Hayward, CA, United States
Hayward, CA, United States
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Patent
Novartis, Jiang and Xia Llc Inc. | Date: 2017-06-14

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.


Patent
Zeng, Xia Llc Inc., YU Inc, Yang, Li and Kong | Date: 2014-06-11

The present invention provides a combined AIDS vaccine for preventing and/or treating AIDS, which consists of four or more different vector-based AIDS vaccines, wherein HIV protein gene comprised in the different AIDS vaccines may be same. A use method of the vaccine comprises inoculation of one AIDS vaccine each time, wherein inoculation of each vaccine may be continuously performed twice, and after sequential application of the four or more vector vaccines, repeated sequential application of the vector vaccines may be performed.


Patent
Xia Llc Inc. | Date: 2015-02-25

A highly polymeric fiber of boron carbide fabricated from the following components: 50-60 parts of boron carbide, 150-193 parts of highly polymeric ethylene emulsion with a concentration of 40%-50%, 116 parts of hydrochloric acid with a concentration of 37%, 3-5 parts of antioxidant, and 7 parts of catalyst, and it is fabricated from the following way: a 2500-2800C high-temperature high-pressure furnace, a high temperature-resistant spinning furnace. The resultant material exhibits performances such as resistance against high temperature and low temperature, anti-acid and anti-base performance, extensibility, wear resistance and anti-impact capability, and resistance against ultraviolet. The highly polymeric fiber of boron carbide may be used in fields such as firearms manufacture, maritime rescue, fire protection and fire fight, anti-bullet and anti-explosion armor, biochemical nuclear industry treatment, and may be extensively applied to civil use, aerospace, military fairs and national defense. The material is recyclable and pollution-free.


A dedicated material for manufacturing a special safety tyre rubber for wheeled combat vehicles and aircrafts in the army, with the following components of the following weight proportion: 28-40 parts of polyisoprene, 19-30 parts of silicone rubber, 15-25 parts of thermoplastic elastomer, 10-18 parts of magnetic powder, 10-15 parts of paraffin oil, 0.8-2 parts of flexibilizer, 5-10 parts of silicone oil, and 0.5-2 parts of antioxidant. The material of the present invention may be used as a carcass material of a special safety tire marching in unfavorable environments such as rough terrain, a lot of sharp foreign matters, and high temperature and open fire. The dedicated material has properties of ordinary tire rubber at a normal temperature, and it also has characteristics such as resistant against high temperature, against burning, against flame and against aging in an extremely hot environment. Furthermore, the material has properties such as resistance against bullets, against prick and against explosion. The material can withstand attack of shells of light-weighted explosives. The dedicated material can be manufactured by a simple fabrication process, and it is recyclable and pollution-free.


A device for eliminating spliced borders/bezels of a liquid crystal display screen by means of edge display, which comprises an edge display unit is arranged on the spliced border/bezel of the liquid crystal display screen, a dodging layer is arranged on the edge display unit to serve as a display surface of the edge display unit, and the dodging layer and a displayable area of the liquid crystal display screen are synthesized and fused to display an original input video image. The edge display unit is fused with the video image of the displayable area of the liquid crystal display screen in an area source mode, and the edge display unit is infused into the liquid crystal display video image well through converting an LED point light source in edge display into an area source; a large view angle of 75 degrees (an included angle with the normal of the liquid crystal display screen) is allowed, that is, the spliced liquid crystal display screen is watched within the range of 150 degrees, and the spliced image is made to tend to be complete after video images originally lost are restored to be displayed; the overall seamless display screen is formed, the technical requirements for transporting, using and splicing are greatly reduced, and application of the seamless display screen is expanded.


A method for pixel to pixel displaying an input video on a spliced display screen is provided. In the spliced display screen, actual physical pixels of a display area of each display screen are distributed on the basis of a physical outer diameter of the display screen according to an nK video standard. The physical outer diameter includes a screen margin/bezel and a display area of a display screen. The physical pixels of the nK video standard are uniformly distributed in the whole physical outer diameter of the display screen with a bezel, including being uniformly distributed in the width of the margin/bezel. The actual physical pixels in the display area of the display screen are fewer than those of the nK video standard, and the width occupied by the missing pixels is consistent with that occupied by the display screen margin/bezel. The method provides the probability of directly playing the nK input video and overcomes the limit that the input video respectively sent to each spliced display screen can be played only after being amplified.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 155.00K | Year: 2016

The search for rare-events, such as double beta decay or dark matter detections, is primarily a fight to reduce the incidence of background events to sufficiently low levels so that the events of interest can be seen. Two major sources of background are trace amounts of radio-impurities found within the materials used to construct, support, and shield these experiments, and the contamination of these materials surfaces caused by exposure to atmospheric radon. Direct detection of alpha emission is necessary to accurately determine the levels of surface contamination on these ultra-pure materials, but currently available screening techniques do not have sufficient sensitivity to characterize these materials at the levels required. The DOE, which is a major supporter of rare-event search activities, therefore has an active interest in the development of ultra low activity materials. By extension, there is also an active interest in developing instrumentation for characterizing such ultra low activity materials, since it is impossible to improve something that cannot be measured. Approach: In this project we are proposing to develop an instrument to effectively characterize radiopure materials for surface alpha emission, an instrument whose lower detection limit will be over 100 times lower than that of the best commercially available instruments. XIA manufactures and sells the UltraLo-1800 alpha particle counter, which represents the current state-of-the-art in low background alpha particle detection. In the proposed approach, we will convert the UltraLo-1800 from an ionization chamber into a time projection chamber, which will allow us to push achievable background rates towards 1 alpha/day/m2, without shielding at the earth’s surface. This enhanced sensitivity will allow for the relatively rapid characterization of ultra-pure materials without having to conduct the measurement underground. Commercial Application & Benefits: If successful, this instrument’s direct benefit will be its support of a variety of rare-event experiments which seek to expand our understanding of the basic principles upon which the universe operates. Moreover, the enhancements made to the capabilities of the UltraLo-1800 will provide a significant performance advantage in other areas, including environmental remediation measurement of alpha radiation, and the semiconductor packing industry where controlling alpha activity from packaging materials is critical to increasing device reliability. Key Words: Low background, alpha particle detector, time projection chamber


Patent
Ding and Xia Llc Inc. | Date: 2016-10-26

A method for three-primary-color combined gamma calibration is disclosed. Three-primary-color combined gamma calibration is applied to two electro-optic display systems with three primary colors having intrinsic wavelengths which are not completely the same or to a single electro-optic display system. Not only the electro-optic nonlinearity is calibrated but also the output dominant wavelengths of the systems are calibrated. This calibration is achieved by way of actively bringing in and superposing other primary color components, and the superposed components are the functions of the calibrated primary colors in the whole color gamut space. Thus, effective migrations occur to output dominant wavelengths of three primary colors of the systems with respect to intrinsic wavelengths or dominant wavelengths of the original three primary colors, so that output dominant wavelengths of two groups of three primary colors with intrinsic wavelengths which are not completely the same of two systems trend to be consistent in the whole color gamut space, or so that the output dominant wavelengths of a single system meets the calibration requirements in the whole color gamut space.


A technique for characterizing the noise behavior of a superconducting tunnel junction (STJ) detector as a function of its applied bias voltage V_(b )by stepping the STJs bias voltage across a predetermined range and, at each applied bias, making multiple measurements of the detectors current, calculating their mean and their standard deviation from their mean, and using this standard deviation as a measure of the STJ detectors noise at that applied bias. Because the method is readily executed under computer control, it is particularly useful when large numbers of STJ detectors require biasing, as in STJ detector arrays In a preferred implementation, the STJ is measured under computer control by attaching it to a digital spectrometer comprising a digital x-ray processor (DXP) coupled to a preamplifier that can set the STJs bias voltage V_(b )using a digital-to-analog converter (DAC) controlled by the DXP.


Patent
Changzhou Globe Co., Chen, Xia Llc Inc. and Wang | Date: 2015-10-07

A brush-less motor is disclosed, comprising a stator, a rotor, a plurality of field-effect tubes, a commutation circuit board, a control circuit board and a motor end cap, wherein the motor end cap comprises a front end cap and a rear end cap which are mutually fixedly connected to form an integrated motor; the plurality of field-effect tubes is directly fixed at the motor front end cap; the commutation circuit board and the control circuit board are both connected to the motor front end cap. The field-effect tubes of the brush-less motor are directly installed on a housing of the motor, ensuring good heat dissipation, saving heat sinks and cost; the integrated brush-less motor runs more smoothly and imposes requirements which are not as high as those imposed by the split brush-less motor on the accuracy of the housing. Thus, the reject ratio of products during batch production is reduced.

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