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Hollister, CA, United States

Wyatt P.J.,Wyatt Technology Corporation
Analytical Chemistry | Year: 2014

The characterization of nanoparticle size and structure by means of classical light scattering measurements from monodisperse suspensions is examined from both the Rayleigh-Gans (R-G) approximation as well as (for various spherical structures) the exact Lorenz-Mie theory. A means by which the traditional limits of the R-G theory may be extended and simplified is shown by a detailed discussion of the characteristic mean-square radius. This becomes particularly important for irregular particle shapes, where scattering depends on the orientation of such particles with respect to the direction of the incident illumination. A variety of particle structures are addressed, including rods, tubes, ellipsoids, rings, and superellipsoids. © 2014 American Chemical Society.


Some D.,Wyatt Technology Corporation
Biophysical Reviews | Year: 2013

While light scattering has long been applied to the analysis of biomolecular interactions, recent advances have extended the practical use of light scattering techniques to cover a rather broad range of phenomena. In this paper I review essential light scattering theory as applied to specific interactions under thermodynamically ideal conditions and present examples showing how light scattering elucidates the dynamic equilibrium and kinetic behavior of proteins and other biomacromolecules. © 2013 The Author(s).


Patent
Wyatt Technology Corporation | Date: 2013-11-27

A cuvette for use with light scattering detectors is disclosed. A trough or moat within the cuvette can be filled with solvent which is not in fluid contact with the sample to be measured. This solvent moat creates saturated vapor pressure in the chamber preventing evaporation from the sample when the cuvette is capped. The cuvette itself may be made of an inexpensive polymer which can be polished to high optical quality while still being moldable in complex forms capable of enabling further utility, such as extra griping surfaces, identification tabs allowing the detection instrument to determine the cuvette model, and various sample chamber forms. The novel cuvette may have extremely small sample volumes, while allowing significant overfill of the measurement chamber, improving ease of sample loading. The polymers used may be relatively inexpensive, and therefore the cuvette can generally be discarded after a single use.


Patent
Wyatt Technology Corporation | Date: 2013-11-27

A pressure transducer is disclosed wherein no wetted areas have been welded. A cavity is milled into the back of each of the blocks of a material which will make up the body of the transducer. Pickup coils are placed into these cavities and are held in place generally with epoxy cement. With the coils mounted within the sensor body, the surface which will be exposed to the sample or reference fluids is comprised of a single, solid material with no welding joints. Further, as the sensor block half is made of a single, solid material, fluid fitting connections may be machined directly into the body. The pickup coil placed within the improved sensor body may be wound on an open frame of nickel superalloy (NiSA). Another embodiment involves coating or encapsulating the sensing membrane within a soft, non-magnetic material protecting it from corrosion.


Patent
Wyatt Technology Corporation | Date: 2013-05-16

Various embodiments of integrated measurement cell systems for the simultaneous or near simultaneous measurement of light scattering and UV absorption measurements, and methods of their use, are disclosed. In the flow cell implementations, the height of the measurement cell is traversed by the UV beam multiple times by beam directing optics, allowing thereby, the accurate determination of concentration present in the integrated flow cell and allowing the user to select the desired sensitivity which is proportional to the number of passes the beam makes through the cell. Batch implementations also allow for near simultaneous measurement of light scattering and UV absorption within the cuvette. These embodiments aid in the reduction or elimination of errors due to interdetector band broadening while also decreasing the amount of sample required and improving design flexibility of integrated measurement systems.

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