Wuhan Licheng Biotechnology Co.

Wuhan, China

Wuhan Licheng Biotechnology Co.

Wuhan, China
Time filter
Source Type

Chen S.,China University of Technology | Wang X.,China University of Technology | Wang C.,China University of Technology | Wang C.,Wuhan Licheng Biotechnology Co. | And 5 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2011

The gel permeation chromatography combined with laser light scattering and refractive index (GPC-LS-RI) online method and (LS) single method researched the molecular weight (M̄w) of konjac glucomannan (KGM) were used by static laser light scattering instrument in this paper. The results show that the determination results of molecular weight of KGM are similar by two methods, the molecular weight of KGM is 2.476×105 g/mol by on-line method measured, and it is 2.508×105 g/mol by single method measured, compared with only 1.3% difference between the two method. And at the same time, the molecular weight distributions of KGM and conformation index were analyzed by online method. While the second Virial coefficient (A2) that characterizes the interaction between KGM molecules and solvent molecules was acquired by single method, which can provide reliable foundation for the molecular chain morphology research of KGM.

Jiang G.-L.,China University of Technology | Wang C.,China University of Technology | Wang C.,Wuhan Licheng Biotechnology Co. | Chen W.-P.,China University of Technology | And 4 more authors.
Wuhan Ligong Daxue Xuebao/Journal of Wuhan University of Technology | Year: 2010

The invitro release properties of NMP were analyzed by konjac glucomannan membrane. The preparation parameters were investigated by evaluation of the NMP release degree, selected and then confirmed the effects such as concentration of KGM, DMSO, mix time, laying-time, and used response surface analysis to optimize preparation parameters of membrane. The results show that four factors have significant impact on the release degree of NMP, and the order is laying-time > KGM concentration > DMSO > mix time. The optimal conditions is 3.0%(w/v) KGM and 0.5 mL DMSO mixed for 12 min and laid for 77 min. The produced smooth membrane has a carrying-drug capacity of (1.63 ± 0.01)%, and the release degree of NMP was 93.169%.

Chen W.-P.,Hubei Engineering University | Jiang G.-L.,Hubei Engineering University | Wang C.,Hubei Engineering University | Wang C.,Wuhan Licheng Biotechnology Co. | And 4 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2010

Konjac glucomannan (KGM) was blended with xanthan gum and alginate sodium in aqueous solution to prepare complex gels(KGM/XAN/ALG, K-X-A). Their property and structure were investigated by texture analysis(TA), infrared spectrum (IR), X-ray, scanning electron microscope (SEM), thermogravimetry analysis(TG). The results show that the stronger hydrogen-bonding interaction among KGM, XAN and ALG is formed, the structure of the complex gels is compact and has higher degree of crystallinity in gastric juice. Although the complex gels still remained network frabic in succus entericus, weaker hydrogen-bonding Interaction makes its structure porous. Taking the complex gel as drug-releasing carrier, nimodipine (NMP) and lansoprazole were used as model drugs to study the properties of K-X-A complex gel of drug-release in succus entericus.

Liu Y.,Hubei Engineering University | Zhang Y.,Hubei Engineering University | Lan J.,Hubei Engineering University | Ke B.,Hubei Engineering University | And 5 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2012

The hydrophobic films of konjac glucomannan fatty acid ester (F-KGM) were prepared with KGM and soybean oil by alkali catalyst. The physico-chemical properties of F-KGM were characterized by UV-VIS spectrophotometer, Fourier transform infrared spectrum (FT-IR), X-ray diffraction, gel permeation chromatography-refractive index-multi-angle laser light scattering detection (GPC/RI/MALLS), thermal analysis (DTA-TG-DTG) and scanning electron microscope (SEM). The results show that the molecular weight (M w̄) of F-KGM is 3.653×10 6 g/mol, which is much higher than the that of KGM (1.619×10 6 g/mol). The increase of M w̄ in F-KGM further supports that the ester linkages are formed during the process. The study also shows that the crystal structure of the KGM is destroyed, its crystallinity gradually decreases and its thermal stability is significantly improved. The F-KGM films that are formed by molecular self-assembly process are slow release materials with hydrophobic property and high stability.

Zheng X.-Y.,Hubei Engineering University | Li X.,Hubei Engineering University | Xiao M.,Hubei Engineering University | Ni X.-W.,Hubei Engineering University | And 3 more authors.
Gongneng Cailiao/Journal of Functional Materials | Year: 2013

The reactant solutions were pumped into tubular reactor by proportioning pumps. After reacting for a predetermine time in the reactor, the reaction solution was sprayed to form drops in the pressure injection device. And then, the drops completed the polymerization reaction and were dried in the continuous phase which was heated in advance. The KSAP granules were prepared in this way. The optimized products which give an absorbency of 411 g/g and whose average diameter was 1.65 mm were obtained by the following condition. The mass ratio of cross linker and initiator to KGM was 0.29 and 0.45, respectively. The inner diameter of the tubular reactor was 4mm meanwhile the length of the reactor was 36 m (reactive time was 25 min). The reactor was heated to 78°C. The pressure offered by the pressure injection device was 0.7 MPa. The continuous phase was polyethylene glycol-600 (PEG-600). The temperature of the continuous phase was 80°C.

Zhou D.,Hubei Engineering University | Ke W.-C.,Huanghelou Research Park | Chen Y.-K.,Huanghelou Research Park | Li D.,Huanghelou Research Park | And 2 more authors.
Gongneng Cailiao/Journal of Functional Materials | Year: 2013

Konjac glucomanman (KGM) xerogels were prepared by sol-gel and freeze-drying method using konjac glucomanman (KGM), starch and other plant polysaccharides as basic materials. The structure and property of this xerogels were systematically investigated by TMS-PRO, SEM, nitrogen adsorption/desorption analysis, water vapor adsorption equilibrium and DSC-TGA. The experimental results show that the KGM xerogels have smooth surface, no shrinkage and collapse. The xerogels show three-dimensional (3-D) porous network structure. The surface area of xerogels was 51.84 m2/g. The average diameter of hole was 50 nm. The xerogels can adsorb moisture under different humidity from RH50% to 80%. Moisture content was from 6%-16%. The xerogels sample can keep the original form after moisture absorption. According to the results, the sample in the 169°C internal stability is well.

Wang X.,Hubei Engineering University | Ke B.-S.,Hubei Engineering University | Ke B.-S.,Wuhan Licheng Biotechnology Co. | Wang C.,Hubei Engineering University | And 7 more authors.
Gongneng Cailiao/Journal of Functional Materials | Year: 2011

Superabsorbent polymer(SAP) was prepared through a novel one-step synthesization. The liquid polymer was squeezed from stress squeeze device and dispersed to granulation. In dispersed phase, granule was dehydration and continuous synthesis. SAP was prepared by grafting sodium acrylate on to konjac glucomannan with potassium peroxydisulfate(K2S2O8), alumina(Al2O3), N, N-methylene bis-acrylamid(MBA) and polyethyleneglycol-600 (PEG-600) as initiator, first step crosslinker, second step crosslinker and dispersed phase respectively. The effect of various experimental conditions on the water absorbency was investigated. The results of Box-Behnken experiment design showed that the granule is capable of absorbing pure water 731g/g when the amount of alumina is 0.245g, the polymerization time is 80min, the amount of MBA is 0.08g, the second crosslink time is 42min, and the drying time is 40min at 70°C.

Loading Wuhan Licheng Biotechnology Co. collaborators
Loading Wuhan Licheng Biotechnology Co. collaborators