Iksan, South Korea
Iksan, South Korea

Wonkwang University is a university located in Iksan, South Korea. Founded as Youilhakrim in 1946, it is one of the few academies affiliated with Won Buddhism. Yuilhakrim was succeeded by Wonkwang Junior College in 5 November 1951, and gained college status in 29 January 1953. The Postgraduate School was opened in 1967, and in 1971 it gained university status.The university is known for its diverse medical courses: western medicine, dentistry, pharmacy, traditional Korean medicine, and traditional Korean pharmacy. Beside medical courses, the school is well known for its specialised courses such as police administration, fire service administration, and law school.Wonkwang University is one of the two only schools in South Korea that have courses for antiques restoration. Wikipedia.


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Kim T.H.,Wonkwang University
World journal of gastroenterology : WJG | Year: 2012

To determine the utility of endoscopic ultrasound-guided biliary drainage (EUS-BD) with a fully covered self-expandable metal stent for managing malignant biliary stricture. We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered self-expandable metal stent when endoscopic retrograde cholangiopancreatography (ERCP) fails. EUS-guided choledochoduodenostomy (EUS-CD) and EUS-guided hepaticogastrostomy (EUS-HG) was performed in 9 patients and 4 patients, respectively. The technical and functional success rate was 92.3% (12/13) and 91.7% (11/12), respectively. Using an intrahepatic approach (EUS-HG, n = 4), there was mild peritonitis (n = 1) and migration of the metal stent to the stomach (n = 1). With an extrahepatic approach (EUS-CD, n = 10), there was pneumoperitoneum (n = 2), migration (n = 2), and mild peritonitis (n = 1). All patients were managed conservatively with antibiotics. During follow-up (range, 1-12 mo), there was re-intervention (4/13 cases, 30.7%) necessitated by stent migration (n = 2) and stent occlusion (n = 2). EUS-BD with a nitinol fully covered self-expandable metal stent may be a feasible and effective treatment option in patients with malignant biliary obstruction when ERCP fails.


Park K.,Wonkwang University
Expert Systems with Applications | Year: 2014

Researchers have studied the various index structures and query processing algorithms to support efficient spatial queries in wireless communication environments. However, most previous studies have focused on server-side methods. In a server-side method, the server executes queries from individual clients and then relays the results. In our proposed method, the server transmits an index called DGI (Distributed Grid Index), and the client examines the received index to process spatial queries. The proposed index structure and search algorithm support efficient spatial queries in a wireless broadcast environment, shortening query search times. © 2013 Elsevier Ltd. All rights reserved.


Kang O.H.,Wonkwang University
European review for medical and pharmacological sciences | Year: 2013

Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic syndromes and is characterized by the accumulation of hepatic triglycerides (TG), which result from an imbalance between uptake, synthesis, export, and oxidation of fatty acids. Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric, was found to prevent obesity and diabetes in mouse models. However, a hypolipidemic effect of curcumin in oleic acid- induced hepatocarcinoma cells has not been reported. In this study, we examined the effect of curcumin on reducing lipid accumulation in hepatic cells. Hepatocytes were treated with oleic acid (OA) containing with or without curcumin to observe the lipid accumulation by Oil Red O stain. We also tested the effects of curcumin on triglycerides (TG) and total cholesterol (TC) in HepG2 cells. Western blot and reverse transcription polymerase chain reaction (RT-PCR) was used to measure sterol regulatory element binding proteins-1 (SREBP-1), fatty acid synthase (FAS), peroxisome proliferator-activated receptor (PPAR)-α, and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) expression. Curcumin suppressed OA-induced lipid accumulation and TG and TC levels. Also, curcumin decreased hepatic lipogenesis such as SREBP-1, and FAS. Besides, we also found out the antioxidative effect of curcumin by increasing the expression of PPARα. Curcumin increased AMPK phosphorylation in hepatocytes. These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this report, we found curcumin exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be active in the prevention of fatty liver.


Cheong H.C.,Wonkwang University
The Korean journal of hepatology | Year: 2011

Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes. Encephalopathy associated with metronidazole administration occurs rarely and depends on the cumulative metronidazole dose, and most patients with this condition recover rapidly after discontinuation of therapy. Because metronidazole is metabolized in the liver and can be transported by the cerebrospinal fluid and cross the blood-brain barrier, it may induce encephalopathy even at a low cumulative dose in patients with hepatic dysfunction. We experienced a patient who showed ataxic gait and dysarthric speech after receiving metronidazole for the treatment of hepatic encephalopathy that was not controlled by the administration of lactulose. The patient was diagnosed as metronidazole-induced encephalopathy, and stopping drug administration resulted in a complete recovery from encephalopathy. This case shows that caution should be exercised when administering metronidazole because even a low dose can induce encephalopathy in patients with liver cirrhosis.


Ahn C.K.,Wonkwang University
Nonlinear Dynamics | Year: 2010

This paper proposes a new delay-dependent state estimator for Takagi-Sugeno (T-S) fuzzy delayed Hopfield neural networks. By employing a suitable Lyapunov-Krasovskii functional, a delay-dependent criterion is established to estimate the neuron states through available output measurements such that the dynamics of the estimation error is asymptotically stable. It is shown that the design of the proposed state estimator for such neural networks can be achieved by solving a linear matrix inequality (LMI), which can be easily facilitated by using some standard numerical packages. An illustrative example is given to demonstrate the effectiveness of the proposed state estimator. © Springer Science+Business Media B.V. 2010.


Ahn C.K.,Wonkwang University
Nonlinear Dynamics | Year: 2010

This paper proposes a new ℋ∞ weight learning law for switched Hopfield neural networks with time-delay under parametric uncertainty. For the first time, the ℋ∞ weight learning law is presented to not only guarantee the asymptotical stability of switched Hopfield neural networks, but also reduce the effect of external disturbance to an ℋ∞ norm constraint. An existence condition for the ℋ∞ weight learning law of switched Hopfield neural networks is expressed in terms of strict linear matrix inequality (LMI). Finally, a numerical example is provided to illustrate our results. © 2009 Springer Science+Business Media B.V.


Ahn C.K.,Wonkwang University
Nonlinear Dynamics | Year: 2010

In this paper, we propose a new output feedback ℋ∞ synchronization method for delayed chaotic neural networks with external disturbance. Based on Lyapunov-Krasovskii theory and linear matrix inequality (LMI) approach, the output feedback ℋ∞ synchronization controller is presented to not only guarantee stable synchronization, but also reduce the effect of external disturbance to an ℋ∞ norm constraint. The proposed controller can be obtained by solving the LMI problem. An illustrative example is given to demonstrate the effectiveness of the proposed method. Copyright © 2009 Springer Science+Business Media B.V.


Ahn C.K.,Wonkwang University
Nonlinear Dynamics | Year: 2010

In this paper, we propose a new H∞ synchronization strategy, called a fuzzy delayed output feedback H∞ synchronization (FDOFHS) strategy, for chaotic systems in the presence of external disturbance. Based on Lyapunov-Krasovskii theory, the T-S fuzzy model, and a delayed feedback control scheme, the FDOFHS controller can guarantee stable synchronization. Furthermore, this controller reduces the effect of external disturbance to an H∞ norm constraint. The proposed controller can be obtained by solving the linear matrix inequality (LMI) problem. A simulation study is presented to demonstrate the validity of the proposed FDOFHS approach. © 2009 Springer Science+Business Media B.V.


Nonalcoholic fatty liver disease (NAFLD) has recently been found to be a novel component of metabolic syndrome (MS), which is one of the leading causes of chronic liver disease. The serum alanine aminotransferase (ALT) and -glutamyltransferase (GGT) levels are suggested to affect liver fat accumulation and insulin resistance. We assessed the associations of serum ALT and GGT concentrations within the reference ranges with MS and NAFLD. In total, 1,069 subjects enrolled at the health promotion center of Wonkwang University Hospital were divided into 4 groups according to serum ALT and GGT concentrations levels within the reference ranges. We performed biochemical tests, including liver function tests and lipid profiles, and diagnosed fatty liver by ultrasonography. Associations of ALT and GGT concentrationgrading within the reference range with fatty liver and/or MS were investigated. The presence of MS, its components, and the number of metabolic abnormalities [except for high-density lipoprotein-cholesterol (HDL-C) and fasting blood glucose] increased with the ALT level, while the presence of MS, its components, and the number of metabolic abnormalities (except for HDL-C) increased with the GGT level. The odds ratios for fatty liver and MS increased with the ALT level (P0.001 and P=0.049, respectively) and the GGT level (P=0.044 and P=0.039, respectively). Serum ALT and GGT concentrations within the reference ranges correlated with the incidence of NAFLD and MS in a dose-dependent manner. There associations need to be confirmed in large, prospective studies.


Kang H.J.,Wonkwang University
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | Year: 2010

To describe an arthroscopic technique for complete removal of the synovium from the elbow joint and to investigate the clinical outcomes of arthroscopic synovectomy in patients with rheumatoid elbow. Arthroscopic synovectomy was performed on 26 rheumatoid elbows in 25 patients with radiographic changes of Larsen grade 3 or less. We performed total synovectomy of the elbow using multiple portals and by dividing the elbow into the anterior, posterior, and radiocapitellar compartments. At a mean follow-up of 33.9 months (range, 13 to 68 months), pain was evaluated with a visual analog scale and range of motion was measured. The Mayo Elbow Performance Score was used to assess total elbow function. Radiologic changes were determined according to the Larsen grading system. The mean visual analog scale score for pain decreased from 6.5 to 3.1, and the mean flexion arc increased from 98.1 degrees to 113.3 degrees after the operation. The mean Mayo Elbow Performance Score improved from 58.5 to 77.4 points. There were 2 excellent, 17 good, 4 fair, and 3 poor results. Radiologic assessment showed no change in 13 elbows, improvement in 6, and progression in 7. Clinically apparent synovitis recurred in 4 elbows, in which the result was considered unsuccessful. Arthroscopic synovectomy of the elbow by use of multiple portals is a technically feasible procedure. It can effectively relieve pain, increase range of motion, improve Mayo Elbow Performance Score, and delay radiologic progression in rheumatoid elbows, resulting in a high satisfaction rate, although recurrent synovitis occurs in some patients. Level IV, therapeutic case series. 2010 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

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