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Xian, China

Kong L.-J.,Xian Gaoxin Hospital
International Journal of Ophthalmology | Year: 2011

AIM: To observe the efficacy and safety of manual small incision cataract surgery (MSICS) in patients from the Republic of the Sudan. METHODS: Three hundreds patients(320 eyes) underwent MSICS with intraocular lens (IOL) implantation after excision of lens nucleus through tunnel incision. RESULTS: At the first day after operation, the uncorrected visual acuity (UCVA) was ≤0.1 in 16 eyes; 0.2-0.5 in 256 eyes; >0.5 in 48 eyes. IOL implantation was performed in 304 eyes (95.0%). CONCLUSION: MSICS is worth being spread because of rapid postoperative recovery, less complication.

Du S.-S.,Xian No.4 Hospital | Duan Q.,Xian Gaoxin Hospital | Zhu Z.-Q.,Xian No.4 Hospital | Liu B.,Xian No.4 Hospital
International Journal of Ophthalmology | Year: 2010

• AIM: To investigate the result of the local retinal photocoagulation in combination with phamacological treatment for patients with non-proliferative diabetic retinopathy( NPDR). • METHODS: Partial photocoagulation with 532 semiconductor green laser has been used on patients with stage III diabetic retinopathy (DR), combined with the administation of drugs to control blood glucose, blood pressure, blood lipid and hemorheology. • RESULTS: Among 185 treated eyes, visual acuity of 168 eyes(90.8%) was improved and stabilized after treatment, decreased visual acuity and complications happened in 17 eyes (9.2%), there was significant difference between the pre-treatment and post treatment. • CONCLUSION: Local retinal photocoagulation combined with drug treatment for patients with NPDR are safe and effective.

Wang W.-H.,Chinese National Institute for the Control of Pharmaceutical and Biological Products | Wang W.-H.,PLA Fourth Military Medical University | Wang W.-H.,State Key Laboratory of Cancer Biology | Jiang C.-L.,PLA Fourth Military Medical University | And 15 more authors.
World Journal of Gastroenterology | Year: 2010

AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC). METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessed to identify the clinical characteristics of FOXP3 in HCC. RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC. CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC.©2010 Baishideng. All rights reserved.

Liu X.-G.,Xian Gaoxin Hospital | Jiang H.-K.,Nuclear Industry 215 Hospital
Biotechnology Letters | Year: 2013

A double-chamber bioreactor has been developed to generate a tissue-engineered osteochondral composite (TEOC). However, a TEOC generally requires two types of cells (i.e. chondrogenic and osteogenic cells). Therefore, the capacity of mesenchymal stem cells (MSCs) as a single-cell source to work within a double-chamber bioreactor and biphasic scaffolds for generating TEOC was investigated. Compared with static culture, the double-chamber bioreactor not only can promote faster cellular proliferation, indicated by the PicoGreen dsDNA assay, SEM and confocal imaging, but also can trigger efficient chondrogenic and osteogenic differentiation of MSCs in biphasic scaffolds simultaneously, evidenced by gene expression. Thus MSCs are promising as the ideal single-cell source and the double-chamber bioreactor is an advanced culture system to generate TEOC. © 2013 Springer Science+Business Media Dordrecht.

Su X.-L.,Xian Medical University | Zhang H.,Shaanxi Provincial Peoples Hospital | Yu W.,Xian Medical University | Wang S.,Xian Medical University | Zhu W.-J.,Xian Gaoxin Hospital
Chinese Journal of Physiology | Year: 2013

Proliferation and migration of vascular smooth muscle cells (VSMCs) are important events in the development of diabetic atherosclerosis. Previous studies have suggested that KCa3.1 channels participate in atherosclerosis and coronary artery restenosis. In the present study, we attempted to clarify the roles of KCa3.1 channels in the proliferation and migration of VSMCs using experimental type-2 diabetes rat serum and aortic smooth muscle cells (SMC) prepared from non-diabetic rats. mRNA and protein levels and current density of KCa3.1 channels were greatly enhanced in cultured VSMCs treated with diabetic serum. In addition, diabetic serum promoted cell proliferation and migration in cultured VSMCs, and the effects were fully reversed in the cells treated with the KCa3.1 channels blocker TRAM-34. In conclusion, serum from diabetic rats increases the expression of KCa3.1 channels and promotes proliferation and migration of VSMCs to possibly participate in vascular remodeling in diabetes. © 2013 by The Chinese Physiological Society and Airiti Press Inc.

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