Sakai, Japan
Sakai, Japan

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Kuriyan R.,National Health Research Institute | Kumar D.R.,National Health Research Institute | R R.,Green Chemical Inc. | Kurpad A.V.,National Health Research Institute
BMC Complementary and Alternative Medicine | Year: 2010

Background: Hibiscus sabdariffa is used regularly in folk medicine to treat various conditions.Methods: The study was a double blind, placebo controlled, randomized trial. Sixty subjects with serum LDL values in the range of 130-190 mg/dl and with no history of coronary heart disease were randomized into experimental and placebo groups. The experimental group received 1 gm of the extract for 90 days while the placebo received a similar amount of maltodextrin in addition to dietary and physical activity advice for the control of their blood lipids. Anthropometry, blood biochemistry, dietary and physical activity were assessed at baseline, day 45 and day 90.Results: While body weight, serum LDL cholesterol and triglyceride levels decreased in both groups, there were no significant differences between the experimental and placebo group.Conclusions: It is likely that the observed effects were as a result of the patients following the standard dietary and physical activity advice. At a dose of 1 gm/day, hibiscus sabdariffa leaf extract did not appear to have a blood lipid lowering effect.Trial Registration: REFCTRI2009000472. © 2010 Kuriyan et al; licensee BioMed Central Ltd.


Shiigi H.,Osaka Prefecture University | Fukuda M.,Osaka Prefecture University | Tono T.,Osaka Prefecture University | Takada K.,Osaka Prefecture University | And 11 more authors.
Chemical Communications | Year: 2014

We demonstrate a simple manipulation of gold nanoparticles that creates a structure-dependent nanometer-scale antenna on the surface of bacteria. Our studies illuminate the concept of the "effective use of light" based on the absorption and emission of light by antennas formed on bacteria. This journal is © the Partner Organisations 2014.


Shiigi H.,Osaka Prefecture University | Muranaka Y.,Osaka Prefecture University | Iwamoto M.,Osaka Prefecture University | Masuda K.,Osaka Prefecture University | And 3 more authors.
Bunseki Kagaku | Year: 2014

A nanometer-sized gold nanoparticle (AuNP)-glucose oxidase (GOx) hybrid has been prepared by a single-step procedure. This paper examines the roles of AuNPs in the enzyme activity of the hybrids by considering electrochemical and fluorescence measurements. The immobilization of the hybrids on a glassy carbon electrode led to an increase in a current response of 2.5 times, compared to that of GOx. On the other hand, there was no difference in the fluorescence intensity based on the production of hydrogen peroxide through the enzyme reaction in between GOx and AuNP-GOx. These results indicate that AuNPs in the hybrid does not affect the enzyme activity, but promotes an electron transfer originated through an enzyme reaction to the electrode. © 2014 The Japan Society for Analytical Chemistry.


Nakao H.,Japan National Institute of Materials Science | Tokonami S.,Osaka Prefecture University | Yamamoto Y.,Green Chemical Inc. | Shiigi H.,Osaka Prefecture University | Takeda Y.,Japan National Institute of Materials Science
Chemical Communications | Year: 2014

We report on a facile method for preparing fluorescent carbon nanowires (CNWs) with pyrolysis of highly aligned DNA nanofibers as carbon sources. Silver nanoparticle (AgNP)-doped CNWs were also produced using pyrolysis of DNA nanofibers with well-attached AgNPs, indicating emission enhancement assisted by localized plasmon resonances. © 2014 the Partner Organisations.


Shiigi H.,Osaka Prefecture University | Shirai S.,Osaka Prefecture University | Fujita T.,Osaka Prefecture University | Morishita H.,Osaka Prefecture University | And 6 more authors.
Journal of the Electrochemical Society | Year: 2013

It is the ultimate goal to accurately place molecules and spaces while building electronic devices using individual molecules. In this paper, we attempt to form a metal-insulator-metal (MIM) junction on micrometer-sized plastic beads that can be placed where desired. Electron tunneling in an MIM junction formed from a two-dimensional network consisting of repeated gold nanoparticle (AuNP)-alkyl chain-AuNP sequences is evaluated by directly measuring the electrical resistivity of the microbead. A plot of the logarithm of the resistivity versus the number of carbon atoms in the alkyl chain (n c = 3-8) in each junction yields identical tunneling coefficients, β, of 8.59 ± 0.09 nm-1. The MIM junction on a microbead can be moved and arranged in any location, which enables the rapid development of miniaturized compact electronic devices. © 2013 The Electrochemical Society. All rights reserved.


Shiigi H.,Osaka Prefecture University | Muranaka Y.,Osaka Prefecture University | Hatsuoka Y.,Osaka Prefecture University | Yamamoto Y.,Osaka Prefecture University | And 2 more authors.
Journal of the Electrochemical Society | Year: 2013

A nanometer-sized organic-inorganic hybrid, similar to a raspberry, comprising a repeated sequence of a three-dimensional gold nanoparticle (AuNP)-aniline oligomer-AuNP arrangement has been prepared by a single-step procedure in an aqueous medium using aniline as a reducing and protecting agent. The nanoraspberry hybrid holds a high density of highly dispersible AuNPs with a mean particle diameter of 5.0 nm, and without any contact with each other because of the linkage formed by aniline oligomers between adjacent AuNPs. The immobilization of the hybrids on a glassy carbon electrode led to the discovery of novel characteristics of the hybrids. The hybrids showed outstanding catalytic activity for the electrochemical reduction of oxygen and oxidation of glucose. This paper examines the roles of AuNPs and aniline oligomers in the development of the electrochemical catalytic property in the raspberry-like hybrid. We found that the aniline oligomer works as a linker to anchor two AuNPs in the hybrids and the individual AuNPs without any contact with each other expresses the electrochemical catalytic activity of the hybrids. © 2013 The Electrochemical Society.

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