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Liu G.,Xianshuigu Hospital of Jinnan District | Qi C.,Tianjin Medical University | Xu Q.,Xianshuigu Hospital of Jinnan District | Wu B.,Xianshuigu Hospital of Jinnan District | And 2 more authors.
Tumor Biology | Year: 2014

The methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism G1958A has been extensively investigated as a potential risk factor for prostate cancer (PCa), but the results have thus far been inconclusive. This meta-analysis was performed to derive a more precise estimation of the association. A comprehensive search was conducted to identify all case-control studies of MTHFD1 G1958A polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association, and 95 % confidence intervals (CIs) give a sense of the precision of the estimate. Statistical analyses were performed using Review Manage version 5.0 and Stata 10.0. A total of six available studies were considered in the present meta-analysis, with 7,493 patients and 36,941 controls. When all groups were pooled, there was no evidence that G1958A had significant association with PCa under additive, recessive, dominant, and allelic models. This meta-analysis suggests that MTHFD1 G1958A polymorphism might not be a risk factor for PCa. However, further large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis. © 2013 International Society of Oncology and BioMarkers (ISOBM). Source

Du S.-S.,Xianshuigu Hospital of Jinnan District | Sun S.-S.,Xianshuigu Hospital of Jinnan District | Song Y.-F.,Xianshuigu Hospital of Jinnan District | Hao S.-A.,Xianshuigu Hospital of Jinnan District
World Chinese Journal of Digestology | Year: 2015

AIM: To evaluate the clinical effects of emergency endoscopy in the treatment of acute nonvariceal upper gastrointestinal bleeding. METHODS: A retrospective analysis was performed of 126 patients with acute nonvariceal upper gastrointestinal bleeding who were treated by emergency endoscopy or elective endoscopy at our hospital between March 2010 and September 2013. The causes of acute nonvariceal upper gastrointestinal bleeding were analyzed. The rate of bleeding, the success rate of hemostasis, rebleeding rate, surgery rate and hospitalization time were compared in the two groups. RESULTS: The most common cause of acute non-variceal upper gastrointestinal bleeding was peptic ulcer (44.4%), followed by acute gastric mucosal lesions (12.7%) and gastrointestinal cancer (11.9%). A total of 116 (126) cases of bleeding were detected, and the positive rate was 92.1%. The rate of bleeding was significantly higher in the emergency endoscopy group (97.1%) than in the elective endoscopy group (85.7%) (P < 0.05). The rebleeding rate (2.9%), surgical rate (1.5%) and hospitalization time were significantly lower in the emergency endoscopic group than in the elective endoscopy (P < 0.05). CONCLUSION: Emergency endoscopy is convenient, efficient, and less invasive, and is the preferred treatment for acute non-variceal upper gastrointestinal bleeding. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

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