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Sun T.,Fudan University | Kalionis B.,Pregnancy Research Center | Lv G.,Wuhan Hospital of Traditional Chinese Medicine | Xia S.,Fudan University | Gao W.,Fudan University
BioMed Research International | Year: 2015

Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology. © 2015 Tao Sun et al. Source


Song C.,Key Laboratory of Chinese Medicine Resource and Compound Prescription | Huang L.,Wuhan Huanghelou Flavors and Fragrances Co. | Huang X.,Key Laboratory of Chinese Medicine Resource and Compound Prescription | Huang R.,Key Laboratory of Chinese Medicine Resource and Compound Prescription | And 5 more authors.
Asian Journal of Chemistry | Year: 2013

Dried tuber of Alisma orientalis (Ze Xie) is a traditional Chinese medicine. It has been characterized by high concentrations of protostane triterpenoids, which are believed to play a crucial role for its clinical curative effect. This study describes a reliable and sensitive method for the analysis of protostane triterpenoids in Dried tuber of Alisma orientalis. The protostane triterpenoids were studied by HPLC/QTOF- mass spectrometry. A total of 28 protostane triterpenoids were simultaneously detected in Q-TOF-MS and 15 of them were newly found in Ze Xie. Especially, we focused on the CID MS/MS fragmentation patterns of 3 major components with different MS/MS collision energy at 15 or 35 eV and obtained extensive fragmentation information in structural elucidation. This is the first report regarding to the CID MS/MS fragmentation patterns of protostane triterpenoids in Ze Xie with both positive and negative modes. The results suggest that the method could be applied to analysis of protostane triterpenoids in Ze Xie and other herbs. Source


Feng J.-P.,Huazhong University of Science and Technology | Yuan X.-L.,Huazhong University of Science and Technology | Li M.,Huazhong University of Science and Technology | Fang J.,Huazhong University of Science and Technology | And 6 more authors.
Colorectal Disease | Year: 2013

Aim: The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC). Method: A total of 422 consecutive CRC patients who received 5-FU-based chemotherapy were retrospectively analysed. Fasting plasma glucose (FPG) levels were determined before each cycle of chemotherapy during active treatment and regular follow-up. The prevalence and characteristics of secondary hyperglycaemia were investigated, with special focus on the clinical outcome. Results: Among the 422 CRC patients, 60 had pre-existing hyperglycaemia. In the remaining 362 with normal FPG levels before chemotherapy, 42 (11.6%) and 41 (11.3%) patients developed diabetes and impaired fasting glucose during the study period. Among the 42 secondary diabetic patients, 22 (52.4%) received anti-diabetes drug therapy, in 7 (16.7%) cases the FPG level returned to normal without any active intervention, and 13 (30.9%) cases received diet control and physiotherapy. Thirty-one (8.6%) patients developed diabetes. Based on the Common Terminology Criteria for Adverse Events, an adverse event over Grade 3 occurred in seven cases during follow-up. Diabetes-related adverse events had a serious negative impact on chemotherapy in six cases. Diabetes-related death occurred in three patients. Conclusions: Secondary diabetes associated with 5-FU-based chemotherapy occurs in around 10% of CRC patients, with a significant negative impact on treatment and clinical outcome. 5-FU-related diabetes should be regarded as a common side effect of 5-FU treatment. © 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland. Source


Li Z.,Wuhan Hospital of Traditional Chinese Medicine | Tong Q.,Huazhong University of Science and Technology | Xu H.,Wuhan Hospital of Traditional Chinese Medicine | Hu L.,Wuhan Hospital of Traditional Chinese Medicine | And 4 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2015

The main purpose of this study was to demonstrate the therapeutic effects and mechanism of TDJW, a modern Chinese medicine prescription developed based on the basic traditional Chinese medicine theory of "tonifying the kidney essence," on the Aβ25-35-induced AD rats. The AD model was established by the intracerebroventricular administrations of Aβ25-35 into the hippocampus CA1 tissue of SD male rats. 72 rats were randomly divided into six groups: sham operation, AD model, donepezil, high TDJW group, medium TDJW group, and low TDJW group. After oral administration of TDJW, the results of Morris water maze and step-down test showed that the learning and memory abilities of AD rats were significantly improved. And biochemical measurement demonstrated that Ach and Glu in hippocampus tissues of AD rats were increased as well. Moreover, the Aβ deposits and p-Tau aggregations in hippocampus CA1 tissues of AD rats were attenuated as observed in the micrographs of immunohistochemistry study, and the results of ELISA indicated that the expressions of TNF-α, IL-1β, and IL-6 in hippocampus tissues were significantly decreased. In conclusion, the present study demonstrated that TDJW could be used as a promising therapeutic agent for the clinical applications of AD treatment in patients. © 2015 Zhijie Li et al. Source


Zhang H.-q.,Wuhan Hospital of Traditional Chinese Medicine | Dai Y.,Wuhan Hospital of Traditional Chinese Medicine | Li H.,Hubei Hospital of Traditional Chinese Medicine | Guo Z.-q.,Puai Hospital of Wuhan | And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Osteopontin (OPN) has a great affinity for matrix metalloproteinase groups-3 (MMP-3). The expression of OPN and MMP-3 may play an important role in bone metabolism. OBJECTIVE: To study the serum MMP-3 and OPN levels and the correlations of MMP-3 and OPN with bone metabolic markers and osteoprotegrin and its ligand in aged postmenopausal Chinese women. METHODS: A total of 120 postmenopausal Chinese female volunteers were divided into three groups: normal bone mineral density, low bone mineral density, and osteoporosis. Serum levels of MMP-3, OPN, osteoprotegrin (OPG), osteoprotegrin ligand (OPGL), bone alkaline phosphate (BAP), osteocalcin, bone cross-linked N-telopeptides of type I collagen (NTx) and bone cross-linked C-telopeptides of type I collagen (CTx) were determined. The ratio of OPN to MMP-3 was also determined. RESULTS AND CONCLUSION: Serum levels of OPN and MMP-3 were significantly higher in the osteoporosis group than in the normal bone mineral density group (P < 0.05). Serum levels of MMP-3 and OPN and OPN/MMP-3 were significantly negatively correlated with OPGL, BAP, and osteocalcin levels, but they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05) in postmenopausal women. In the osteoporosis group, MMP-3, OPN, and the ratio of OPN to MMP-3 were significantly negatively correlated with OPGL, BAP and osteocalcin levels (P < 0.05), and they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05). These findings suggest that the increases in serum level of OPN and ratio of OPN to MMP-3 appear possibly as a concomitant event in high bone turnover state, such as postmenopausal osteoporosis. Source

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