness; b. 40 general psychiatric inpatients and c. 40 students asked to reply to questions honestly. Scales scores for feigning symptoms among three groups were carried out for discriminant validity of the Chinese Version of SIRS-2. Minnesota Multiphasic Personality Inventory-2(MMPI-2) was administered in 80 undergraduate students. In Study two, with a known-groups comparison design, scales scores for feigning symptoms were compared between 20 suspected malingerers and 80 psychiatric outpatients from two forensic centers using the Chinese Version of SIRS-2.Results: The Chinese Version of SIRS-2 demonstrated satisfactory internal consistency in both study one and two. In study one, criterion validity of this scale was supported by its significantly positive correlation with the MMPI-2 (r = 0.282 ~ 0.481 for Infrequency), and by its significantly negative correlation with the MMPI-2 (r = -0.255 ~ -0.519 for Lie and -0.205 ~ 0.391 for Correction). Scores of 10 out of 13 subscales of the Chinese Version of SIRS-2 for simulators were significantly higher than scores of honest students and general psychiatric patients. In study two, the mean scores of the Chinese Version of 13 subscales for suspected malingerers were significantly higher than those of psychiatric outpatients. For discriminant validity, it yielded a large effect size (d = 1.80) for the comparison of the participant groups in study one and two. Moreover, the sensitivity (proportion of malingerers accurately identified by the measure) and specificity (proportion of people accurately classified as responding honestly) of the Chinese version of SIRS-2 in the detection of malingering in these two studies are acceptable.Conclusions: The Chinese version of the SIRS-2 has good psychometric properties and is a valid and reliable tool for detection of malingering in Chinese populations. © 2013 Liu et al.; licensee BioMed Central Ltd.
Rexiati M.,Xin Jiang Medical University |
Mutalifu A.,Xin Jiang Medical University |
Azhati B.,Xin Jiang Medical University |
Wang W.,Xin Jiang Medical University |
And 3 more authors.
PLoS ONE | Year: 2014
Echinococcosis (CE) is an infection which is caused by the larval stage of a tapeworm and is endemic in stockbreeding regions of developing countries. The kidney is the most commonly affected organ in the urinary tract. However, reports on renal hydatid disease are limited in the literature, and usually there are no specific clinical characteristics and promising operative methods. The purpose of this study is to assess the most appropriate surgical technique for the patient with urinary tract CE. We retrospectively analyzed thirty patients with renal hydatid cysts who received different surgical treatments in the urology department of the First Affiliated Hospital of Xinjiang Medical University from February 1985 to April 2010. Twenty patients were males and ten were females. The diagnostic accuracy was 74%, 87.5%, and 66.6% respectively by using of ultrasound, CT, and laboratory tests. Thirty patients were followed up for 1-15 years after surgery. One patient experienced a recurrence of renal CE. The ultrasound, CT, and immunological tests are an important means of diagnosis. The surgical treatment principle of renal hydatid should be based on residual renal function, hydatid cyst size, number, location, and surgical techniques to determine the surgical plan to retain the renal function. © 2014 Rexiati et al.
Wu L.,Fudan University |
Zhang H.,Guang dong Jiaying Medical College |
Liao L.,Xin jiang Medical University |
Dadihan T.,Xin jiang Medical University |
And 2 more authors.
Microscopy Research and Technique | Year: 2013
The morphology of the trigeminal ganglion in human fetus was investigated by means of the tract-tracing method using the lipophilic dye DiI-C18-(3) (1,1′-double octadecane 3,3,3′3′-tetramethyl indole carbonyl cyanine-perchlorate), hematoxylin-eosin (HE) stain, and three-dimensional computer reconstruction models. The trigeminal ganglion was flat in the dorsoventral direction, and DiI staining revealed that the trigeminal ganglion cells were somatotopically distributed in the ganglion in a way that reflected the mediolateral order of the three branches. Ganglion cells of the ophthalmic nerve were distributed in the anteromedial part of the trigeminal ganglion, those of the mandibular nerve were in the posterolateral part, and those of the maxillary nerve were localized in the intermediate part. DiI labeled both ganglion cells and nerve fibers in the trigeminal ganglion; the ganglion cells varied in size and appeared as round- or oval-shaped, the neurites connected the cell soma, and some bipolar neurons were also observed. The number of embryonic trigeminal ganglion cells did not significantly change with gestational age, but the cell diameter, area, and perimeter significantly increased. The motor root leaves the pons, runs along the sensory root, passes the ventral surface of the ganglion, and finally runs together with the mandibular nerve. The findings reported here elucidate the morphology, development, and somatotopic organization of the trigeminal ganglion and reveal the trigeminal nerve motor root pathway along the trigeminal ganglion and mandibular nerve in the human fetus. © 2013 Wiley Periodicals, Inc.
Meng C.-R.,Xin Jiang Medical University |
Zhang Q.,Xin Jiang Medical University |
Wang J.-L.,Xin Jiang Medical University |
Gu T.,Xin Jiang Medical University |
Zhang Z.-X.,Xin Jiang Medical University
International Journal of Clinical and Experimental Medicine | Year: 2016
Objectives: Recent investigations demonstrated that oxidative stress a crucial role in the etiology of acute aortic dissection (AAD). The levels of fructosamine and glycosylated hemoglobin (HbA1c) have been considered as marker to reflect oxidative stress in various diseases. Therefore, this study was planned to investigate the levels of fructosamine and HbA1c in patients with thoracic ADD. Methods: The study sample included 235 consecutive patients for suspected thoracic ADD, a definitive and reliable diagnosis of thoracic ADD was established in 70 of 235 suspected thoracic ADD patients. Results: The levels of serum fructosamine, HbA1c and random blood glucose were significantly higher in thoracic ADD than in those without. There were no statistically differences between the two groups with respect to age and gender, random blood glucose, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), total protein (TP), low density lipoprotein-cholesterol (LDL-C), triglyceride (TG) and total cholesterol (TC). The correlation analysis showed no correlation between random blood glucose and fructosamine, HbA1c in patients with thoracic AAD. Of note, increased fructosamine and HbA1c levels were associated with thoracic ADD in logistic regression analysis (OR=1.251, P<0.001, 95% CI: 1.060-1.480; OR=2.330, P=0.005, 95% CI: 1.420-3.281). The receiver operating characteristics (ROC) curve analysis of fructosamine and HbA1c exhibited some significant results in estimating thoracic ADD patients. Conclusions: Our data suggest that the increased levels of fructosamine and HbA1c are associated with thoracic ADD, and the results indicate that increased levels of fructosamine and HbA1c may be risk factor of thoracic ADD. © 2016, E-Century Publishing Corporation. All rights reserved.
Luo J.,Xin Jiang Medical University
Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] | Year: 2010
To study the effects of telmisartan on voltage dependant potassium channel (Kv) expression in lymphocytes from spontaneously hypertensive rat (SHR). Peripheral blood was collected from male SHR aged 16 and 4 weeks. Peripheral lymphocytes were separated from heparinized whole blood by standard Ficoll-Hypaque density gradient centrifugation. The whole-cell Kv currents were recorded with patch-clamp technique in the absence and presence of telmisartan(10, 30, 100 μmol/L). Real-time PCR was used to determine Kv1.3 mRNA expression in lymphocytes. (1) The currents density of Kv was higher in lymphocytes from 16 weeks-old SHR [ (119.0 ± 9.6) pA/pF] than from 4 weeks-old SHR [(59.0 ± 7.2) pA/pF, P < 0.05]. (2) Currents density was positively correlated with systolic blood pressure in 16 weeks-old SHR (r = 0.837, P < 0.05). (3) The lymphocytes Kv 1.3 mRNA expression was significantly higher in 16-weeks-old SHR than in 4-weeks-old SHR (P < 0.05). (4) Telmisartan reduced the whole-cell Kv currents in a concentration-dependent manner (10.5 ± 3.4)% at 10 μmol/L, (45.8 ± 3.7)% at 30 μmol/L and (81.6 ± 4.2)% at 100 μmol/L, P < 0.01. The lymphocyte Kv channel is upregulated in 16 weeks-old SHR suggesting a role of Kv in the pathophysiology of hypertension. Kv current in lymphocyte could be significantly blocked by telmisartan in a concentration dependent manner.
Feng Y.,Xin Jiang Medical University |
Bian W.,Xin Jiang Medical University |
Mu C.,Xin Jiang Medical University |
Xu Y.,Xin Jiang Medical University |
And 3 more authors.
Journal of Endocrinological Investigation | Year: 2014
Objective: To establish reference intervals using an optimized statistical method by collecting available laboratory data of thyroid stimulating hormone (TSH), and then to verify with the laboratory-present reference intervals. Methods: TSH RIs of the total population and different races, genders, age, source of sample are established through improved Hoffmann and Katayev's method with TSH test results data from Jan 2010 to April 2012 were collected, and finally conduct comparative verification with the laboratory present RIs. Results: According to the improved method, we get various RIs of different sample populations. On comparing with the laboratory current RI (0.270-4.200 mIU/L) most reference change values (RCV) were within acceptable limits. Only lower limit of Han male, Uygur male and outpatient male populations outwith acceptable limits. On excluding the different values, finally, the new RI by the optimized statistical method is 0.233-4.979 mIU/L. Because the new RI expanded the current RI and was not different from the current RI, it was indicated that new RI could be used to verify the laboratory current RIs and seen as the current RI's confidence interval (CI). Inference: TSH RIs established by optimized Hoffmann's and Katayev's methods is viable and can be used to verify RIs provided by manufacturers or other laboratories. © Italian Society of Endocrinology (SIE) 2013.
PubMed | Xin Jiang Medical University
Type: Journal Article | Journal: Zhonghua xin xue guan bing za zhi | Year: 2010
To study the effects of telmisartan on voltage dependant potassium channel (Kv) expression in lymphocytes from spontaneously hypertensive rat (SHR).Peripheral blood was collected from male SHR aged 16 and 4 weeks. Peripheral lymphocytes were separated from heparinized whole blood by standard Ficoll-Hypaque density gradient centrifugation. The whole-cell Kv currents were recorded with patch-clamp technique in the absence and presence of telmisartan(10, 30, 100 mol/L). Real-time PCR was used to determine Kv1.3 mRNA expression in lymphocytes.(1) The currents density of Kv was higher in lymphocytes from 16 weeks-old SHR [ (119.0 9.6) pA/pF] than from 4 weeks-old SHR [(59.0 7.2) pA/pF, P < 0.05]. (2) Currents density was positively correlated with systolic blood pressure in 16 weeks-old SHR (r = 0.837, P < 0.05). (3) The lymphocytes Kv 1.3 mRNA expression was significantly higher in 16-weeks-old SHR than in 4-weeks-old SHR (P < 0.05). (4) Telmisartan reduced the whole-cell Kv currents in a concentration-dependent manner (10.5 3.4)% at 10 mol/L, (45.8 3.7)% at 30 mol/L and (81.6 4.2)% at 100 mol/L, P < 0.01.The lymphocyte Kv channel is upregulated in 16 weeks-old SHR suggesting a role of Kv in the pathophysiology of hypertension. Kv current in lymphocyte could be significantly blocked by telmisartan in a concentration dependent manner.