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Worcester, MA, United States

For other "Worcester Colleges," see Worcester College .Worcester State University's 58-acre campus is nestled in the residential northwest side of Worcester—the second largest city in New England—home to 35,000 college students at more than a dozen colleges and universities. Wikipedia.

Street C.A.,Worcester State University | Bryan B.A.,Texas Tech University Health Sciences Center
Anticancer Research | Year: 2011

Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that function as modulators of actin-myosin cytoskeletal dynamics via regulation of Lin11, Isl-1 & Mec-3 domain (LIM) kinase, myosin light chain (MLC), and MLC phosphatase. A strong correlation between cytoskeletal rearrangements and tumor cell invasion, metastasis, and deregulated microenvironment interaction has been reported in the literature, and the utilization of pharmacological inhibitors of ROCK signaling for the treatment of cancer is actively being pursued by a number of pharmaceutical companies. Indeed, in many preclinical models ROCK inhibitors have shown remarkable efficacy in reducing tumor growth and metastasis. Interestingly, ROCK signaling has been shown to be either pro-apoptotic or pro-survival in a cell type and context dependent manner, though the molecular mechanisms controlling ROCK-mediated cell fate decisions are unknown. This review summarizes the many pleiotropic roles of ROCK signaling in survival and apoptosis, and suggests that controlled modulation of ROCK activity in tumor cells has the potential to significantly affect tumor survival and patient outcome. Source

Chalupka S.,Worcester State University
AAOHN journal : official journal of the American Association of Occupational Health Nurses | Year: 2010

Bedbugs are increasingly encountered in hotels, motels, office buildings, movie theaters, and modes of transport--anywhere the turnover of occupants is constant. Copyright 2010, SLACK Incorporated. Source

Moynihan M.J.,Worcester State University
Workplace Health and Safety | Year: 2013

Wind technology jobs present uncertainties for worker health. More investigation is needed to ensure the safety of employees working on wind farms. Copyright © 2013 American Association of Occupational Health Nurses, Inc. Source

Mizock L.,Worcester State University | Russinova Z.,Boston University | Shani R.,Boston University
Qualitative Health Research | Year: 2014

People with serious mental illness face stigma that interferes with recovery. Photovoice is a method that integrates photography and writing, providing a valuable means for capturing the narratives of people with mental illness whose voices are often marginalized. The purpose of the present article is to explore the meaning of recovery for individuals with serious mental illness based on a qualitative analysis of a new photovoice-based intervention, Recovery Narrative Photovoice. This intervention focuses on promoting the process of recovery and sense of identity through the creation of empowering visual images and narratives of recovery for individuals with serious mental illness. In this article, we present iconographic and thematic analysis for the 23 photovoice works from two pilots of the Recovery Narrative Photovoice intervention. Results reveal several themes, including metaphors for mental illness, associated losses, recovery strategies, and recovery outcomes. A final theme pertains to recovery messages learned from the recovery process. © The Author(s) 2014. Source

Background: The relationship between object concept domains (living vs. nonliving) and their underlying feature structures is a frequent area of investigation regarding semantic processing in healthy individuals and some individuals with neuropsychological impairment resulting from herpes simplex encephalitis, semantic dementia, and Alzheimer's disease. However, this relationship has been less well investigated in persons with stroke-aphasia (PWA), even though many treatments for anomia following stroke are predicated on the use of semantic feature cues.Aims: As part of a larger investigation into the influence of semantic feature processing on naming for PWA, this study examined the ability of PWA to confirm the relations between object concepts and associated semantic features.Methods & Procedures: Fifteen native English-speaking, right-handed individuals with post-stroke-aphasia responded yes or no via button press to feature verification questions designed to probe the relationships between concept domain and feature type and distinctiveness.Outcomes & Results: PWA were more accurate and quicker to confirm concept-feature relationships when features contained function/action, rather than visual-perceptual information about concepts and when features were distinctive to concepts rather than shared. The truthfulness (i.e., veracity) of concept-feature pairings was demonstrated to differentially affect living versus nonliving concepts. Within domain, only nonliving concepts were verified more accurately and more quickly when pairings were true (rather than false). Between domains, true nonliving concept-feature pairings were more accurately and more quickly verified than true living concept-feature pairings. Also with respect to veracity, correlations were observed between aphasia severity and accuracy and speed of response to false concept-feature pairings.Conclusions: Findings have implications for the way in which semantic processing is probed with PWA, as well as providing preliminary information regarding responsivity of PWA to differing types of semantic information for living versus nonliving concepts. The fact that PWA demonstrated disproportionate difficulty responding to certain types of semantic information also suggests preliminary implications for the utility of different types of semantic cues in semantically based treatments for word retrieval impairment. © 2014 © 2014 Taylor & Francis. Source

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