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Zhang Z.,Wuhan Center Hospital
Medical Journal of Wuhan University | Year: 2011

Objective: To review the treatment of 50 cases of intracranial aneurysms and to choose the best way and time for the surgical treatment. Methods: Fifty patients with intracranial aneurysms were treated by open microsurgery, endovascular surgery, or convential medicine treatment. The survivals were followed-up, and the clinical manifestations and angiograms were respectively analyzed. Results: Three of 34 patients treated by microsurgery died, and 8 were in disability. Twelve patients were treated by endovascular treatment, and 4 of them were disabled, while nobody dead. Four patients were only given conventional medical treatment and 3 of them died, 1 disabled. Totally, 6 of these 50 patients were dead (12%) 13 were in disability (26%), and 4 of them were in persistent vegetative state. Conclusion: The patient with intracranial aneurysm needs individual treatment. It is important to choose the correct way and time to treat. Early clipping of aneurysms within three days or giving endovascular treatment can lower the rate of death and disability, and reduce the complications. Source


Kong H.,Hubei University | Ding Z.,Hubei University | Zhu X.-C.,Huazhong University of Science and Technology | Gao X.-Y.,Wuhan No. 1 Hospital | And 4 more authors.
Pancreas | Year: 2011

Objectives: The aim of this present study was to investigate the d-dimer in acute pancreatitis and its associations with triglyceride (TG). Methods: The d-dimer was measured in 45 patients with mild acute pancreatitis, 43 patients with severe acute pancreatitis, and 45 healthy controls. Eighty-eight patients were divided into high and low TG groups based on their TG levels. Twenty outpatients with serumal TG levels higher than 5.65 mM were chosen as hypertriglyceridemia controls. We investigated whether there were any correlations between the d-dimer levels and serumal TG in acute pancreatitis. Results: In 45 patients with mild acute pancreatitis, the d-dimer increased to approximately 2 times over the reference value, whereas in 43 patients with severe acute pancreatitis, the d-dimer level increased to 6 times above the limit; the difference was significant. Both TG and acute pancreatitis could cause an elevation of the d-dimer level, in which TG takes a more important role. The increase in the d-dimer was also directly related to the severity of acute pancreatitis. Conclusions: Plasma concentrations of the d-dimer increase in acute pancreatitis. The increase in TG is probably the main cause of the d-dimer elevation in patients with acute pancreatitis. Copyright © 2011 by Lippincott Williams & Wilkins. Source


Xiong G.,Wuhan Center Hospital | Liu X.,Hubei Institute for Nationalities | Wang L.,Wuhan University
Medical Journal of Wuhan University | Year: 2013

Objective: To profile Survivin expression pattern in mouse endometrium during embryonic implantation process. Methods: Forty-two pregnant mice were divided into seven groups according to different pregnant days (pregnant 0, 3.5, 4.5, 5.5, 6.5, 7.5, and 9 days). Immunohistochemical staining and RT-PCR were employed to detect the protein and mRNA expression of Survivin in mouse endometria. Results: (1) The expression level of Survivin in mouse endometria during the embryo implantation prophase (pregnant 0-day, 3.5 d) were significantly lower than that in embryonic implantation phase (4.5 d, 5.5 d, 6.5 d) (P<0.05). (2) The expression level of Survivin in endometria, after embryonic implantation completion (7.5 d, 9 d), were also significantly lower than that in embryo implantation phase (4.5 d, 5.5 d, 6.5 d) (P<0.05). (3) The expression level of Survivin in mouse endometria seems to be lower during embryonic implantation prophase than in embryonic implantation anaphase, but showed no significant difference (P>0.05). Conclusion: The expression of Survivin in mouse uterus in the embryonic implantation prophase and the embryo implantation anaphase were lower than that in embryonic implantation phase. This change implied that Survivin might be an important factor to influence the embryonic implantation. Source


Xiong G.,Wuhan Center Hospital
Medical Journal of Wuhan University | Year: 2013

Objective: To investigate the safety and effectiveness of synthetic mesh in female pelvic floor reconstruction. Methods: The clinical data were retrospectively analyzed in 76 patients undergone pelvic floor reconstruction in our hospital between Jan. 2009 and Jan. 2010. Of the 76 cases, 46 patients(experiment group) with varied degrees of pelvic floor dysfunctions (uterine prolapse, anterior or posterior vaginal wall prolapse) used synthetic mesh for pelvic floor reconstruction. The other 30 patients (control group) received the traditional pelvic floor reconstruction. Results: The average surgery time was shorter and blood loss was less in experiment group as compared with control group. All patients in experiment group had no recurrence after operation and only two cases had mesh erosion after six months of surgery. However, pelvic floor dysfunctions reoccurred in two cases in control group. Conclusion: The synthetic mesh is a simple method in female pelvic floor reconstruction with shorter operative time, less blood loss, and low rate of recurrence. Source


Zhao J.,Huazhong University of Science and Technology | Zhao J.,Wuhan Center Hospital | Luo Y.,Huazhong University of Science and Technology | Wang X.,Huazhong University of Science and Technology | And 5 more authors.
Acta Haematologica | Year: 2010

Direct interaction between T-suppressor and dendritic cells (DCs) results in DC tolerance by inducing upregulation of immunoglobulin-like transcript (ILT) 3 and ILT4. DCs were treated with a lentiviral vector containing paired immunoglobulin-like B gene (PIR-B) DCs and the effect of PIR-B-DCs on graft-versus-host disease (GVHD) was analyzed after allogeneic bone marrow (BM) transplantation (BMT). Therefore, 1 × 106 recipient-derived PIR-B-DCs were injected into BALB/c (H-2kd) mice using BM-splenocyte grafts from major histocompatibility complex-disparate C57BL/6 (H-2k b). Our results showed that PIR-B-DCs deficient in surface costimulatory molecules had higher PIR-B protein expression than immature DCs and interleukin 10-treated DCs. Survival analysis showed PIR-B-DC cotransplantation resulted in significant prolongation of allograft survival (mean survival time: 46.0 ± 13.6 vs. 17.4 ± 3.6 days in untreated MST; p < 0.01). Furthermore, samples from the liver and skin of a mouse did not show clinical or histological signs of GVHD following the injection of PIR-B-DCs. These results demonstrated that PIR-B-DC cotransplantation may attenuate the severity of GVHD after BMT. Copyright © 2010 S. Karger AG, Basel. Source

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