Wuhan, China
Wuhan, China

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Yu J.-G.,Central Hospital of Wuhan | Ye T.,Puai Hospital of Wuhan | Huang Q.,Central Hospital of Wuhan | Feng Y.-F.,Fudan University | And 3 more authors.
Journal of Ophthalmology | Year: 2016

Purpose. To evaluate and compare the subjective sensations reported by patients during first and second cataract extractions. Methods. Consecutive patients undergoing bilateral sequential cataract extraction using phacoemulsification were recruited. Following cataract surgery, patients completed questionnaires designed to evaluate subjective sensations, including anxiety, eye bulges, pain, and light sensitivity. Changes in painful sensations experienced by patients between the two surgeries were also recorded. Comparisons were also performed for each subjective sensation between different age groups (<50, 50-59, 60-69, 70-79, and >79 years). Results. A total of 127 patients were included in the final evaluation. Statistical comparison of the results showed that there were significant differences in perception of anxiety, eye bulges, and pain scores between the first and second cataract surgeries (P < 0.05). However, there was no statistically significant difference for light sensitivity scores between the two surgeries (P = 0.555). The differences in anxiety, perception of eye bulges, pain, and light sensitivity scores between both the surgeries showed no correlation with age (P > 0.05 for all). Conclusions. Our research confirms the common observation that patients with bilateral cataracts often report more ocular discomfort during the second surgery. There are, therefore, additional factors that should be considered upon treating patients with bilateral cataracts, and the provision of preoperative counseling could play an important role in providing adequate patient care. © 2016 Ji-guo Yu et al.


Yu J.-G.,Central Hospital of Wuhan | Mei Z.-M.,Central Hospital of Wuhan | Ye T.,Puai Hospital of Wuhan | Feng Y.-F.,Fudan University | And 4 more authors.
Ophthalmic Research | Year: 2016

Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). Methods: The Cochrane Library, Medline, and Embase were screened using our key words. Results were carefully reviewed to ensure that the included studies met the inclusion/exclusion criteria, and the quality of the studies was assessed using the Newcastle-Ottawa Scale. All included studies categorized patients with OSAHS into 3 groups (mild, moderate, and severe), and measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness. All studies included a healthy control group. The weighted mean differences and 95% confidence intervals were calculated for the continuous outcomes. Results: Ten case-control studies were included in the meta-analysis, consisting of a total of 811 OSAHS group and 868 healthy eyes. A meta-analysis of the data showed that the average RNFL thicknesses in the mild, moderate, and severe OSAHS groups were significantly decreased compared to healthy controls. Additionally, RNFL thickness was significantly reduced in all but the temporal quadrant in the moderate and severe OSAHS groups when compared to healthy controls. Conclusions: On the basis of these results, we suggest that peripapillary RNFL thickness as measured by optical coherence tomography could be a useful tool to monitor and assess the severity of OSAHS in patients. Further studies are required in order to differentiate these RNFL changes from glaucomatous changes. This has not been properly examined in any of the studies we were able to identify. © 2016 S. Karger AG, Basel. Copyright: All rights reserved.


Zhang H.-q.,Wuhan Hospital of Traditional Chinese Medicine | Dai Y.,Wuhan Hospital of Traditional Chinese Medicine | Li H.,Hubei Hospital of Traditional Chinese Medicine | Guo Z.-q.,Puai Hospital of Wuhan | And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Osteopontin (OPN) has a great affinity for matrix metalloproteinase groups-3 (MMP-3). The expression of OPN and MMP-3 may play an important role in bone metabolism. OBJECTIVE: To study the serum MMP-3 and OPN levels and the correlations of MMP-3 and OPN with bone metabolic markers and osteoprotegrin and its ligand in aged postmenopausal Chinese women. METHODS: A total of 120 postmenopausal Chinese female volunteers were divided into three groups: normal bone mineral density, low bone mineral density, and osteoporosis. Serum levels of MMP-3, OPN, osteoprotegrin (OPG), osteoprotegrin ligand (OPGL), bone alkaline phosphate (BAP), osteocalcin, bone cross-linked N-telopeptides of type I collagen (NTx) and bone cross-linked C-telopeptides of type I collagen (CTx) were determined. The ratio of OPN to MMP-3 was also determined. RESULTS AND CONCLUSION: Serum levels of OPN and MMP-3 were significantly higher in the osteoporosis group than in the normal bone mineral density group (P < 0.05). Serum levels of MMP-3 and OPN and OPN/MMP-3 were significantly negatively correlated with OPGL, BAP, and osteocalcin levels, but they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05) in postmenopausal women. In the osteoporosis group, MMP-3, OPN, and the ratio of OPN to MMP-3 were significantly negatively correlated with OPGL, BAP and osteocalcin levels (P < 0.05), and they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05). These findings suggest that the increases in serum level of OPN and ratio of OPN to MMP-3 appear possibly as a concomitant event in high bone turnover state, such as postmenopausal osteoporosis.


Wei Z.,Puai Hospital of Wuhan
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To study the effect of low-dose erythromycin combined with sinus displacement therapy on treating sinusitis in patients with nasopharyngeal carcinoma after radiotherapy. The sinus displacement were used with mixed liquid of metronidazole, protease and dexamethasone, and meantime roxithromycin was orally administered. Effective rate was 97.1% in 35 nasopharyngeal carcinoma patients with sinusitis after radiotherapy. Low-dose erythromycin combined with sinus displacement therapy is effective to treat sinusitis in patients with nasopharyngeal carcinoma after radiotherapy. Its advantages are safe, effective, and easy to do.


Shi Y.,Puai Hospital of Wuhan | Yu C.,Puai Hospital of Wuhan | Zhao B.,Puai Hospital of Wuhan | Peng X.,Puai Hospital of Wuhan | And 2 more authors.
Medical Journal of Wuhan University | Year: 2013

Objective: To observe the feasibility and safety of dexmedetomidine versus that of midazolam applied in auxiliary sedation during brachial plexus blockade. Methods: Eighty cases of selective surgery patients undergone brachial plexus anesthesia were divided randomly and double-blindly into groups A, B, C, and D, which were anaesthetized by midazolam, micro-pump dexmedetomidine, micro-pump dexmedetomidine combined with midazolam, and the load dose and micro-pump dexmedetomidine respectively. MAP, HR, and OAA/S score were recorded before anesthesia (T0), 10 min (T1), 20 min (T2), 30 min (T3), 60 min (T4) during anesthesia, and at the end of operation (T5). Results: Compared with that respectively at T0, MAP, HR, and OAA/S score at T1 decreased in group A (P<0.05), during T1-T5 in group B were stable (P>0.05), and during T1-T4 in group C and group D decreased more apparently (P<0.05). While compared with that respectively in group B, MAP, HR, and OAA/S score during anesthesia (T1-T4) decreased in group C and group D (all P<0.05), and the decrease of these indices was much more significant in group D than in group C (all P<0.05). Conclusion: During brachial plexus blockade, dexmedetomidine combined with midazolam shows satisfying sedative effect, reduces the side effects, and the vital signs of patients during anesthesia are stable.


Wu J.,Puai Hospital of Wuhan | Wang L.,Puai Hospital of Wuhan | Liu Z.,Puai Hospital of Wuhan
Medical Journal of Wuhan University | Year: 2013

Objective: To explore the relationship between insulin resistance and dementia in patients with Parkinson's disease. Methods: 141patients with Parkinson's disease were involved in this study. The fasting blood glucose, fasting blood insulin and the oral glucose tolerance were detected. The insulin resistance index was also calculated by HOMA formula. Furthermore, the cognitive and motor function impairments were also estimated by assessment scales related to Parkinson's disease. In addition, the logistic regression analysis was used to analyze the insulin resistance in patients with Parkinson's disease dementia. Results: Of the all patients, 42.6% (60/141) were Parkinson's disease with dementia, including 38 patients with insulin resistance (63.3%), which were less common in the patients without dementia (30.9%) (P<0.05). Meanwhile, the rate of dementia, HOMA-IR score, UPDRSIII score and Hoehn-Yahr scale in group with Parkinson's disease and dementia were all significantly higher than those in group without dementia (P<0.05). Moreover, multiple logistic regression analysis showed that the HOMA-IR was a risk factor for dementia in Parkinson's disease. Conclusion: It suggests that insulin resistance may be a high risk factor for dementia in Parkinson's disease.


Xu Z.,Puai Hospital of Wuhan
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To explore the influencing factors for curative effect of maxillofacial fractures. Retrospective analysis of the 86 patients for maxillofacial fractures from Jan. 2008 to Dec. 2010 in our hospital, to observe data, sex, type, reason, associated injury, methods of treatment, and so on. The success rate of curing was 95.35%. The length of stay for the 86 patients was from 7 days to 28 days, average 16. 8 days. The type, reason, associated injury, methods of treatment were the influencing factors for curative effect of for maxillofacial fracture. The success rate of curing for different ways of operation were different. Recovery rate of operation was 6.097%, it of expectant treatment was 75%, they were statistical different significantly (P < 0.05). The type, reason, associated injury, methods of treatment were the influencing factors for curative effect of for maxillofacial fracture.


Qiu X.,Puai Hospital of Wuhan | Lin M.,Puai Hospital of Wuhan | Zhang Y.,Puai Hospital of Wuhan
World Chinese Journal of Digestology | Year: 2014

Aim: To assess the clinical effects of trimebutine maleate combined with domperidone in the treatment of diabetic gastroparesis (DGP). Methods: Eighty-six patients with DGP were randomly divided into either an experiment group or a control group. The experiment group was treated with trimebutine maleate combined with domperidone, and the control group was treated with domperidone alone. The clinical effects, gastric emptying half-time (GET1/2), adverse reactions, and relapse were compared for the two groups. Results: The total effective rate for the experiment group was significantly higher than that for the control group (93.02% vs 74.42%, P < 0.05). The GET1/2 post-treatment for the two groups was significantly lower than that priortreatment (124.49 min ± 23.05 min vs 225.62 min ± 21.88 min, 199.46 min ± 23.49 min vs 222.62 min ± 19.08 min, P < 0.05). There was no significant difference in the rate of adverse reactions for the two groups (0.00% vs 4.65%, P > 0.05). The rate of relapse at 2 mo for the experiment group was lower than that for the control group (13.95% vs 51.16%, P < 0.05). Conclusion: Trimebutine maleate combined with domperidone can improve clinical symptoms and GET1/2 in patients with DGP. © 2014 Baishideng Publishing Group Inc. All rights reserved.

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