Inoue D.,Kyoto University |
Kimura I.,Kyoto University |
Wakabayashi M.,Kyoto University |
Tsumoto H.,World Leading Drug Discovery Research Center |
And 7 more authors.
FEBS Letters | Year: 2012
Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gβγ-PLCβ3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.