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Fei H.,Sun Yat Sen University | Ke P.,Sun Yat Sen University | Wang N.,Sun Yat Sen University | Shen H.,Sun Yat Sen University | And 4 more authors.
European Journal of Gynaecological Oncology | Year: 2015

Purpose of investigation: To compare the therapeutic and side effects of using Californium252 (252Cf) neutron brachytherapy with neoadjuvant intra-arterial embolism chemotherapy in combination with surgery for treating Stage Ib2-IIb cervical cancers (CCs). Materials and Methods: Thirty-two Stage Ib2-IIb CC patients were enrolled and randomly divided into two groups from January 2007 to April 2010 in the present Hospital. Prior to surgery within four weeks, a total of 17 cases were treated with 252Cf neutron brachytherapy (700-800 cGy doses at point A) once a week (Group A), and 15 cases were treated by neoadjuvant intra-arterial embolism chemotherapy using a combination of bleomycin, carboplatin, and cyclophosphamide twice (Group B). The clinical symptoms and signs, side effects, and relapse condition follow up until July 2013 were compared between the two groups for the perioperation. Results: Reductions in tumor mass and CR+PR were not significantly different between the groups before the surgery (p > 0.05). Abdominal pain and pelvic adhesions were significantly more severe in Group B (p < 0.05). There were no significant differences in surgical time, blood loss or the other side effects between Groups A and B (p > 0.05). The percentage of pelvic tumor recurrences in Group A was lower than that of the patients in Group B (11.8% vs 20.0%) although with no significant difference at present. No distant metastasis has been found in both two groups. Conclusion: Except for less abdominal pain and pelvic adhesions, 252Cf neutron brachytherapy has perioperative effects similar to those of neoadjuvant intra-arterial embolism chemotherapy. Source

Zheng S.,Jinan University | Zheng S.,Chinese University of Hong Kong | Li X.,Jinan University | Zhang Y.,Jinan University | And 5 more authors.
International Journal of Nanomedicine | Year: 2012

Gray selenium (Se) is one of the most widely used Se sources with very limited biocompatibility and bioactivity. In the present study, a simple method for the preparation of ultrasmall selenium nanoparticles (SeNPs) through direct nanolization of gray selenium by polyethylene glycol (PEG) was demonstrated. Monodisperse and homogeneous PEG-SeNPs with ultrasmall diameters were successfully prepared under optimized conditions. The products were characterized using various microscopic and spectroscopic methods, and the results suggest that the amphoteric properties of PEG and the coordination between oxygen and selenium atoms contributed to the formation of ultrasmall nanoparticles. PEG-SeNPs exhibited stronger growth inhibition on drug-resistant hepatocellular carcinoma (R-HepG2) cells than on normal HepG2 cells. Dose-dependent apoptosis was induced by PEG-SeNPs in R-HepG2 cells, as evidenced by an increase in the sub-G1 cell population. Further investigation on the underlying molecular mechanisms revealed that depletion of mitochondrial membrane potential and generation of superoxide anions contributed to PEG-SeNPs-induced apoptotic cell death in R-HepG2 cells. Our results suggest that PEG-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for drug-resistant liver cancer, and the strategy to use PEG200 as a surface decorator could be a highly efficient way to enhance the anticancer efficacy of nanomaterials. © 2012 Zheng et al, publisher and licensee Dove Medical Press Ltd. Source

Peng W.,Wu Jing Zong Dui Hospital of Guangdong province | Liu Z.,Southern Medical University
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) without specific surface antigens are often identified according to adhesive growth, osteogenic differentiation, adipogenic differentiation and other biological characteristics. OBJECTIVE: To observe the location and distribution of BMSCs in IgA nephropathy rats. METHODS: Sprague-Dawley rats were randomly divided into three groups: BMSCs group, saline group and control group. IgA nephropathy model was established by the improving method with bovine serum albumin+staphylococcal enterotoxin B+subcutaneous injection of carbon tetrachloride in the former two groups. At the 1 st and 4 th weeks after BMSCs injection, the changes of urine protein, renal function, histopathology and IgA immunofluorescence were observed. BrdU-labeled BMSCs were detected by immunohistochemistry to observe the disposition in the kidney. RESULTS AND CONCLUSION: At the end of the first week of BMSCs transplantation, levels of urine protein and serum creatinine in the BMSCs group were lower than those in the saline group. At the end of the 4 th week, the histopathology and IgA immunofluorescence of BMSCs group had the statistical significance compared with those of the saline group. It was indicated that BMSCs injection contributed to renal repair in rat IgA nephropathy. Some of them located in the mesangium and a few were in tubule and interstitial area. But as time passed, the disposition of BrdU-labeled MSCs in kidney was decreased gradually. Source

Wang J.,Southern Medical University | Chen R.-P.,Southern Medical University | Lei L.,Southern Medical University | Song Q.-Q.,Southern Medical University | And 11 more authors.
Asia Pacific Journal of Clinical Nutrition | Year: 2013

This study investigated the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity. A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. At each hospital, Chinese T2DM patients with central obesity who were aged over 20 years, whose serum uric acid levels were measured, and who had lived in Guangdong Province for ≥1 year, were recruited. Hyperuricemia was defined as serum uric acid >420 μmol/L in men and >360 μmol/L in women. Binary logistic regression was used to assess associated risk factors for hyperuricemia. A total of 2,917 T2DM patients with central obesity took part. The overall prevalence of hyperuricemia was 32.6% (36.1% for women, 28.4% for men). Binary logistic regression analyses demonstrated that women (OR: 1.576; 95% confidence interval (CI): 1.231, 2.018), high BMI (OR: 1.228; 95% CI: 1.094, 1.379), waist circumference (OR: 1.135; 95% CI: 1.009, 1.276), hypertension (OR: 1.603; 95% CI: 1.263, 2.035), high total cholesterol (OR: 1.133; 95% CI: 1.002, 1.281), triglycerides (OR: 1.134; 95% CI: 1.069, 1.203), low HDLcholesterol (OR: 0.820; 95% CI: 0.677, 0.995) and low estimated glomerular filtration rate (OR: 0.840; 95% CI: 0.815, 0.866) were risk factors associated with hyperuricemia. Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR. Source

Cheng Y.,Southern Medical University | Zhang H.,Southern Medical University | Chen R.,Southern Medical University | Yang F.,Southern Medical University | And 7 more authors.
PLoS ONE | Year: 2014

Background: Type 2 diabetes is often accompanied by altered cardiometabolic risk profiles, including abdominal obesity, hypertension, and dyslipidaemia. The association of altered cardiometabolic risk profiles with chronic complications of diabetes is not well investigated. Methods: We recruited 2954 type 2 diabetes patients with a body mass index ≥25 kg/m2 who visited the diabetes clinics of 62 hospitals in 21 cities in Guangdong province of China from August 2011 to March 2012. Demographic characteristics, personal and family medical histories, and data on chronic complications of diabetes were collected. Clinical examinations and laboratory assessment were conducted. Results: Abdominal obesity was found in 91.6% of the study population, elevated blood pressure in 78.3%; elevated serum triacylglycerols in 57.8%, and reduced serum HDL-C in 55.9%. Among the cardiometabolic risk factors, elevated blood pressure was significantly associated with almost all the chronic complications of diabetes. After adjusting for age, gender, duration of diabetes, and HbA1c, elevated blood pressure was significantly associated with diabetic retinopathy (OR 1.63, 95% CI: 1.22-2.19), diabetic nephropathy (OR 3.16, 95% CI: 2.25-4.46), cardiovascular disease (OR 2.71, 95% CI: 1.70-4.32), and stroke (OR 1.90, 95% CI: 1.15-3.12). Abdominal adiposity was significantly associated with diabetic nephropathy (OR 1.39, 95% CI: 1.11-1.74). Elevated triacylglycerols was significantly associated with diabetic retinopathy (OR 1.29, 95% CI: 1.05-1.58) and diabetic nephropathy (OR 1.30, 95% CI: 1.05-1.58). Reduced HDL-C was significantly associated with stroke (OR 1.41, 95% CI: 1.05-1.88). Conclusions: Altered cardiometabolic risk profiles, and elevated blood pressure in particular, were significantly associated with chronic complications in overweight and obese patients with type 2 diabetes. Future studies on the prevention of chronic complications of diabetes might make lowering blood pressure a primary target. © 2014 Cheng et al. Source

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