Xiamen, China
Xiamen, China

Xiamen University , colloquially known as Xia Da ". The university is one of many comprehensive universities directly administered by the Chinese Ministry of Education. In 1995 it was included in the list of the 211 Project for the state key construction; in 2000 it became one of China's higher-level universities designated for the state key construction of the 985 Project.According to University Undergraduates Teaching Assessment and Chinese Universities Evaluation Standings, the university is ranked 11th in China and has maintained the top 20 ranking in China, among which 6 subjects reach A++ level, including economics and management,fine art, law, chemistry, journalism, communication and mathematics.In addition,the school of management is accredited by EQUIS and AMBA. Wikipedia.


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Patent
Xiamen University and Beijing Wantai Biological Pharmacy Enterprise Co. | Date: 2016-11-14

The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.


Patent
Xiamen University | Date: 2014-12-04

The present invention provides a kind of inherent flame retardant rigid polyurethane foam. The production formula comprises 100 to 105 pbw of polyether polyol and reactive phosphorus-containing flame retardant, 2.5 to 3.5 pbw of amine catalyst, 0.8 to 2.5 pbw of tertiary amine catalyst, 0.8 to 2.5 pbw of foam stabilizer, 0.5 to 1.5 pbw of blowing agent, 135 to 150 pbw of isocyanates, and 0.05 to 0.1 pbw of organo-metallic catalyst, wherein the reactive phosphorus-containing flame retardant is 9,10-dihydro-9-oxa-10-phosphaphenanthrene-4-hydroxybenzyl alcohol. The active monomers containing flame retarding elements are introduced into main chain and side chain of PU for modification, which permanently improves the flame retardancy of PU without obvious effect on other performance of PU matrix.


A membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry and treating method thereof, relating to biogas slurry treatment. The membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry is provided with a biogas slurry storage tank, peristaltic pumps, a microalgae cultivating tank, an air pump, a membrane photobioreactor and a hollow fiber membrane. The biogas slurry containing nitrogen and phosphorus that are out of limits is stored in the biogas slurry storage tank, and is driven by a first peristaltic pump to circularly flow in a silicone pipe; a microalgae solution is cultivated under illumination in the microalgae cultivating tank, and is driven by a second peristaltic pump to circularly flow in a silicone pipe, air is fed into the microalgae cultivating tank through the air pump, the biogas slurry and the microalgae solution are converged in the membrane photobioreactor, and the biogas slurry circularly flows inside the hollow fiber membrane pipe and the microalgae solution circularly flows outside the hollow fiber membrane pipe, the two being in a cross flow; and the nitrogen and phosphorus that are out of limits in the biogas slurry penetrate from the inside of the hollow fiber membrane and are absorbed by the microalgae solution outside the membrane, and after cyclical cultivation, nitrogen and phosphorus that are out of limits in the biogas slurry are absorbed, and the discharge standards are achieved.


The present application provides a method for simultaneously synthesizing a biological flocculant with polysaccharide and -PGA as the active components by using Bacillus licheniformis. Bacillus licheniformis is inoculated to a slant culture medium to be cultured; a single colony on a fresh plate is inoculated to a seed culture medium to be cultured; and a seed fermentation broth is inoculated to a fermentation culture medium to be cultured, and then the biological flocculant having two different components is obtained. The flocculant synthesized in the present invention is high in activity and good in thermal stability; and especially, the flocculation effect of polysaccharide is relatively superior under acidic and neutral conditions, and the flocculation activity of -PGA is relatively higher under neutral and alkaline environments, which can satisfy a relatively large pH application range.


Disclosed is a quantitative analysis method based on air pressure detection, which can be used for the high-sensitivity quantitative detection of various targets having inorganic ions, micromolecules and biological macromolecules such as proteins, DNA, and even viruses, bacteria, cells, etc. The present invention catalyzes hydrogen peroxide to generate a large amount of gas using enzymes or nanometer particles, etc.; converts a target molecule detection signal into a gas pressure intensity signal; achieves signal amplification; and finally converts the pressure intensity change into an electrical signal to conduct a reading through a barometer, thereby achieving high-sensitivity quantitative detection. In the present invention, the feasibility, wide applicability and reliability of the present invention are certified through three different detection systems, i.e. an ELISA system, a DNA hydrogel and a functional DNA sensor, respectively, using a barometer.


Gu W.-M.,Xiamen University
Astrophysical Journal | Year: 2015

Based on the no-outflow assumption, we investigate steady-state, axisymmetric, optically thin accretion flows in spherical coordinates. By comparing the vertically integrated advective cooling rate with the viscous heating rate, we find that the former is generally less than 30% of the latter, which indicates that the advective cooling itself cannot balance the viscous heating. As a consequence, for radiatively inefficient flows with low accretion rates such as M ≲ 10-3 MEdd, where MEdd is the Eddington accretion rate, the viscous heating rate will be larger than the sum of the advective cooling rate and the radiative cooling one. Thus, no thermal equilibrium can be established under the no-outflow assumption. We therefore argue that in such cases outflows ought to occur and take away more than 70% of the thermal energy generated by viscous dissipation. Similarly, for optically thick flows with extremely large accretion rates such as M ≳ 10 MEdd, outflows should also occur owing to the limited advection and the low efficiency of radiative cooling. Our results may help to understand the mechanism of outflows found in observations and numerical simulations. © 2015. The American Astronomical Society. All rights reserved.


Jin L.,Xiamen University
Nature communications | Year: 2013

Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the FXR with distinctive properties in modulating coregulator recruitment. The crystal structure of ivermectin complexed with the ligand-binding domain of FXR reveals a unique binding mode of ivermectin in the FXR ligand-binding pocket, including the highly dynamic AF-2 helix and an expanded ligand-binding pocket. Treatment of wild-type mice, but not of FXR-null mice, with ivermectin decreases serum glucose and cholesterol levels, suggesting that ivermectin regulates metabolism through FXR. Our results establish FXR as the first mammalian protein targeted by ivermectin with high selectivity. Considering that ivermectin is a widely used clinical drug, our findings reveal a safe template for the design of novel FXR ligands.


Zhao Y.,Xiamen University | Liang W.,Hefei University of Technology
Chemical Society Reviews | Year: 2012

This tutorial review primarily illustrates rate theories for charge transfer and separation in organic molecules for solar cells. Starting from the Fermi's golden rule for weak electronic coupling, we display the microcanonical and canonical rates, as well as the relationship with the Marcus formula. The fluctuation effect of bridges on the rate is further emphasized. Then, several rate approaches beyond the perturbation limit are revealed. Finally, we discuss the electronic structure theory for calculations of the electronic coupling and reorganization energy that are two key parameters in charge transfer, and show several applications. © 2012 The Royal Society of Chemistry.


Wu B.,Xiamen University | Zheng N.,Xiamen University
Nano Today | Year: 2013

Catalysis and electrocatalysis by noble metal (NM) nanomaterials is typically surface and interface-sensitive. Effective surface and interface control over NM nanomaterials provides important foundation for studies of structure-dependent catalysis which is critical to the design of NM nanocatalysts with optimized catalytic performances for practical applications. In this review, we focus on recent progress in developing wet-chemical strategies to control the surface and interfacial structures of NM nanocrystals for catalytic and electrocatalytic applications. Approaches to control the surface structures of NM nanocrystals are first summarized and demonstrated by representative examples. We then focus discussions on how to control three different interfaces (i.e., metal-metal, metal-oxide and metal-organic interface) on the surface of NM nanocrystals. Finally, conclusions and perspectives are given to propose the challenges in catalysis-driven surface and interface control of NM nanocrystals. © 2013 Elsevier Ltd.


Patent
Xiamen University and Xiamen Innovax Biotech Co. | Date: 2016-08-26

Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

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