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Luo J.,Xin Jiang Medical University
Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] | Year: 2010

To study the effects of telmisartan on voltage dependant potassium channel (Kv) expression in lymphocytes from spontaneously hypertensive rat (SHR). Peripheral blood was collected from male SHR aged 16 and 4 weeks. Peripheral lymphocytes were separated from heparinized whole blood by standard Ficoll-Hypaque density gradient centrifugation. The whole-cell Kv currents were recorded with patch-clamp technique in the absence and presence of telmisartan(10, 30, 100 μmol/L). Real-time PCR was used to determine Kv1.3 mRNA expression in lymphocytes. (1) The currents density of Kv was higher in lymphocytes from 16 weeks-old SHR [ (119.0 ± 9.6) pA/pF] than from 4 weeks-old SHR [(59.0 ± 7.2) pA/pF, P < 0.05]. (2) Currents density was positively correlated with systolic blood pressure in 16 weeks-old SHR (r = 0.837, P < 0.05). (3) The lymphocytes Kv 1.3 mRNA expression was significantly higher in 16-weeks-old SHR than in 4-weeks-old SHR (P < 0.05). (4) Telmisartan reduced the whole-cell Kv currents in a concentration-dependent manner (10.5 ± 3.4)% at 10 μmol/L, (45.8 ± 3.7)% at 30 μmol/L and (81.6 ± 4.2)% at 100 μmol/L, P < 0.01. The lymphocyte Kv channel is upregulated in 16 weeks-old SHR suggesting a role of Kv in the pathophysiology of hypertension. Kv current in lymphocyte could be significantly blocked by telmisartan in a concentration dependent manner. Source


Rexiati M.,Xin Jiang Medical University | Mutalifu A.,Xin Jiang Medical University | Azhati B.,Xin Jiang Medical University | Wang W.,Xin Jiang Medical University | And 3 more authors.
PLoS ONE | Year: 2014

Echinococcosis (CE) is an infection which is caused by the larval stage of a tapeworm and is endemic in stockbreeding regions of developing countries. The kidney is the most commonly affected organ in the urinary tract. However, reports on renal hydatid disease are limited in the literature, and usually there are no specific clinical characteristics and promising operative methods. The purpose of this study is to assess the most appropriate surgical technique for the patient with urinary tract CE. We retrospectively analyzed thirty patients with renal hydatid cysts who received different surgical treatments in the urology department of the First Affiliated Hospital of Xinjiang Medical University from February 1985 to April 2010. Twenty patients were males and ten were females. The diagnostic accuracy was 74%, 87.5%, and 66.6% respectively by using of ultrasound, CT, and laboratory tests. Thirty patients were followed up for 1-15 years after surgery. One patient experienced a recurrence of renal CE. The ultrasound, CT, and immunological tests are an important means of diagnosis. The surgical treatment principle of renal hydatid should be based on residual renal function, hydatid cyst size, number, location, and surgical techniques to determine the surgical plan to retain the renal function. © 2014 Rexiati et al. Source


Wu L.,Fudan University | Zhang H.,Guang dong Jiaying Medical College | Liao L.,Xin Jiang Medical University | Dadihan T.,Xin Jiang Medical University | And 2 more authors.
Microscopy Research and Technique | Year: 2013

The morphology of the trigeminal ganglion in human fetus was investigated by means of the tract-tracing method using the lipophilic dye DiI-C18-(3) (1,1′-double octadecane 3,3,3′3′-tetramethyl indole carbonyl cyanine-perchlorate), hematoxylin-eosin (HE) stain, and three-dimensional computer reconstruction models. The trigeminal ganglion was flat in the dorsoventral direction, and DiI staining revealed that the trigeminal ganglion cells were somatotopically distributed in the ganglion in a way that reflected the mediolateral order of the three branches. Ganglion cells of the ophthalmic nerve were distributed in the anteromedial part of the trigeminal ganglion, those of the mandibular nerve were in the posterolateral part, and those of the maxillary nerve were localized in the intermediate part. DiI labeled both ganglion cells and nerve fibers in the trigeminal ganglion; the ganglion cells varied in size and appeared as round- or oval-shaped, the neurites connected the cell soma, and some bipolar neurons were also observed. The number of embryonic trigeminal ganglion cells did not significantly change with gestational age, but the cell diameter, area, and perimeter significantly increased. The motor root leaves the pons, runs along the sensory root, passes the ventral surface of the ganglion, and finally runs together with the mandibular nerve. The findings reported here elucidate the morphology, development, and somatotopic organization of the trigeminal ganglion and reveal the trigeminal nerve motor root pathway along the trigeminal ganglion and mandibular nerve in the human fetus. © 2013 Wiley Periodicals, Inc. Source


Meng C.-R.,Xin Jiang Medical University | Zhang Q.,Xin Jiang Medical University | Wang J.-L.,Xin Jiang Medical University | Gu T.,Xin Jiang Medical University | Zhang Z.-X.,Xin Jiang Medical University
International Journal of Clinical and Experimental Medicine | Year: 2016

Objectives: Recent investigations demonstrated that oxidative stress a crucial role in the etiology of acute aortic dissection (AAD). The levels of fructosamine and glycosylated hemoglobin (HbA1c) have been considered as marker to reflect oxidative stress in various diseases. Therefore, this study was planned to investigate the levels of fructosamine and HbA1c in patients with thoracic ADD. Methods: The study sample included 235 consecutive patients for suspected thoracic ADD, a definitive and reliable diagnosis of thoracic ADD was established in 70 of 235 suspected thoracic ADD patients. Results: The levels of serum fructosamine, HbA1c and random blood glucose were significantly higher in thoracic ADD than in those without. There were no statistically differences between the two groups with respect to age and gender, random blood glucose, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), total protein (TP), low density lipoprotein-cholesterol (LDL-C), triglyceride (TG) and total cholesterol (TC). The correlation analysis showed no correlation between random blood glucose and fructosamine, HbA1c in patients with thoracic AAD. Of note, increased fructosamine and HbA1c levels were associated with thoracic ADD in logistic regression analysis (OR=1.251, P<0.001, 95% CI: 1.060-1.480; OR=2.330, P=0.005, 95% CI: 1.420-3.281). The receiver operating characteristics (ROC) curve analysis of fructosamine and HbA1c exhibited some significant results in estimating thoracic ADD patients. Conclusions: Our data suggest that the increased levels of fructosamine and HbA1c are associated with thoracic ADD, and the results indicate that increased levels of fructosamine and HbA1c may be risk factor of thoracic ADD. © 2016, E-Century Publishing Corporation. All rights reserved. Source


Feng Y.,Xin Jiang Medical University | Bian W.,Xin Jiang Medical University | Mu C.,Xin Jiang Medical University | Xu Y.,Xin Jiang Medical University | And 3 more authors.
Journal of Endocrinological Investigation | Year: 2014

Objective: To establish reference intervals using an optimized statistical method by collecting available laboratory data of thyroid stimulating hormone (TSH), and then to verify with the laboratory-present reference intervals. Methods: TSH RIs of the total population and different races, genders, age, source of sample are established through improved Hoffmann and Katayev's method with TSH test results data from Jan 2010 to April 2012 were collected, and finally conduct comparative verification with the laboratory present RIs. Results: According to the improved method, we get various RIs of different sample populations. On comparing with the laboratory current RI (0.270-4.200 mIU/L) most reference change values (RCV) were within acceptable limits. Only lower limit of Han male, Uygur male and outpatient male populations outwith acceptable limits. On excluding the different values, finally, the new RI by the optimized statistical method is 0.233-4.979 mIU/L. Because the new RI expanded the current RI and was not different from the current RI, it was indicated that new RI could be used to verify the laboratory current RIs and seen as the current RI's confidence interval (CI). Inference: TSH RIs established by optimized Hoffmann's and Katayev's methods is viable and can be used to verify RIs provided by manufacturers or other laboratories. © Italian Society of Endocrinology (SIE) 2013. Source

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