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Zhang Z.,Northeastern University | Trinh H.,Northeastern University | Chen Q.,Xin Hua Hospital | Bickmore T.,Northeastern University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

The design of a virtual conversational agent that provides cardiovascular health counseling to hospitalized geriatrics patients in China is described, along with the linguistic and cultural adaptations performed to tailor the agent for China. Results of a preliminary study comparing conversations with the agent to conversations with a geriatrician in a hospital in Shanghai demonstrated high levels of patient acceptance and satisfaction with the agent, although not as high as for the human doctor. © Springer International Publishing Switzerland 2015.

Ajeawung N.F.,Pediatrics Research Unit | Li B.,Xin Hua Hospital | Kamnasaran D.,Pediatrics Research Unit | Kamnasaran D.,Laval University
Clinical and Investigative Medicine | Year: 2010

Purpose: To provide a critical assessment of the clinical translational applications of microRNA (miRNA) genes in medulloblastomas. Methods: Data were obtained from MEDLINE using Boolean-formatted keyword queries. Top articles were selected for critical analyses-depending on the novelty of findings, qualitative assessment of the citation index and relevance to the diagnosis, prognosis and therapeutic targeting of medulloblastomas. Results: MiRNAs, non-protein-coding RNA molecules, negatively regulate gene expression in a sequence-specific manner during biological processes. In the past few years, miRNA genes have emerged as key regulators of not only molecular events involved in normal brain development and function but also in the molecular pathogenesis of medulloblastomas. In this manner, microRNA genes are identified with functional roles as oncogenes and tumor suppressor genes. At least four miRNAs have proven useful in improving the molecular classification of medulloblastomas, and eight others have shown potential in predicting patients' overall prognosis. Moreover, more than 10 miRNA genes can be potentially utilized in therapies against medulloblastomas, using nine recent methods of targetting miRNAs. Conclusion: The quest to identify miRNA genes that are of biological significance in medulloblastomas is on an ongoing venture. Most importantly, these miRNAs have been shown to be of clinical importance for improving the accuracy of diagnosis and prognosis and even developing therapies that can significantly improve patients' overall survival from this deadly disease. © 2010 CIM.

Ji L.,Peking University | Su Q.,Xin Hua Hospital | Feng B.,Tongji University | Shan Z.,Liaoning Medical University | And 3 more authors.
Diabetes Research and Clinical Practice | Year: 2016

Aims: Self monitoring of blood glucose (SMBG) is not widely utilized in insulin-treated patients with type 2 diabetes. In this analysis, we evaluated the current state of SMBG in Chinese adults with type 2 diabetes treated with insulin. Methods: The 2-phase COMPASS study involved 24 centers across 10 provinces and cities in China. In the first phase, a cross sectional survey was carried out in type 2 diabetes patients receiving insulin treatment. The inclusion criteria for the study subjects in the first phase were: type 2 diabetes, insulin treatment for ≥3 months, and age ≥18 years. Evaluation was made on the status of SMBG and insulin therapy in these patients by a questionnaire. Results: A total of 2819 patients (age 58.2 ± 10.8 years; 49.6% females; BMI 24.6 ± 3.4 kg/m2) with insulin-treated type 2 diabetes were recruited in phase I of this study. The majority of patients (80.4%) were receiving insulin treatment for at least 6 months. At baseline, the mean HbA1c was 8.5 ± 1.9% and 54.6% of patients had an HbA1c above 8%. 50.4% of the cohort had diabetes for at least 10 years, and fewer of these patients achieved HbA1c <7.0% (53 mmol/mol). At baseline, 65.8% of patients reported that daily SMBG frequency was performed on a random basis. 59.2% of patients reported that they occasionally, rarely or never follow their physician's instructions regarding SMBG. Hypoglycemia occurred in over 50% of patients, although in 71.8% of patients this was a rare occurrence. Conclusions: There is low utilization of SMBG in Chinese adults with insulin-treated type 2 diabetes, with approximately two-thirds of patients reporting irregular use of SMBG. This is in line with an overall poor level of glycemic control. © 2016.

Sun J.,Shanghai Childrens Medical Center | Zhu Y.J.,Shanghai First Peoples Hospital | Shi C.R.,Xin Hua Hospital | Zhao H.T.,Shanghai Childrens Medical Center | And 2 more authors.
Journal of Endourology | Year: 2010

Purpose: To evaluate the usefulness of laparoscopic surgery in the management of urachal remnants with recurrent infection in infants. Patients and Methods: Eight infants (mean age 9.6 months, range 2-16 months) underwent laparoscopic excision of urachal remnants with recurrent infection between June 2006 and December 2008. During the same period, 10 infants (mean age 13.2, range 4-17 months) underwent open surgery for the same condition. The laparoscopic surgery was performed transperitoneally by using three ports. The urachal remnant was dissected from the umbilicus to the bladder dome and then removed completely. Results: Immediate complications did not develop in any patient. Blood loss, hospital stay, and operative time with laparoscopic surgery were less than those with open surgery. Recurrence did not develop in any patient who underwent laparoscopic surgery, while it did develop in one patient who underwent open surgery. Conclusion: The laparoscopic approach appears to be a safe and effective alternative to open surgery in the management of urachal remnants with recurrent infection in infants. © Copyright 2010, Mary Ann Liebert, Inc.

Gao L.,Peking University | Ji L.,Peking University | Su Q.,Xin Hua Hospital | Feng B.,Tongji University | And 4 more authors.
Diabetes Research and Clinical Practice | Year: 2016

Aims: To evaluate the effect of structured self-monitoring of blood glucose (SMBG) regimen on quality of life (QoL) in poorly controlled insulin-treated patients with type 2 diabetes. Methods: Phase II of the COMPASS trial was a 6-month, multicenter, prospective, single-arm, interventional study. This study recruited 820 outpatients from 19 clinical sites in China who met the following inclusion criteria: type 2 diabetes, insulin treatment for ≥3 months, and age 18-65 years, an HbA1c >8.0% (64 mmol/mol), and willingness to perform SMBG. Subjects were advised to follow a structured SMBG regimen specific to their insulin regimen, and were trained to respond to SMBG readings via lifestyle changes and insulin dose self-adjustment. QoL assessments (SF-36) were performed at baseline and 6 months. Results: Patients with a mean age of 55.13 ± 9.77 years had an average diabetes duration of 9.83 ± 7.05 years and had been receiving insulin therapy for a mean of 45.4 ± 46.79 months. All QoL parameters were significantly improved following structured SMBG after 6 months, most notably the physical role functioning (< 0.0001) and emotional role functioning (< 0.0001) component scores. Overall, 40.6% of patients rated their overall QoL as 'a bit' or a lot better' after structured SMBG compared with 16.5% prior to the intervention (< 0.0001). SMBG also improved overall feelings of wellbeing, with 39.13% of patients believing that their health was deteriorating prior to SMBG compared with only 14.4% of patients after the intervention (< 0.0001). Conclusions: The structured SMBG program in insulin-treated Chinese outpatients with type 2 diabetes significantly improved QoL outcomes. Physical and emotional role functioning are the 2 QoL scales that demonstrate the largest improvement with SMBG. © 2016.

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