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Eyo U.B.,Rutgers University | Gu N.,Rutgers University | Gu N.,Xijing University | De S.,Rutgers University | And 4 more authors.
Journal of Neuroscience | Year: 2015

Extracellular calcium concentrations in the brain fluctuate during neuronal activities and may affect the behavior of brain cells. Microglia are highly dynamic immune cells of the brain. However, the effects of extracellular calcium concentrations on microglial dynamics have not been investigated. Here, we addressed this question in mouse brain slices and in vivo using two-photon microscopy. We serendipitously found that extracellular calcium reduction induced microglial processes to converge at distinct sites, a phenomenon we termed microglial process convergence (MPCs). Our studies revealed that MPCs target neuronal dendrites independent of neuronal action potential firing and is mediated by ATP release and microglial P2Y12 receptors. These results indicate that microglia monitor and interact with neurons during conditions of cerebral calcium reduction in the normal and diseased brain. © 2015 the authors.


Zhu J.Y.,Xijing University
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology | Year: 2011

To observe the efficacy of ursodeoxycholic acid (UDCA) combined with glucocorticoids in the treatment of autoimmune hepatitis-primary biliary cirrhosis (AIH-PBC) overlap syndrome. 19 patients with AIH-PBC overlap syndrome were divided randomly into two groups: initiate combined group and initiate UDCA-monotherapy group. Biochemical responses and pathological features before and after treatment were analyzed retrospectively with student's t test, Wilcoxon rank sum test and Fisher's exact method. In the initiate combination group, biochemical responses in terms of AIH features (ALT decline to normal, IgG is less than or equal to 16 g/L) and PBC features (ALP decline ≥ 40% or to normal) were achieved. In UDCA-monotherapy group, no statistical difference existed in biochemical responses before adding glucocorticoids, whereas the levels of ALT, AST, GLB and IgG decreased significantly when combined with glucocorticoids. No statistical difference of rates of biochemical responses eixted between the two groups, whereas variance could be seen in different pathological stages. Alleviation of inflammatory infiltration after therapy appeared in 3 patients. Combination therapy of UDCA with glucocorticoids could be suitable for AIH-PBC overlap syndrome. Early treatment is of benefit for achieving better biochemical response and pathological improvement.


Chen X.,Xijing University
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2013

To investigate the injury of button battery to nose and discuss its management. Thirteen cases with button battery in nose were reviewed. After the removal of button battery, nasal cavity irrigations were carried out carefully by nasal endoscopy in all cases. Gelfoam full of erythromycin eye ointment was used to cover the injured mucous membrane. Among all the cases, 10 got full recovery without any complication. There are 2 cases of synechia nasal and 1 case of septum perforation. Removal as soon as possible, careful cleaning and systemic drug are necessary. Nose bleed, septum perforation, adhesion and rhinostenosis should be noticed.


Huang Y.-H.,Xijing University | Zhang Q.-H.,Chinese PLA General Hospital
British Journal of Nutrition | Year: 2010

The present study was undertaken to investigate the antioxidant effect of chronic ingestion of genistein (Gen) against neural death in the brain of ovariectomised (Ovx) rats. The rats were randomlydivided into five groups, i.e. sham-operated (sham), Ovx-only, Ovx with 17-oestradiol, Ovx with low (15mg/kg) and high (30mg/kg) doses of Gen (Gen-L and Gen-H), and were orally administered dailywith drugs or vehicle for 6 weeks. The learning and memory abilities were measured by Morris water maze test. Oxidative damages in the brain were evaluated by the level of superoxide dismutase (SOD), malondialdehyde (MDA) and monoamine oxidase (MAO) activities. Neural apoptosis was shown by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining and caspase-3 activity.In the visual learning and memory test, there were no significant differences among the population means of the five groups. While in the probe trial test, the Gen-L group instead of the Gen-H group exhibited reduced escape latency and increased memory frequency than the Ovx group. Although both doses of Gen could reduce acetylcholinesterase activity, only a low dose of Gen could diminish MDA activitysignificantly in frontal cortex and enhance SOD content in the hippocampus. In contrast, MAO content was decreased in the cortex by either dose of Gen, while in the hippocampus, only a high dose of Genappeared to be effective. Interestingly, Gen at both the doses could attenuate the increased number of TUNEL-positive neurons and caspase-3 activity in Ovx rats. These results suggest that Gen confersprotection against Ovx-induced neurodegeneration by attenuating oxidative stress, lipid peroxidation and the mitochondria-mediated apoptotic pathway in a region- and dose-dependent manner.© The Authors 2010.


Wei Z.,Wuhan University | Wang Z.,Xijing University
Kybernetika | Year: 2013

By introducing a feedback control to a proposed Sprott E system, an extremely complex chaotic attractor with only one stable equilibrium is derived. The system evolves into periodic and chaotic behaviors by detailed numerical as well as theoretical analysis. Analysis results show that chaos also can be generated via a period-doubling bifurcation when the system has one and only one stable equilibrium. Based on Lyapunov stability theory, the adaptive control law and the parameter update law are derived to achieve modified function projective synchronized between the extended Sprott E system and original Sprott E system. Numerical simulations are presented to demonstrate the effectiveness of the proposed adaptive controllers.


Zhang Y.,Xijing University | Zhang Y.,Southwest Jiaotong University
Journal of Modern Transportation | Year: 2012

The aerodynamic drag on a train running in an evacuated tube varies with tube air pressure, train speed and shape, as well as blockage ratio. This paper uses numerical simulations to study the effects of different factors on the aerodynamic drag of a train running at subsonic speed in an evacuated tube. Firstly, we present the assumption of a steady state, two dimensional, incompressible viscous flow with lubricity wall conditions. Subsequently, based on the Navier-Stokes equation and the k-ε turbulent models, we calculate the aerodynamic drag imposed on the column train with a 3-meter diameter running under different pressure and blockage ratio conditions in an evacuated tube transportation (ETT) system. The simulation is performed with FLUENT 6.3 software package. An analyses of the simulation results suggest that the blockage ratio for ETT should be in the range of 0.25-0.7, and the tube internal diameter in the range of 2-4 m, with the feasible vacuum pressure in the range of 1-10000 Pa for the future subsonic ETT trains. © 2012 JMT. All rights reserved.


Xi Y.-N.,2nd Hospital of Yulin | Xin X.-Y.,Xijing University | Ye H.-M.,2nd Hospital of Yulin
Asian Pacific Journal of Tropical Medicine | Year: 2014

Objective: To analyze effects of high mobility group AT-hook 2 (HMGA2) on malignant degree, invasion, metastasis, proliferation and cellular morphology of ovarian cancer cells. Methods: Three methods were applied to observe the effect on HMGA2 expression in ovarian cancer cells and ovarian epithelial cells. Results: After the application of siRNA-HMGA2, number of T29A2-cell clones was decreased, there was significant difference compared with the negative control Block-iT. After application of let-7c, number of T29A2+ cell clones was decreased significantly, however, after the application of Anti-let-7, the number of clones restored, and there was no significant difference compared with the negative control group. After interference, the number of T29A2- cells which passed through Matrigel polycarbonate membrane were significantly lower than the negative control group. After the treatment of siRNA-HMGA2, let-7c and sh-HMGA2 respectively, growth and proliferation of T29A2-, T29A2+ and SKOV3 were slower, and the phenomenon was most obvious in SKOV3. Stable interference of HMGA2 induced mesenchymal-epithelial changes in the morphology of SKOV3-sh-HMGA2. Conclusions: HMGA2 can promote malignant transformation of ovarian cancer cells, enhance cell invasion and metastasis, and promote cell growth and proliferation of ovarian cancer cells, which can cause ovarian cancer to progress rapidly and affect the quality of life. © 2014 Hainan Medical College.


Jie L.,Xijing University
Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 | Year: 2015

Link prediction between two nodes in mobile social network plays a critical role in network architecture evolution. In this paper, we firstly construct the mobile social network model, which is dynamic multidimensional network, and then proposed a suitable link prediction method. © 2015 IEEE.


Quan H.W.,Xijing University
Applied Mechanics and Materials | Year: 2013

In bearings-only target localization, observer path have an important effect on the accuracy of target localization. Based on the analysis of Fisher information matrix, an optimal approach to designing observer path is proposed. Observer path derived from the step-by-step optimal algorithm only depends on observer's initial states and state constraints. The optimal path resulted with step-by-step algorithm is demonstrated by computer simulation. Compared with traditional methods, our algorithm is not limited to the number of observations as well as terminating conditions. © (2013) Trans Tech Publications, Switzerland.


Xiao X.,Xijing University | Wang W.,PLA Fourth Military Medical University | Wang Z.,Xijing University
Pediatric Drugs | Year: 2014

Results: The weighted average overall response rate (CR + PR) for the combination of ifosfamide, etoposide and high-dose methotrexate therapy was 62 %, and the tumor control rate (CR + PR + SD) was 92.3 %; the highest of all six regimens. The weighted average overall response rate and tumor control rate of ifosfamide–etoposide therapy (41.7 and 77.9 %, respectively) were the highest of the two-drug regimens. Weighted average overall response rate and tumor control rate for the remaining regimens were 20.5 and 56.8 %, respectively, for cyclophosphamide-etoposide; 30.0 and 73.5 % for ifosfamide, carboplatin, and etoposide; 12.0 and 40.0 % for cyclophosphamide–topotecan; and 14.5 and 36.4 % for gemcitabine–docetaxel.Methods: We performed a search of PubMed and EMBASE to identify published articles reporting on validated clinical outcomes measures (the rate of complete response [CR] and partial response [PR], the rate of stable disease [SD] and progressive disease [PD] and the 5-year overall survival) after chemotherapy in patients with metastatic, relapsed and refractory osteosarcoma. A total of 20 articles were identified and stratified by different regimens. Finally, six regimens that have at least two drugs were reviewed. Weighted averages of each outcome were computed.Summary of Background Data: Despite a large number of publications on outcomes of second-line chemotherapy for osteosarcoma, there is little consensus on efficacy of the therapy.Objective: Our objective was to systematically categorize published evidence for chemotherapy for metastatic, relapsed and refractory osteosarcoma in order to provide an updated and comprehensive analysis of the clinical outcomes.Conclusion: A chemotherapy regimen comprising both a cell cycle-specific drug and a cell cycle-nonspecific drug could increase response rates. The combination of ifosfamide and etoposide therapy is our first choice in two-drug regimens. Regarding three-drug regimens, adding a cell cycle-specific drug to ifosfamide–etoposide therapy may result in a better response rate than adding a cell cycle-nonspecific drug, or any other two-drug regimens in current studies. Hence, we recommend the use of second-line chemotherapy based on the combination ifosfamide–etoposide regimen in patients with metastatic, relapsed and refractory osteosarcoma. © 2014, Springer International Publishing Switzerland.

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