Wound Management Innovation Cooperative Research Center

Brisbane, Australia

Wound Management Innovation Cooperative Research Center

Brisbane, Australia

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Tan A.M.,RMIT University | Tan A.M.,Wound Management Innovation Cooperative Research Center | Fuss F.K.,RMIT University | Fuss F.K.,Wound Management Innovation Cooperative Research Center | And 4 more authors.
Procedia Engineering | Year: 2015

A study was conducted to determine the performance of a low cost plantar measuring device. The aim of the device was to establish an in-shoe measurement system with high resolution and to take relatively accurate measurements. The calibration method for the smart material was established with the use of a Kistler force plate. The coefficient of determination r2 of the force against resistance calibration curve was 0.974. The residual standard deviation amounted to 13.91 N. The r2 value of the repetitive loading experiments amounted to 0.981. The residual standard deviation was 70.35 N for forces larger than 700 N. From the data obtained, the insole is deemed to be sufficiently accurate for quantitative analysis. © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.


Parmar S.,RMIT University | Parmar S.,Wound Management Innovation Cooperative Research Center | Bafekrpour E.,RMIT University | Bafekrpour E.,Wound Management Innovation Cooperative Research Center | And 4 more authors.
Textile Bioengineering and Informatics Symposium Proceedings 2016 - 9th Textile Bioengineering and Informatics Symposium, TBIS 2016, in conjunction with the 6th Asian Protective Clothing Conference, APCC 2016 | Year: 2016

This paper is a feasibility study of using conductive fabric as electrode for flexible pressure sensors. A new low-cost textile-based pressure sensor was developed using piezoresistive carbon loaded polyolefin film as the sensing element. The sensor design as well as its manufacturing is described in detail. The performance parameters of the sensor such as hysteresis, accuracy, and sensitivity were investigated experimentally. The sensor exhibited a bilinear pressure-sensitivity curve with a sensitivity values of 0.1 kPa-1 at a lower range of pressure (<10 kPa) and 0.025 kPa-1 in a higher pressure range (>10 kPa). The sensor displayed an average overall accuracy of about 88% and hysteresis of 13% at 5 kPa. The results obtained from the proposed pressure sensor configuration demonstrate that it can be successfully used for the development of flexible textile-based low-pressure sensors for biomedical and other similar applications. © 2016, Binary Information Press. All rights reserved.


Parmar S.,RMIT University | Parmar S.,Wound Management Innovation Cooperative Research Center | Bafekrpour E.,RMIT University | Bafekrpour E.,Wound Management Innovation Cooperative Research Center | And 4 more authors.
Textile Bioengineering and Informatics Symposium Proceedings 2016 - 9th Textile Bioengineering and Informatics Symposium, TBIS 2016, in conjunction with the 6th Asian Protective Clothing Conference, APCC 2016 | Year: 2016

In present research, pressure sensors based on piezoresistive films for integration in smart medical textiles are evaluated using rigid electrodes forming rigid experimental pressure sensors. A systematic study was carried out to investigate the effect of sensing area and number of layers of piezoresistive films on experimental pressure sensor's performance parameters such as pressure sensitivity, hysteresis, and accuracy of output. At 10 kPa pressure, these experimental pressure sensors with a sensing area of 100 mm2 demonstrated pressure sensitivity of 0.05 kPa-1. The pressure sensitivity of sensors increased with an increase in sensing area and with the number of layers of the piezoresistive film. Hysteresis remained in a range of 23% to 25% and demonstrated negligible variations with change in sensing area from 100 mm2 to 900 mm2. The accuracy of all the sensors was found to be above 80%, however no pronounced corelation between the sensing area and the number of layers of the piezoresistive film was observed. It was found that the piezoresistive sensing film can be sucessfully used to fabricate a pressure sensor operating in low-pressure range below 50 kPa. © 2016, Binary Information Press. All rights reserved.


Burgess J.D.,University of Queensland | Burgess J.D.,Wound Management Innovation Cooperative Research Center | Cameron C.M.,Griffith University | Watt K.,James Cook University | Kimble R.M.,University of Queensland
Trials | Year: 2016

Background: Globally, burns are the fifth leading cause of non-fatal children's injuries, and the leading cause of childhood burns is hot beverage scalds. Although there have been a number of programmes aimed at preventing scalds in children, very few have specifically addressed hot beverage scalds, and fewer have reported a reduction in injury rates. In Australia, hot beverage scalds account for 18 % of all childhood burns - a figure that has remained constant for the past decade. Innovative new technologies, such as Smartphone applications (apps), present a novel way for delivering individual-level injury prevention messages. The low cost, scalability and broad reach make this technology an ideal channel for health interventions. One of the latest methods being used in health-related apps aimed at behaviour change is gamification. Gamification uses the gaming principles of rewards, competition and personalisation to engage participants and motivate them towards preferred behaviours. This intervention will use a Smartphone app-based platform that combines gamification and behaviour-change strategies to increase knowledge and awareness of hot beverage scald risks and burn first aid among mothers of young children. Methods/design: This is a two-group, parallel, single-blinded randomised control trial (RCT) to evaluate the efficacy of a Smartphone app-based injury prevention intervention. The primary outcome measure is change in knowledge. Change in knowledge is measured in three components: knowledge of correct burns first aid; knowledge of the main cause of burns/scalds in children aged 0-15yrs; knowledge of the main age group at risk for burns/scalds. The secondary outcome measures relate to the gamification methods, measuring participants frequency of engagement with the Cool Runnings app. Queensland-based mothers aged 18+ years who own a Smartphone and have at least one child aged 5-12 months are eligible to participate. Discussion: To our knowledge, this is the first study to evaluate an app-based delivery of injury prevention messages, and the first study to test the efficacy of gamification techniques in an injury prevention intervention. If this intervention is found to be effective, this RCT will provide a platform for targeting other childhood injury prevention campaigns. Trial registration: This trial was registered on 14 January 2016 with the Australian New Zealand Clinical Trials Registry ( ACTRN12616000019404 ). © 2016 Burgess et al.


Szili E.J.,University of South Australia | Szili E.J.,Wound Management Innovation Cooperative Research Center | Oh J.-S.,Kochi University of Technology | Hong S.-H.,University of South Australia | And 4 more authors.
Journal of Physics D: Applied Physics | Year: 2015

We report a simple experimental approach to follow the transport of helium (He) plasma-generated reactive oxygen and nitrogen species (RONS) through millimetre thick agarose targets. These RONS may be either primary RONS, generated directly by the plasma jet, or secondary RONS generated for example at the surface of, or within, the material. Our experiment involves placing an agarose film over a quartz cuvette filled with deionized water. The agarose film is exposed to a He plasma jet and the UV absorption profile (of the deionized water) is recorded in real-time. Plasma exposure time, source-target distance and agarose film thickness and composition are varied to explore their effects on the depth of RONS delivery by the plasma jet. We conclude that plasma UV plays a minor role in the transport of RONS; whereas direct plasma contact and the He gas flow promote the transport of RONS into tissue. Our data indicate an accumulation of RONS within the agarose film (during plasma exposure) and a subsequent (time-lagged) release into the deionized water. Our approach can be readily adapted to other plasma sources; it can accommodate more complex biological materials, and has the potential to provide new insights into plasma-induced phenomena within real tissues. © 2015 IOP Publishing Ltd.


Oh J.-S.,Kochi University of Technology | Szili E.J.,University of South Australia | Szili E.J.,Wound Management Innovation Cooperative Research Center | Gaur N.,University of South Australia | And 7 more authors.
Journal of Photopolymer Science and Technology | Year: 2015

We demonstrated the efficacy of using a simple experimental approach, involving UV absorption spectroscopy, to monitor the transport of reactive oxygen and nitrogen species (RONS) through an agarose film (as surrogate for real tissue) into deionized (DI) water. The experiment involved placing a 4 mm thick agarose film over a quartz cuvette filled with DI water. The agarose film was exposed to a non-thermal, He atmospheric-pressure plasma jet (APPJ) and the UV absorption of the DI water was recorded in real-time. Our results indicate an accumulation of RONS within the agarose film during APPJ exposure and a subsequent time-lapsed release of RONS into the DI water. Curve fitting of the UV spectra suggested the APPJ transported and / or generated at least four RONS (NaNO2, HNO3, H2O2 and O2) through the 4 mm thick agarose film. Our approach of analyzing the delivery depth of RONS through synthetic tissue targets might find use in the future development of APPJ medical therapies and for improving our understanding of APPJ interactions with soft tissue. © 2015SPST.


PubMed | Wounds West Wound Healing Institute Australia, Queensland University of Technology, Bundall Medical Center, Silver Chain Group and 2 more.
Type: Journal Article | Journal: International wound journal | Year: 2016

Chronic wounds cost the Australian health system at least US$285 billion per year. Wound care services in Australia involve a complex mix of treatment options, health care sectors and funding mechanisms. It is clear that implementation of evidence-based wound care coincides with large health improvements and cost savings, yet the majority of Australians with chronic wounds do not receive evidence-based treatment. High initial treatment costs, inadequate reimbursement, poor financial incentives to invest in optimal care and limitations in clinical skills are major barriers to the adoption of evidence-based wound care. Enhanced education and appropriate financial incentives in primary care will improve uptake of evidence-based practice. Secondary-level wound specialty clinics to fill referral gaps in the community, boosted by appropriate credentialing, will improve access to specialist care. In order to secure funding for better services in a competitive environment, evidence of cost-effectiveness is required. Future effort to generate evidence on the cost-effectiveness of wound management interventions should provide evidence that decision makers find easy to interpret. If this happens, and it will require a large effort of health services research, it could be used to inform future policy and decision-making activities, reduce health care costs and improve patient outcomes.


PubMed | University of South Australia and Wound Management Innovation Cooperative Research Center
Type: Journal Article | Journal: Journal of natural products | Year: 2015

The purpose of this study was to assess the biofilm-removing efficacy and inflammatory activity of a serrulatane diterpenoid, 8-hydroxyserrulat-14-en-19-oic acid (1), isolated from the Australian medicinal plant Eremophila neglecta. Biofilm breakup activity of compound 1 on established Staphylococcus epidermidis and Staphylococcus aureus biofilms was compared to the antiseptic chlorhexidine and antibiotic levofloxacin. In a time-course study, 1 was deposited onto polypropylene mesh to mimic a wound dressing and tested for biofilm removal. The ex-vivo cytotoxicity and effect on lipopolysaccharide-induced pro-inflammatory cytokine release were studied in mouse primary bone-marrow-derived macrophage (BMDM) cells. Compound 1 was effective in dispersing 12 h pre-established biofilms with a 7 log10 reduction of viable bacterial cell counts, but was less active against 24 h biofilms (approximately 2 log10 reduction). Compound-loaded mesh showed dosage-dependent biofilm-removing capability. In addition, compound 1 displayed a significant inhibitory effect on tumor necrosis factor alpha (TNF-) and interleukin-6 (IL-6) secretion from BMDM cells, but interleukin-1 beta (IL-1) secretion was not significant. The compound was not cytotoxic to BMDM cells at concentrations effective in removing biofilm and lowering cytokine release. These findings highlight the potential of this serrulatane diterpenoid to be further developed for applications in wound management.


PubMed | University of Sheffield, University of South Australia and Wound Management Innovation Cooperative Research Center
Type: Journal Article | Journal: ACS applied materials & interfaces | Year: 2016

Skin has a remarkable capacity for regeneration; however, with an ever aging population, there is a growing burden to the healthcare system from chronic wounds. Novel therapies are required to address the problems associated with nonhealing chronic wounds. Novel wound dressings that can encourage increased reepithelialization could help to reduce the burden of chronic wounds. A suite of chemically defined surfaces have been produced using plasma polymerization, and the ability of these surfaces to support the growth of primary human skin cells has been assessed. Additionally, the ability of these surfaces to modulate cell migration and morphology has also been investigated. Keratinocytes and endothelial cells were extremely sensitive to surface chemistry showing increased viability and migration with an increased number of carboxylic acid functional groups. Fibroblasts proved to be more tolerant to changes in surface chemistry; however, these cells migrated fastest over amine-functionalized surfaces. The novel combination of comprehensive chemical characterization coupled with the focus on cell migration provides a unique insight into how a materials physicochemical properties affect cell migration.


PubMed | Healthcare Improvement Unit, Metro North Hospital & Health Service, Metro North Hospital and Health Service, Queensland University of Technology and Wound Management Innovation Cooperative Research Center
Type: | Journal: International wound journal | Year: 2016

In addition to affecting quality of life, diabetic foot ulcers (DFUs) impose an economic burden on both patients and the health system. This study developed a Markov model to analyse the cost-effectiveness of implementing optimal care in comparison with the continuation of usual care for diabetic patients at high risk of DFUs in the Australian setting. The model results demonstrated overall 5-year cost savings (AUD 910011 for those aged 35-54, $939160 for those aged 55-74 and $1239497 for those aged 75 or older) and improved health benefits measured in quality-adjusted life years (QALYs) (013 QALYs, 013 QALYs and 016 QALYs, respectively) for high-risk patients receiving optimal care for DFUs compared with usual care. Total cost savings for Australia were estimated at AUD 27 billion over 5 years. Probabilistic sensitivity analysis showed that optimal care always had a higher probability of costing less and generating more health benefits. This study provides important evidence to inform Australian policy decisions on the efficient use of health resources and supports the implementation of evidence-based optimal care in Australia. Furthermore, this information is of great importance for comparable developed countries that could reap similar benefits from investing in these well-known evidence-based strategies.

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