Li L.,Central South University |
Li L.,Hubei University |
Yan J.,Central South University |
Hu K.,Central South University |
And 10 more authors.
Journal of Ethnopharmacology | Year: 2012
Aim of the study: To investigate the protective effects and the underlying mechanism of Eucommia lignans against hypertensive renal injury. Material and methods: Ten-week-old Wistar Kyoto rats and age matched spontaneously hypertension rats were used in the study. The SHR were randomly divided into 4 groups (n = 7 for each group) and received different treatment for 16 weeks, which including saline, Captopril, Epalrestat and Eucommia lignans, respectively. System blood pressures of the rats were monitored once every 4 weeks. N-Acetyl-β-d-glucosaminidase (NAG) activity and the ratio of albumin and urinary creatinine were chosen as the indices of kidney function. Then the structure and renal collagen type III expression of glomerular basement membrane were observed by microscopy and the renal aldose reductase (AR) expression was measured by immunohistochemistry. In vitro, the proliferation of mesangial cells induced by AngII was assayed by MTT, and the mRNA expression of AR was measured by RT-real-time PCR. Results: The renal function, evaluated by NAG enzyme activity and the ratio of albumin to urinary creatinine, was significantly ameliorated by Eucommia lignans treatment. Meanwhile, Eucommia lignans decreased both the protein (P < 0.05) and the mRNA expressed lever of AR (P < 0.05). Eucommia lignans also decreased the high expression of collagen type III in SHR (P < 0.05) and inhibited the proliferation of renal mesangial cells induced by AngII (P < 0.05). Conclusion: Eucommia lignans have protective effects against hypertensive renal injury, and the protective effects may be partly due to inhibition of aldose reductase. © 2011 Elsevier Ireland Ltd.
Xu Y.,Xiangnan College
Neural Processing Letters | Year: 2015
This paper concerns with bidirectional associative memory neural network model with continuously distributed leakage delays. By applying Lyapunov functional method and differential inequality techniques, we establish some sufficient conditions for the existence and exponential stability of periodic solutions for the model, which complement with some recent ones. Moreover, an example and its numerical simulation are given to support the theoretical results. © 2014, Springer Science+Business Media New York.
Huang T.T.,Xiangnan College |
Huang T.T.,Hunan Normal University |
Wu P.X.,Hunan Normal University |
Yu H.W.,Hunan Normal University
Science China: Physics, Mechanics and Astronomy | Year: 2010
Using three different parameterized dark energy models, we reconstruct the properties of dark energy from the latest 397 Sne Ia, CMB and BAO with the present matter density, Ω m0, given prior. We find that, when Ω m0 is not small, for example, Ω m0 = 0.28 or 0.32, an evolving dark energy with a crossing of phantom divide line is favored and this conclusion seems to be model independent. We a l s o find that the evolving properties of dark energy become more and more evident with the increase of Ω m0 given prior. © Science China Press and Springer-Verlag Berlin Heidelberg 2010.
Guo W.,Central South University |
Guo W.,Xiangnan College |
Che Z.,Central South University |
Aimin X.U.,University of Hong Kong |
Zhou Z.,Central South University
Journal of Central South University (Medical Sciences) | Year: 2010
Objective To investigate the changes of serum angiopoietin-like protein 3 ( Angptl3 ) and adiponectin levels in patients with metabolic syndrome (MS) in order to understand their association with the MS. Methods Serum Angptl3 and adiponectin levels were measured by sandwich ELISA in a group of 111 patients with MS and 152 normal controls. Results Serum adiponectin was lower in the MS patients than in the control subjects [4.22(1.01 -23.29) μg/mLvs. 5.41(0.97-22.27) μg/mL, P<0.05]. With regard to serum Angptl3, there was no significant difference between the 2 groups(P >0.05). Serum adiponectin was correlated to Angptl3 and high density lipoprotein-cholesterol ( HDL-C) (P <0.001 ) and negatively correlated to body mass index ( BMI ) , waist circumference ( WC ), waist to hip ratio (WHR), triglyceride (TG), fasting plasma glucose (FBG), fasting insulin (FINS) and homeostatic model assessment method-insulin resistance (HOMA-IR) (P < 0.001). Serum Angptl3 was positively correlated with adiponectin (P <0.001). Serum adiponectin was found to be independently positive determinant for Angptl3 concentrations (b' =0.256, P < 0.001). Adiponectin was inversely correlated with TG and HOMA-IR ( 6′ = - 0.234, -0.145, P<0.001). Conclusion Adiponectin is decreased in MS patients and may be correlated to Angptl3.
Xu Y.,Xiangnan College
Neural Computing and Applications | Year: 2014
In this paper, a class of high-order cellular neural networks model is considered with the introduction of time-varying delays in the leakage terms. By using differential inequality techniques, some very verifiable and practical delay-dependent criteria on the existence and global exponential stability of anti-periodic solution for the model are derived. Even for the model without leakage delays, the criteria are shown to be less conservative than many recent publications. Moreover, some examples and remarks are given to demonstrate the feasibility of our method. © 2013 Springer-Verlag London.
Xu Y.,Xiangnan College
Neural Computing and Applications | Year: 2014
In this paper, based on the exponential dichotomy theory and contraction mapping fixed point theorem, we obtain some sufficient conditions ensuring the global exponential stability of almost periodic solutions for a new generalized cellular neural network model with time-varying delays in leakage (or forgetting) terms. Our results complement some recent ones. Moreover, an illustrative example and its numerical simulation are given to demonstrate the effectiveness of the obtained results. © 2014, Springer-Verlag London.
Wu B.,Xiangnan College |
Li J.,Central South University |
Huang D.,Central South University |
Wang W.,Central South University |
And 6 more authors.
BMC Cancer | Year: 2011
Background: Ezrin is highly expressed in skin cancer and promotes tumor metastasis. Ezrin serves as a promising target for anti-metastasis therapy. The aim of this study is to determine if the flavonoid bacailein inhibits the metastasis of skin cancer cells through Ezrin.Methods: Cells from a cutaneous squamous carcinoma cell line, A431, were treated with baicalein at 0-60 μM to establish the non-cytotoxic concentration (NCC) range for baicalein. Following treatment with baicalein within this range, total Ezrin protein (both phosphorylated and unphosphorylated forms) and phosphorylated-Ezrin (phos-Ezrin) were detected by western blotting, and Ezrin RNA was detected in A431 cells using reverse transcription-polymerase chain reaction (RT-PCR). Thereafter, the motility and invasiveness of A431 cells following baicalein treatment were determined using wound-healing and Boyden chamber invasion assays. Short-interfering RNA (si-RNA) specifically targeting Ezrin was transfected into A431 cells, and a si-RNA Ezrin-A431 cell line was established by G418 selection. This stable cell line was transiently transfected with Ezrin and mutant Ezrin plasmids, and its motilityand invasiveness was subsequently determined to clarify whether bacailein inhibits these processes through Ezrin.Results: We determined the range of NCCs for baicalein to be 2.5-40 μM in A431 cells. Baicalein displayed a dose- and time-dependent inhibition of expressions of total Ezrin and phos-Ezrin within this range NCCs. In addition, it exerted this inhibitory effect through the reduction of Ezrin RNA transcript. Baicalein also inhibited the motility and invasiveness of A431 skin carcinoma cells within the range of NCCs, in a dose- and time-dependent manner. A431 cell motility and invasiveness were inhibited by 73% and 80% respectively when cells were treated with 20 μM baicalein. However, the motility and invasiveness of A431 cells containing the Ezrin mutant were not effectively inhibited by baicalein.Conclusions: Baicalein reduces the migration and invasiveness of A431 cells through the inhibition of Ezrin expression, which leads to the suppression of tumor metastasis. © 2011 Wu et al; licensee BioMed Central Ltd.
Wang X.,Xiangnan College
Nonlinear Analysis: Real World Applications | Year: 2010
In this paper, we study the stability and existence of periodic solutions for a time-varying fishing model with delay Ṅ(t)=N(t)[a(t)/1+(N(θ(t)) K(t))γ-b(t)], and obtain a necessary and sufficient condition for the existence of periodic solutions and "the best possible" conditions for global attractivity for the above equation. These results improve the existing works in the literature. © 2009 Elsevier Ltd. All rights reserved.
PubMed | Hubei University, Hubei Engineering University and Xiangnan College
Type: Letter | Journal: Biomedical and environmental sciences : BES | Year: 2015
In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 g/L, and the prevalence of elevated BLL (EBLL, defined as BLL 100 g/L) was 18.48% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China.
PubMed | Central South University, Guizhou University, Guiyang Medical University, Kaili University and Xiangnan College
Type: | Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | Year: 2016
Chronic arsenic exposure in drinking water is associated with the abnormalities of cardiac tissue. Excessive generation of ROS induced by arsenic has a central role in arsenic-induced cardiotoxicity. (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study was aim to evaluate the effect of EGCG on arsenic-induced cardiotoxicity invivo and invitro. Treatment with NaAsO2 seriously affected the morphology and ultrastructure of myocardium, and induced cardiac injuries, oxidative stress, intracellular calcium accumulation and apoptosis in rats. In consistent with invivo study, the injuries, oxidative stress and apoptosis were also observed in NaAsO2-treated H9c2 cells. All of these effects induced by NaAsO2 were attenuated by EGCG. These results suggest EGCG could attenuate NaAsO2-induced cardiotoxicity, and the mechanism may involve its potent antioxidant capacity.