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Xian, China

Wang M.,Ningxia Medical University | Ma H.,Ningxia Key Laboratory for Cerebrocranial Diseases | Ma H.,Ningxia Medical University | Wang X.,Ningxia Medical University | And 10 more authors.
Radiation Oncology | Year: 2015

Background: The main objective of this study was to evaluate the efficacy of integrating the blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion tensor imaging (DTI) data into radiation treatment planning for high-grade gliomas located near the primary motor cortexes (PMCs) and corticospinal tracts (CSTs). Methods: A total of 20 patients with high-grade gliomas adjacent to PMCs and CSTs between 2012 and 2014 were recruited. The bilateral PMCs and CSTs were located in the normal regions without any overlapping with target volume of the lesions. BOLD-fMRI, DTI and conventional MRI were performed on patients (Karnofsky performance score≥70) before radical radiotherapy treatment. Four different imaging studies were conducted in each patient: a planning computed tomography (CT), an anatomical MRI, a DTI and a BOLD-fMRI. For each case, three treatment plans (3DCRT, IMRT and IMRT_PMC&CST) were developed by 3 different physicists using the Pinnacle planning system. Results: Our study has shown that there was no significant difference between the 3DCRT and IMRT plans in terms of dose homogeneity, but IMRT displayed better planning target volume (PTV) dose conformity. In addition, we have found that the Dmax and Dmean to the ipsilateral and contralateral PMC and CST regions were considerably decreased in IMRT_PMC&CST group (p<0.001). Conclusions: In conclusion, integration of BOLD-fMRI and DTI into radiation treatment planning is feasible and beneficial. With the assistance of the above-described techniques, the bilateral PMCs and CSTs adjacent to the target volume could be clearly marked as OARs and spared during treatment. © 2015 applies to the data made available in this article, unless otherwise stated. Source

Sha S.,PLA Fourth Military Medical University | Xu B.,PLA Fourth Military Medical University | Kong X.,Xian No.1 Hospital | Wei N.,PLA Fourth Military Medical University | And 2 more authors.
Inflammation Research | Year: 2014

Objective: To analyze the in vivo effect of Escherichia coli Nissle 1917 (EcN) with different courses and different doses to Sprague–Dawley rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis.Methods: The probiotic was orally administered with different courses of treatment (with or without pre-administration) and different doses (107–109 CFU/day) to Sprague–Dawley rats with TNBS-induced colitis. Therapeutic effects, levels of cytokine in serum, mRNA and protein expression were analyzed.Results: Oral EcN administration after TNBS-induced improved colitis dose dependently. In parallel, a reduction of disease activity index and colonic MPO activity together with a decreased level of TNF-α and a trend of increased IL-10 expression was detected. Pre-administration of 107CFU/day EcN to TNBS-treated rats resulted in a significant protection against inflammatory response and colons isolated from these rats exhibited a more pronounced expression of ZO-1 than the other groups. In the group of pre-administration of 109CFU/day, the condition was not improved but deteriorated.Conclusions: This study convincingly demonstrates that pre-administration of probiotic EcN with low dose is able to protect colitis of rats and mediate up-regulation of ZO-1 expression, but long-term of high-dose EcN may do harm to colitis. © 2014, Springer Basel. Source

Wang Y.,Xian Jiaotong University | Wang Y.,Key Laboratory of Molecular Cardiology of Shaanxi Province | Xie B.-Q.,Xian Jiaotong University | Xie B.-Q.,Key Laboratory of Molecular Cardiology of Shaanxi Province | And 15 more authors.
Kidney and Blood Pressure Research | Year: 2015

Background/Aims: The aim of our study was to investigate the effect of high-salt diet on the renal expression of renalase and the potential role of the local renin-angiotensin system in this process. Methods: Sprague-Dawley (SD) rats were divided into groups according to salt content in diet and drug treatment as follows: normal-salt diet (NS), high-salt diet (HS), high-salt intake with hydralazine (HS+H), high-salt diet with enalapril (HS+E), and high-salt diet with valsartan (HS+V). The dietary intervention and drugs were given for four weeks. Renin activity and angiotensin II type 1 receptor (AT1R) levels were detected by real-time PCR. Renalase mRNA and protein were also measured. Results: After four weeks, systolic blood pressure and proteinuria were significantly increased in the HS group with respect to the NS group. Dietary salt intake caused a dramatic decrease in renalase expression in the rat kidneys. Renal cortex renin and AT1R increased significantly in the HS and HS+H groups. Urinary protein was positively correlated with renal renin and AT1R levels. However, in the HS+E and HS+V groups, enalapril and valsartan failed to influence renal renalase expression but abolished the increase in proteinuria, renal cortex renin, and AT1R levels with respect to the HS group. Conclusion: This study indicates that high salt intake reduces renal expression, and renal RAS may be not involved in the regulation of renalase in SD rats fed with high-salt diet. © 2015 The Author(s) Published by S. Karger AG. Source

Wei W.,Xian No.1 Hospital | Zhao Y.,Xian No.1 Hospital | Zhang C.-N.,Xian No.1 Hospital
International Eye Science | Year: 2013

AIM: To evaluate the effect of variety factors on the patient's adaptability and subjective evaluation after wearing Menicon-Z rigid gas permeable contact lens (RGPCL). METHODS: Totally 39 patients were recruited in this study. The clinic data including age, gender, spherical, astigmatism, corneal thickness, corneal curvature, basic tear and living areas were analyzed for their impact. Patients evaluated comfort and visual stability after wearing Menicon-Z RGPCL for a month. RESULTS: The average adaptation period after wearing RGPCL was 6.41±4.64 days. The age factor had a significant influence of the adaptation period (F=4.07, P=0.025). Patient's discomfort caused by foreign body sensation (0.62±0.71) and eye dry sense (0.64±0.63) after wearing RGPCL for a month. CONCLUSION: Patients adapted to Menicon-Z RGPCL in about a week. The younger the more easily adapted to the RGPCL. The main impact factor of patient's adaptation period is comfort. Detailed guidance and corresponding treatment is an important means to resolve their symptoms and long-lasting wearing. Copyright 2013 by the IJO Press. Source

Liang H.-C.,Xian No.1 Hospital | Ma T.,Xian No.1 Hospital | Long T.,Xian No.1 Hospital
International Eye Science | Year: 2013

AIM: To compare the prediction errors (PE) in cataract surgery with Lenstar and conventional ultrasound. METHODS: The data of age-related cataract patients were retrospectively analyzed from March, 2013 to June, 2013 in our hospital. Preoperative measurements of ocular biological parameters and calculation of intraocular lens (IOL) degree using SRK/T's formula with ultrasound, keratometry and Lenstar were performed. Cataract extraction combined with IOL implantation in capsule was taken in every patient. Retinoscopy was taken postoperatively after 3 months. Comparison of the two inspection methods for measuring axial length, mean corneal curvature and postoperative refractive PE and absolute value of PE (APE). RESULTS: Preoperative axial length was 24.68±1.70mm and 24.42±1.65mm with Lenstar and ultrasound, respectively, and there was significant difference (t=-12.688, P<0.001) and significant correlation (r=0.992, P<0.001) between different measurement, and the 95% LoA was in the range between -0.18mm and 0.69mm. Preoperative corneal curvature was 44.22±1.03D and 44.19±1.04D with Lenstar and keratometry, respectively, there was no statistical differences between two methods (t=-1.241, P=0.217), but was the significant correlation (r=0.963, P<0.001), and 95% LoA between 0.52D and 0.58D. PE was 0.05±0.23D and -0.35±0.76D with Lenstar and ultrasound, respectively (t=-5.494, P<0.001). APE were 0.18±0.14D and 0.56±0.62D with Lenstar and conventional ultrasound, respectively (t=6.379, P<0.001). CONCLUSION: Accurate ocular biological parameters can be achieved with Lenstar, and postoperative PE is more precise with Lenstar compared with conventional ultrasound. Lenstar can be used for precise calculation of IOL degree in cataract operation. Source

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