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The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-HBV drug), and thus guide the patients to reasonably choose drugs.


Patent
Xiamen Innovax Biotech Co. and Xiamen University | Date: 2014-03-17

The present invention relates to an epitope peptide (or a variant thereof) which can be used in the prevention of respiratory syncytial virus (RSV) infection, a recombinant protein comprising the epitope peptide (or a variant thereof) and a carrier protein, and uses of the epitope peptide (or a variant thereof) and the recombinant protein. The present invention also relates to an antibody against the epitope peptide, a cell line for generating the antibody, and uses thereof. Furthermore, the present invention also relates to a vaccine or a pharmaceutical composition comprising the recombinant protein or the antibody according to the invention, for preventing one or more symptoms associated with RSV infection.


Patent
Xiamen Innovax Biotech Co. and Xiamen University | Date: 2012-06-01

Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.


Patent
Xiamen University and Xiamen Innovax Biotech Co. | Date: 2013-06-24

The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.


Huang S.-J.,Xiamen University | Liu X.-H.,Xiamen Innovax Biotech Company | Zhang J.,Xiamen University | Ng M.-H.,Xiamen University
Current Opinion in Virology | Year: 2014

Rural community of Dongtai City in eastern China is endemic for hepatitis E virus (HEV), with the zoonotic genotype 4 virus predominating. The virus appears to be widely distributed in environment at generally low levels, such that infection is common, but >97% of which are asymptomatic and provoke a modest antibody response. Naturally acquired immunity affords 75% protection against infection, prevents disease caused by primary infection and alleviates severity of the disease caused by the residual infection that had evaded host immune surveillance. The protection, however, is extended to a minority, while leaving the majority of population essentially without the benefits of immune protection. Vaccination affords similar level of protection as does natural immunity, but expands the protective coverage to the entire population. © 2013 Elsevier B.V. All rights reserved. Source

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