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Cong E.,Fudan University | Cong E.,Oxford Genetics | Li Y.,Oxford Genetics | Shao C.,Fudan University | And 35 more authors.
Psychological Medicine | Year: 2012

Background Studies in Western countries have repeatedly shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in China?Method Three levels of CSA (non-genital, genital, and intercourse) were assessed by self-report in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression and regression coefficients by linear or Poisson regression.Results Any form of CSA was significantly associated with recurrent MD [OR 3.26, 95% confidence interval (CI) 1.95-5.45]. This association strengthened with increasing CSA severity: non-genital (OR 2.47, 95% CI 1.17-5.23), genital (OR 2.77, 95% CI 1.32-5.83) and intercourse (OR 13.35, 95% CI 1.83-97.42). The association between any form of CSA and MD remained significant after accounting for parental history of depression, childhood emotional neglect (CEN), childhood physical abuse (CPA) and parent-child relationship. Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes and an increased risk for generalized anxiety disorder (GAD; OR 1.92, 95% CI 1.39-2.66) and dysthymia (OR 2.16, 95% CI 1.52-3.09).Conclusions In Chinese women CSA is strongly associated with MD and this association increases with greater severity of CSA. Depressed women with CSA have an earlier age of onset, longer depressive episodes and increased co-morbidity with GAD and dysthymia. Although reporting biases cannot be ruled out, our results are consistent with the hypothesis that, as in Western countries, CSA substantially increases the risk for MD in China. © 2011 Cambridge University Press. Source


Li S.-D.,Wu Dong Hospital of Wuhan | Ji H.-B.,Wu Dong Hospital of Wuhan | Wu J.,Shanghai JiaoTong University | Xu H.-M.,Wuhan Mental Health Center
Chinese Journal of New Drugs | Year: 2016

Objective: To explore the effects of paliperidone palmitate injection and olanzapine on efficacy, social function, prolactin and body mass in patients with schizophrenia. Methods: According to hospital order, the patients were divided into paliperidone palmitate and olanzapine (control) groups with double-blind, dual-mode methods. Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) were assessed to evaluate the changes in symptom and efficacy. Personal and Social Performance Scale (PSP) were used to assess the quality of life and social function. Treatment Emergent Sympton Scale (TESS), laboratory test, the changes in prolactin and body mass were determined to estimate the safety. The efficacy, social function, side effects, laboratory examination, the changes in prolactin and body mass were compared between two groups before treatment and at the ends of the 4th, 8th, 12th and 24th weeks after treatment. Results: Before treatment, the PANSS and PSP scores, prolactin, and body mass were not statistically different between two groups. After treatment, PANSS and CGI were not statistically different between two groups at each period after treatment. However, PSP scores, prolactin and body mass were statistical different between two groups at each period after treatment (P<0.01 or P<0.05). Conclusion: The efficacy of paliperidone palmitate is equal to that of olanzapine in patients with schizophrenia, but paliperidone palmitate is superior to olanzapine on social function at the end of the 24th week after treatment, and less effective on prolactin and body mass than olanzapine. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved. Source


Sun Z.,Xinxiang Medical University | Chen H.,Shanghai JiaoTong University | Su Z.,Second Affiliated Hospital of Jining Medical College | Zhou X.,Hunan Brain Hospital | And 3 more authors.
Alcohol | Year: 2012

We evaluated the reliability, validity, and responsiveness of the Chinese version of the 5th edition Addiction Severity Index (ASI-C-5) in Chinese male alcohol-dependent inpatients. Three hundred and fifty-four inpatients with alcohol dependence from five regions of China were interviewed in person by five trained interviewers using the ASI-C-5. Responses were then analyzed for internal consistency reliability, discriminant validity, criterion validity, and responsiveness. Forty subjects were re-interviewed 7 days later to assess test-retest reliability. The ASI-C-5 had good internal consistency, with an overall standardized Cronbach's alpha of 0.79. The Cronbach's alpha values for internal consistency of domain CSs ranged from 0.48 to 0.95, and were above 0.60 for six domains. The 7 day test-retest reliability was acceptable as evidenced by high Pearson correlation coefficients (0.75-0.92, p < 0.01) for 6 of 7 domain CSs. Correlation coefficients between the seven domain CSs ranged from 0.007 to 0.390 (p < 0.05 or 0.01 two-sided), indicating strong discriminant validity. The correlation coefficient between the alcohol dependence composite score of ASI-C-5 and the Alcohol Use Disorders Identification Test (AUDIT) was 0.69 (p < 0.01), indicating good criterion validity. The frequency of extreme scores was low, except for significant floor effects in the " Drugs" and " Legal Status" domains. Collectively, these findings suggest that the ASI-C-5 exhibited strong reliability, validity, and responsiveness in Chinese male alcohol-dependent inpatients. © 2012 Elsevier Inc. Source


Sun N.,Shanxi Medical University | Li Y.,Oxford Genetics | Cai Y.,Fudan University | Chen J.,Shanghai JiaoTong University | And 32 more authors.
Depression and Anxiety | Year: 2012

Background Although the diagnosis of melancholia has had a long history, the validity of the current DSM-IV definition remains contentious. We report here the first detailed comparison of melancholic and nonmelancholic major depression (MD) in a Chinese population examining in particular whether these two forms of MD differ quantitatively or qualitatively. Methods DSM-IV criteria for melancholia were applied to 1,970 Han Chinese women with recurrent MD recruited from 53 provincial mental health centers and psychiatric departments of general medical hospitals in 41 cities. Statistical analyses, utilizing Student's t-tests and Pearson's π 2, were calculated using SPSS 13.0. Results Melancholic patients with MD were distinguished from nonmelancholic by being older, having a later age at onset, more episodes of illness and meeting more A criteria. They also had higher levels of neuroticism and rates of lifetime generalized anxiety disorder, panic disorder, and social and agoraphobia. They had significantly lower rates of childhood sexual abuse but did not differ on other stressful life events or rates of MD in their families. Discussion Consistent with most prior findings in European and US populations, we find that melancholia is a more clinically severe syndrome than nonmelancholic depression with higher rates of comorbidity. The evidence that it is a more "biological" or qualitatively distinct syndrome, however, is mixed. © 2011 Wiley-Liss, Inc. Source


Zhang J.-D.,Henan Provincial Mental Hospital | Li W.-Q.,Henan Provincial Mental Hospital | Song X.-H.,Henan Provincial Mental Hospital | Lou B.-Y.,Henan Provincial Mental Hospital | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Adenylate cyclase VIII is involved in the promotion of morphine tolerance, withdrawal and enhancement, and plays an important role in plastic changes, such as the advanced long-term enhancement effect, long-term memory and stress adaptation. OBJECTIVE: To explore the changes of adenylate cyclase VIII gene expression in the shell of accumbens nuclei before and after development of chronic morphine-induced conditioned place aversion in a rat through naloxone reminder addiction withdrawal. METHODS: Clean grade Sprague Dawley rats were divided into three groups: morphine+naloxone group, morphine+saline group and saline+naloxone group. Rats in the former one group received intraperitoneal injection of 10 mg/kg morphine continuously for 6.5 days, and intraperitoneal injection of 0.3 mg/kg naloxone; then the conditioned place aversion model was established combined with the conditioned place training. Rats in the latter two groups were injected with the same dose of saline as the morphine+naloxone group. The adenylate cyclase VIII gene expression in the shell of accumbens nuclei was detected with immunohistochemistry method before and after development of chronic morphine-induced conditioned place aversion model. RESULTS AND CONCLUSION: Before chronic morphine-induced conditioned place aversion model establishment, there was no significant difference of the adenylate cyclase VIII gene expression in the shell of accumbens nuclei (F=4.651, P=0.052); after conditioned place aversion establishement, the adenylate cyclase VIII gene expression in the shell of accumbens nuclei in the morphine+naloxone group was significantly higher than that in the morphine+saline group and saline+naloxone group (F=4.874, P=0.028). The results indicate that the changes of adenylate cyclase VIII gene expression may be one of the important molecular underpinnings of the conditioned place aversion. Source

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