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Xi’an, China

Feng N.,Xian Medical University
Chemical Engineering Transactions | Year: 2015

With the characteristics of numerous constraints, large density and high speed of train, High-speed train operation adjustment problem is a typical large-scale combinatorial optimization problem and also a kind of difficult problem of NP. In combination with the characteristic of China's high-speed railway, this paper builds the mathematical model of high-speed railway operation adjustment, and the model is solved and optimized with differential evolution algorithm. The result of the experiment shows that the Differential Evolution has very high rationality and feasibility in solving the high-speed train operation adjustment problem. Copyright © 2015, AIDIC Servizi S.r.l. Source

A new asymmetric bidentate copper(II) complex, CuL2 (HL = 2-((E)-(4-bromophenylimino) methyl)-6-bromo-4-chlorophenol), has been synthesized and characterized by elemental analyses and single-crystal X-ray diffraction. The complex crystallizes in the monoclinic space group P2 1/c with a = 11.218(3), b = 9.355(3), c = 13.449(4) Å, β = 108.722(4)°, V = 1336.8(6) Å 3, Z = 2, D c = 2.008 g/cm 3, μ(MoKa) = 7.024 mm -1, F(000) = 806, S = 0.999, the final R = 0.0342 and wR = 0.0641 for 2611 observed reflections (I > 2s(I)). The central copper(II) is four-coordinate and bonds to two nitrogen and two oxygen atoms from two Schiff base ligands. The complex is linked into a two-dimensional supramolecular structure by weak intermolecular interactions. In addition, DNA-binding properties of the metal complex were investigated using spectrometric titrations and viscosity measurements. The results show that the complex binds with calf-thymus DNA(CT-DNA), presumably via a partial intercalative mode. The intrinsic binding constant of the Cu(II) complex with DNA is 7.335×10 3 M -1. Copyright © 2008 Chinese Journal of Structural Chemistry. Source

Pan X.-W.,Xian Medical University
Fangzhi Gaoxiao Jichukexue Xuebao | Year: 2012

For any positive integer n, let φ(n) and S(n) denote the Euler function and the Smarandache function respectively. For a fixed positive integer k,if x is a positive integer satisfying x>1 and φ(x) = S (xk), then x is called a non-trivial solution of the equation φ(x) = S(xk). Using some elementary number theory methods, it is proved that ( ¡) All non-trivial solutions x of φ(x) = S(xk) satisfy 2k Source

Xue W.,Xian Jiaotong University | Lei J.,Xian Medical University | Li X.,Xian Jiaotong University | Zhang R.,Xian Jiaotong University
Nutrition Research | Year: 2011

Oxidative stress is involved in the development and progression of diabetic nephropathy (DN). Because Trigonella foenum graecum has been reported to have antidiabetic and antioxidative effects, we hypothesized that T foenum graecum seed aqueous extract (TE) restores the kidney function of diabetic rats via its antioxidant activity. Rats were fed diets enriched with sucrose (50%, wt/wt), lard (30%, wt/wt), and cholesterol (2.5%, wt/wt) for 8 weeks to induce insulin resistance. After a DN model was induced by streptozotocin, the rats were administered a low (440 mg/kg), medium (870 mg/kg), or high (1740 mg/kg) dose of TE by oral intragastric intubation for 6 weeks. In TE-treated DN rats, blood glucose, kidney/body weight ratio, serum creatinine, blood urea nitrogen, 24-hour content of urinary protein, and creatinine clearance were significantly decreased compared with nontreated DN rats. Diabetic rats showed decreased activities of superoxide dismutase and catalase, increased concentrations of malondialdehyde in the serum and kidney, and increased levels of 8-hydroxy-2'-deoxyguanosine in urine and renal cortex DNA. Treatment with TE restored the altered parameters in a dose-dependent manner. Furthermore, all of the ultramorphologic abnormalities in the kidney of diabetic rats, including the uneven thickening of the glomerular base membrane, were markedly ameliorated by TE treatment. We conclude that TE confers protection against functional and morphologic injuries in the kidneys of diabetic rats by increasing activities of antioxidants and inhibiting accumulation of oxidized DNA in the kidney, suggesting a potential drug for the prevention and therapy of DN. © 2011 Elsevier Inc. Source

Tu Y.,Fourth Military Medical University | Gao X.,Fourth Military Medical University | Gao X.,Xian Medical University | Gao X.,Shanghai Institute of Technology | And 7 more authors.
Cancer Research | Year: 2013

Malignant gliomas are the most common central nervous system tumors and the molecular mechanism driving their development and recurrence is still largely unknown, limiting the treatment of this disease. Here, we show that restoring the expression of miR-218, a microRNA commonly downregulated in glioma, dramatically reduces the migration, invasion, and proliferation of glioma cells. Quantitative reverse transcription PCR and Western blotting analysis revealed that expression of the stem cell-promoting oncogene Bmi1 was decreased after overexpression of miR-218 in glioma cells. Mechanistic investigations defined Bmi1 as a functional downstream target of miR-218 through which miR-218 ablated cell migration and proliferation. We documented that miR-218 also blocked the self-renewal of glioma stem-like cells, consistent with the suggested role of Bmi1 in stem cell growth. Finally, we showed that miR-218 regulated a broad range of genes involved in glioma cell development, including Wnt pathways that suppress glioma cell stem-like qualities. Taken together, our findings reveal miR-218 as a tumor suppressor that prevents migration, invasion, proliferation, and stemlike qualities in glioma cells. © 2013 American Association for Cancer Research. Source

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