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Iksan, South Korea

Wonkwang University is a university located in Iksan, South Korea. Founded as Youilhakrim in 1946, it is one of the few academies affiliated with Won Buddhism. Yuilhakrim was succeeded by Wonkwang Junior College in 5 November 1951, and gained college status in 29 January 1953. The Postgraduate School was opened in 1967, and in 1971 it gained university status.The university is known for its diverse medical courses: western medicine, dentistry, pharmacy, traditional Korean medicine, and traditional Korean pharmacy. Beside medical courses, the school is well known for its specialised courses such as police administration, fire service administration, and law school.Wonkwang University is one of the two only schools in South Korea that have courses for antiques restoration. Wikipedia.

To determine the utility of endoscopic ultrasound-guided biliary drainage (EUS-BD) with a fully covered self-expandable metal stent for managing malignant biliary stricture. We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered self-expandable metal stent when endoscopic retrograde cholangiopancreatography (ERCP) fails. EUS-guided choledochoduodenostomy (EUS-CD) and EUS-guided hepaticogastrostomy (EUS-HG) was performed in 9 patients and 4 patients, respectively. The technical and functional success rate was 92.3% (12/13) and 91.7% (11/12), respectively. Using an intrahepatic approach (EUS-HG, n = 4), there was mild peritonitis (n = 1) and migration of the metal stent to the stomach (n = 1). With an extrahepatic approach (EUS-CD, n = 10), there was pneumoperitoneum (n = 2), migration (n = 2), and mild peritonitis (n = 1). All patients were managed conservatively with antibiotics. During follow-up (range, 1-12 mo), there was re-intervention (4/13 cases, 30.7%) necessitated by stent migration (n = 2) and stent occlusion (n = 2). EUS-BD with a nitinol fully covered self-expandable metal stent may be a feasible and effective treatment option in patients with malignant biliary obstruction when ERCP fails. Source

Park K.,Wonkwang University
Expert Systems with Applications

Researchers have studied the various index structures and query processing algorithms to support efficient spatial queries in wireless communication environments. However, most previous studies have focused on server-side methods. In a server-side method, the server executes queries from individual clients and then relays the results. In our proposed method, the server transmits an index called DGI (Distributed Grid Index), and the client examines the received index to process spatial queries. The proposed index structure and search algorithm support efficient spatial queries in a wireless broadcast environment, shortening query search times. © 2013 Elsevier Ltd. All rights reserved. Source

Kang O.H.,Wonkwang University
European review for medical and pharmacological sciences

Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic syndromes and is characterized by the accumulation of hepatic triglycerides (TG), which result from an imbalance between uptake, synthesis, export, and oxidation of fatty acids. Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric, was found to prevent obesity and diabetes in mouse models. However, a hypolipidemic effect of curcumin in oleic acid- induced hepatocarcinoma cells has not been reported. In this study, we examined the effect of curcumin on reducing lipid accumulation in hepatic cells. Hepatocytes were treated with oleic acid (OA) containing with or without curcumin to observe the lipid accumulation by Oil Red O stain. We also tested the effects of curcumin on triglycerides (TG) and total cholesterol (TC) in HepG2 cells. Western blot and reverse transcription polymerase chain reaction (RT-PCR) was used to measure sterol regulatory element binding proteins-1 (SREBP-1), fatty acid synthase (FAS), peroxisome proliferator-activated receptor (PPAR)-α, and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) expression. Curcumin suppressed OA-induced lipid accumulation and TG and TC levels. Also, curcumin decreased hepatic lipogenesis such as SREBP-1, and FAS. Besides, we also found out the antioxidative effect of curcumin by increasing the expression of PPARα. Curcumin increased AMPK phosphorylation in hepatocytes. These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this report, we found curcumin exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be active in the prevention of fatty liver. Source

Cheong H.C.,Wonkwang University
The Korean journal of hepatology

Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes. Encephalopathy associated with metronidazole administration occurs rarely and depends on the cumulative metronidazole dose, and most patients with this condition recover rapidly after discontinuation of therapy. Because metronidazole is metabolized in the liver and can be transported by the cerebrospinal fluid and cross the blood-brain barrier, it may induce encephalopathy even at a low cumulative dose in patients with hepatic dysfunction. We experienced a patient who showed ataxic gait and dysarthric speech after receiving metronidazole for the treatment of hepatic encephalopathy that was not controlled by the administration of lactulose. The patient was diagnosed as metronidazole-induced encephalopathy, and stopping drug administration resulted in a complete recovery from encephalopathy. This case shows that caution should be exercised when administering metronidazole because even a low dose can induce encephalopathy in patients with liver cirrhosis. Source

This paper proposes a new ℋ∞ weight learning law for switched Hopfield neural networks with time-delay under parametric uncertainty. For the first time, the ℋ∞ weight learning law is presented to not only guarantee the asymptotical stability of switched Hopfield neural networks, but also reduce the effect of external disturbance to an ℋ∞ norm constraint. An existence condition for the ℋ∞ weight learning law of switched Hopfield neural networks is expressed in terms of strict linear matrix inequality (LMI). Finally, a numerical example is provided to illustrate our results. © 2009 Springer Science+Business Media B.V. Source

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