Time filter

Source Type

Hu Z.-W.,Capital Medical University | Wang Z.-G.,Capital Medical University | Wang Z.-G.,Beijing Normal University | Wu J.-M.,Beijing Normal University | Tan S.-T.,Wu Jing Zong Dui Hospital of Guangdong Province
Multidisciplinary Respiratory Medicine | Year: 2012

Gastroesophageal reflux disease (GERD) is a commonly encountered condition in children, which at times causes respiratory distress, such as asthmatic symptoms, and results in serious morbidity and even mortality. The complexity is sometimes so obscure, that it can cause paradoxical diagnoses and treatment. Here we present two cases of children with difficult-to-treat asthmatic symptoms, which were eventually found to be related to GERD. The two children were treated with anti-reflux procedures and both became symptom free. Literature was also reviewed to shed a light into this complex disease. © 2012 Hu et al.; licensee BioMed Central Ltd.


Cheng Y.,Southern Medical University | Zhang H.,Southern Medical University | Chen R.,Southern Medical University | Yang F.,Southern Medical University | And 7 more authors.
PLoS ONE | Year: 2014

Background: Type 2 diabetes is often accompanied by altered cardiometabolic risk profiles, including abdominal obesity, hypertension, and dyslipidaemia. The association of altered cardiometabolic risk profiles with chronic complications of diabetes is not well investigated. Methods: We recruited 2954 type 2 diabetes patients with a body mass index ≥25 kg/m2 who visited the diabetes clinics of 62 hospitals in 21 cities in Guangdong province of China from August 2011 to March 2012. Demographic characteristics, personal and family medical histories, and data on chronic complications of diabetes were collected. Clinical examinations and laboratory assessment were conducted. Results: Abdominal obesity was found in 91.6% of the study population, elevated blood pressure in 78.3%; elevated serum triacylglycerols in 57.8%, and reduced serum HDL-C in 55.9%. Among the cardiometabolic risk factors, elevated blood pressure was significantly associated with almost all the chronic complications of diabetes. After adjusting for age, gender, duration of diabetes, and HbA1c, elevated blood pressure was significantly associated with diabetic retinopathy (OR 1.63, 95% CI: 1.22-2.19), diabetic nephropathy (OR 3.16, 95% CI: 2.25-4.46), cardiovascular disease (OR 2.71, 95% CI: 1.70-4.32), and stroke (OR 1.90, 95% CI: 1.15-3.12). Abdominal adiposity was significantly associated with diabetic nephropathy (OR 1.39, 95% CI: 1.11-1.74). Elevated triacylglycerols was significantly associated with diabetic retinopathy (OR 1.29, 95% CI: 1.05-1.58) and diabetic nephropathy (OR 1.30, 95% CI: 1.05-1.58). Reduced HDL-C was significantly associated with stroke (OR 1.41, 95% CI: 1.05-1.88). Conclusions: Altered cardiometabolic risk profiles, and elevated blood pressure in particular, were significantly associated with chronic complications in overweight and obese patients with type 2 diabetes. Future studies on the prevention of chronic complications of diabetes might make lowering blood pressure a primary target. © 2014 Cheng et al.


PubMed | Peoples Hospital of Zhongshan City, Wu Jing Zong Dui Hospital of Guangdong Province, Southern Medical University and Shantou University
Type: Journal Article | Journal: PloS one | Year: 2014

Type 2 diabetes is often accompanied by altered cardiometabolic risk profiles, including abdominal obesity, hypertension, and dyslipidaemia. The association of altered cardiometabolic risk profiles with chronic complications of diabetes is not well investigated.We recruited 2954 type 2 diabetes patients with a body mass index 25 kg/m2 who visited the diabetes clinics of 62 hospitals in 21 cities in Guangdong province of China from August 2011 to March 2012. Demographic characteristics, personal and family medical histories, and data on chronic complications of diabetes were collected. Clinical examinations and laboratory assessment were conducted.Abdominal obesity was found in 91.6% of the study population, elevated blood pressure in 78.3%; elevated serum triacylglycerols in 57.8%, and reduced serum HDL-C in 55.9%. Among the cardiometabolic risk factors, elevated blood pressure was significantly associated with almost all the chronic complications of diabetes. After adjusting for age, gender, duration of diabetes, and HbA1c, elevated blood pressure was significantly associated with diabetic retinopathy (OR 1.63, 95% CI: 1.22-2.19), diabetic nephropathy (OR 3.16, 95% CI: 2.25-4.46), cardiovascular disease (OR 2.71, 95% CI: 1.70-4.32), and stroke (OR 1.90, 95% CI: 1.15-3.12). Abdominal adiposity was significantly associated with diabetic nephropathy (OR 1.39, 95% CI: 1.11-1.74). Elevated triacylglycerols was significantly associated with diabetic retinopathy (OR 1.29, 95% CI: 1.05-1.58) and diabetic nephropathy (OR 1.30, 95% CI: 1.05-1.58). Reduced HDL-C was significantly associated with stroke (OR 1.41, 95% CI: 1.05-1.88).Altered cardiometabolic risk profiles, and elevated blood pressure in particular, were significantly associated with chronic complications in overweight and obese patients with type 2 diabetes. Future studies on the prevention of chronic complications of diabetes might make lowering blood pressure a primary target.


Yang Y.,Guangzhou University of Chinese Medicine | Yang Y.,General Hospital of Guangzhou Military Command | Yang Y.,Wu Jing Zong Dui Hospital of Guangdong Province | Huang H.,General Hospital of Guangzhou Military Command | Qiu H.-Z.,Guangzhou University of Chinese Medicine
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: The number of patients in need of organ transplantation in China is increased by more than 10% per year. Due to the lack of voluntary donations, China is facing a more severe donor shortage than other countries. What are the specific reasons for the shortage of donor organs in China? What is the attitude toward organ donation in Chinese citizens? What factors are affecting the implementation of organ donation in Chinese citizens? Objective: To investigate the influence of traditional Chinese ideas on the willing of Chinese citizens toward organ donation after death. Methods:By random cluster sampling, 900 persons selected from different social classes as research objects received questionnaire survey. Self-made questionnaire consisted of cognition, attitude and behavior of the public in face of organ donation. Results and Conclusion: (1) 55.16% of persons thought that the main purpose of organ donation was to help others, 24.22% thought that the main purpose of organ donation was a manifestation of social morality, 11.94% thought that organ donation was the continuation of their lives. (2) There were 70.00% who said donations should be used for the cause of organ transplantation, in order to save more lives, and the average score was 2.53 points; while the number of persons who proposed donor organs would be applied in medical teaching was similar to that in pathological anatomy, and the average score was 1.72 and 1.75, respectively. (3) 65.01% of the public supported cardiopulmonary death standard to judge death, 24.33% supported brain death standard to judge death, and moreover, 10.66% of people did not know what to take. (4) 50.52% of people thought that the main factors affecting the organ donation was traditional Chinese culture and ideas, followed by the donation program and family feelings. The study found that traditional Chinese culture and ideas are the main factor affecting organ donation in the public, most people think that cardiopulmonary death standard is better to judge death and that the main purpose of organ donation is to help others that organ donation should be applied firstly to organ transplantation in order to save more lives.


Xie Q.,Jinan University | Xie Q.,Wu Jing Zong Dui Hospital of Guangdong Province | Liu S.,Jinan University | Liu S.,Zhanjiang Normal University | And 9 more authors.
Dalton Transactions | Year: 2014

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels. © 2014 the Partner Organisations.


Zheng S.,Jinan University | Zheng S.,Chinese University of Hong Kong | Li X.,Jinan University | Zhang Y.,Jinan University | And 6 more authors.
International Journal of Nanomedicine | Year: 2012

Gray selenium (Se) is one of the most widely used Se sources with very limited biocompatibility and bioactivity. In the present study, a simple method for the preparation of ultrasmall selenium nanoparticles (SeNPs) through direct nanolization of gray selenium by polyethylene glycol (PEG) was demonstrated. Monodisperse and homogeneous PEG-SeNPs with ultrasmall diameters were successfully prepared under optimized conditions. The products were characterized using various microscopic and spectroscopic methods, and the results suggest that the amphoteric properties of PEG and the coordination between oxygen and selenium atoms contributed to the formation of ultrasmall nanoparticles. PEG-SeNPs exhibited stronger growth inhibition on drug-resistant hepatocellular carcinoma (R-HepG2) cells than on normal HepG2 cells. Dose-dependent apoptosis was induced by PEG-SeNPs in R-HepG2 cells, as evidenced by an increase in the sub-G1 cell population. Further investigation on the underlying molecular mechanisms revealed that depletion of mitochondrial membrane potential and generation of superoxide anions contributed to PEG-SeNPs-induced apoptotic cell death in R-HepG2 cells. Our results suggest that PEG-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for drug-resistant liver cancer, and the strategy to use PEG200 as a surface decorator could be a highly efficient way to enhance the anticancer efficacy of nanomaterials. © 2012 Zheng et al, publisher and licensee Dove Medical Press Ltd.


Wang J.,Southern Medical University | Chen R.-P.,Southern Medical University | Lei L.,Southern Medical University | Song Q.-Q.,Southern Medical University | And 11 more authors.
Asia Pacific Journal of Clinical Nutrition | Year: 2013

This study investigated the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity. A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. At each hospital, Chinese T2DM patients with central obesity who were aged over 20 years, whose serum uric acid levels were measured, and who had lived in Guangdong Province for ≥1 year, were recruited. Hyperuricemia was defined as serum uric acid >420 μmol/L in men and >360 μmol/L in women. Binary logistic regression was used to assess associated risk factors for hyperuricemia. A total of 2,917 T2DM patients with central obesity took part. The overall prevalence of hyperuricemia was 32.6% (36.1% for women, 28.4% for men). Binary logistic regression analyses demonstrated that women (OR: 1.576; 95% confidence interval (CI): 1.231, 2.018), high BMI (OR: 1.228; 95% CI: 1.094, 1.379), waist circumference (OR: 1.135; 95% CI: 1.009, 1.276), hypertension (OR: 1.603; 95% CI: 1.263, 2.035), high total cholesterol (OR: 1.133; 95% CI: 1.002, 1.281), triglycerides (OR: 1.134; 95% CI: 1.069, 1.203), low HDLcholesterol (OR: 0.820; 95% CI: 0.677, 0.995) and low estimated glomerular filtration rate (OR: 0.840; 95% CI: 0.815, 0.866) were risk factors associated with hyperuricemia. Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR.


Peng W.,Wu Jing Zong Dui Hospital of Guangdong Province | Liu Z.,Southern Medical University
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) without specific surface antigens are often identified according to adhesive growth, osteogenic differentiation, adipogenic differentiation and other biological characteristics. OBJECTIVE: To observe the location and distribution of BMSCs in IgA nephropathy rats. METHODS: Sprague-Dawley rats were randomly divided into three groups: BMSCs group, saline group and control group. IgA nephropathy model was established by the improving method with bovine serum albumin+staphylococcal enterotoxin B+subcutaneous injection of carbon tetrachloride in the former two groups. At the 1 st and 4 th weeks after BMSCs injection, the changes of urine protein, renal function, histopathology and IgA immunofluorescence were observed. BrdU-labeled BMSCs were detected by immunohistochemistry to observe the disposition in the kidney. RESULTS AND CONCLUSION: At the end of the first week of BMSCs transplantation, levels of urine protein and serum creatinine in the BMSCs group were lower than those in the saline group. At the end of the 4 th week, the histopathology and IgA immunofluorescence of BMSCs group had the statistical significance compared with those of the saline group. It was indicated that BMSCs injection contributed to renal repair in rat IgA nephropathy. Some of them located in the mesangium and a few were in tubule and interstitial area. But as time passed, the disposition of BrdU-labeled MSCs in kidney was decreased gradually.


Xie Q.,Jinan University | Xie Q.,Wu Jing Zong Dui Hospital of Guangdong Province | Zhou Y.,Jinan University | Lan G.,Jinan University | And 4 more authors.
Biochemical and Biophysical Research Communications | Year: 2014

X-ray-based radiotherapy represents one of the most effective ways in treating human cancers. However, radioresistance and side effect remain as the most challenging issue. This study describes the design and application of novel selenadiazole derivatives as radiotherapy sensitizers to enhance X-ray-induced inhibitory effects on A375 human melanoma and Hela human cervical carcinoma cells. The results showed that, pretreatment of the cells with selenadiazole derivatives dramatically enhance X-ray-induced growth inhibition and colony formation. Flow cytometry analysis indicates that the sensitization by selenadiazole derivatives was mainly caused by induction of G2/M cell cycle arrest. Results of Western blotting demonstrated that the combined treatment-induced A375 cells growth inhibition was achieved by triggering reactive oxygen species-mediated DNA damage involving inactivation of AKT and MAPKs. Further investigation revealed that selenadiazole derivative in combination with X-ray could synergistically inhibit the activity of thioredoxin reductase-1 in A375 cells. Taken together, these results suggest that selenadiazole derivatives can act as novel radiosensitizer with potential application in combating human cancers. © 2014 Elsevier Inc. All rights reserved.


Xie Q.,Jinan University | Xie Q.,Wu Jing Zong Dui Hospital of Guangdong Province | He L.,Jinan University | Lai H.,Jinan University | And 2 more authors.
RSC Advances | Year: 2014

Radiotherapy has been the primary treatment for cancer along with chemotherapy and surgical therapy for decades. However, radiotherapy still fails to efficiently deracinate the hypoxic tumors because of their insensitivity to X-rays. In the present study, we report that selenocysteine (SeC), an analog of cystine (Cys) through selenium substitution of sulfur, could act as an effective radiosensitizer to enhance the anticancer efficacy of radiotherapy through induction of cancer cell apoptosis. By comparing the ROS generation activity of SeC and Cys, we found that selenium substitution significantly enhances the X-ray-induced ROS overproduction in human cervical cancer HeLa cells. Excess ROS could attack various components of DNA and activated downstream signaling pathways in HeLa cells. Specifically, SeC enhanced the radiation-induced phosphorylation of p53 and p38MAPK pathways, and down-regulation of phosphorylated AKT and ERK, and finally resulted in increased radiation sensitivity and inhibited tumor reproduction. Taken together, this study suggests that selenium substitution could be a novel strategy for design of cancer radiosensitizers. This journal is © the Partner Organisations 2014.

Loading Wu Jing Zong Dui Hospital of Guangdong Province collaborators
Loading Wu Jing Zong Dui Hospital of Guangdong Province collaborators