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Nouri M.,Womens Reproductive Health Research Center | Aghadavod E.,Kashan University of Medical Sciences | Khani S.,Research Center for Pharmaceutical Nanotechnology | Jamilian M.,Arak University of Medical Sciences | And 4 more authors.
Clinical Endocrinology | Year: 2016

Background: Anti-Müllerian hormone (AMH) is one of the most reliable markers of ovarian reserve. There is evidence which suggests that BMI may be associated with gene expression of AMH, AMH type II receptor (AMHR-II) and androgen receptor (AR) in human granulosa cells (GC) in women with and without polycystic ovary syndrome (PCOS). Objective: To investigate the association between BMI and gene expression of AMH, AMHR-II and AR in human GC in women with and without PCOS. Design, Patients and Measurements: In a cross-sectional study, hormonal profiles were measured among 38 patients with PCOS and 38 subjects without PCOS aged 18–40. AMH, AMHR-II and AR mRNA levels were quantified in cumulus GC. Pearson correlation and multiple linear regressions were used to assess the relationships. Results: Quantitative RT-PCR demonstrated that AMH and AMHR-II expression were negatively correlated with BMI (r = −0·39, P < 0·001 for AMH and r = −0·49, P < 0·001 for AMHR-II), whereas AR expression was positively correlated with BMI (r = 0·46, P < 0·001). Conclusions: There is a negative association between AMH, AMHR-II expression and BMI, and a positive association between AR expression and BMI in the GC of PCOS and non-PCOS women. © 2016 John Wiley & Sons Ltd


PubMed | Kashan University of Medical Sciences, Arak University of Medical Sciences, Womens Reproductive Health Research Center, Tehran University of Medical Sciences and 2 more.
Type: Journal Article | Journal: Clinical endocrinology | Year: 2016

Anti-Mllerian hormone (AMH) is one of the most reliable markers of ovarian reserve. There is evidence which suggests that BMI may be associated with gene expression of AMH, AMH type II receptor (AMHR-II) and androgen receptor (AR) in human granulosa cells (GC) in women with and without polycystic ovary syndrome (PCOS).To investigate the association between BMI and gene expression of AMH, AMHR-II and AR in human GC in women with and without PCOS.In a cross-sectional study, hormonal profiles were measured among 38 patients with PCOS and 38 subjects without PCOS aged 18-40. AMH, AMHR-II and AR mRNA levels were quantified in cumulus GC. Pearson correlation and multiple linear regressions were used to assess the relationships.Quantitative RT-PCR demonstrated that AMH and AMHR-II expression were negatively correlated with BMI (r=-039, P<0001 for AMH and r=-049, P<0001 for AMHR-II), whereas AR expression was positively correlated with BMI (r=046, P<0001).There is a negative association between AMH, AMHR-II expression and BMI, and a positive association between AR expression and BMI in the GC of PCOS and non-PCOS women.


Abolghasem S.P.,Womens Reproductive Health Research Center | Bonyadi M.R.,Medicine Faculty and Drug Applied Research Center | Babaloo Z.,Medicine Faculty and Drug Applied Research Center | Porhasan A.,Tabriz University of Medical Sciences | And 6 more authors.
Iranian Journal of Immunology | Year: 2011

Background: Toxoplasmosis is well known as an important infection in pregnant women. Although many serologic methods are available, diagnosis of early Toxoplasmosis may be extremely difficult. Objective: To detect the Toxoplasma IgG antibodies developed at the early stage of infection in pregnant women. Methods: 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled in this study. Anti-toxoplasma IgG, IgM and IgG avidity were evaluated by ELISA method. Results: The patients were categorized into three groups as follows: Group A, 124 cases; IgG+, IgM+, 55.1%; group B, 99 cases; IgG+, IgM-, 44%; and group C, 2 cases; IgG -, IgM +, 0.9%. Fifty five percent of the pregnant women had positive IgG and IgM among which 7.1% had low avidity which revealed an active infection in the pregnant women. In the current study, 44% of pregnant women had positive IgG and negative IgM, all of which had high avidity, which is an indication that in our population the level of toxoplasmosis infection is high and most women have had contacts with this parasite before pregnancy. Conclusion: In this study, the low avidity test was 7.1% showing that the occurrence of toxoplasmosis infection is still a serious issue. Observation of 45.8% high avidity among group A suggests that either IgM has a high half-life or there is a false positive IgM as a result of rheumatologic disorders. Therefore, avidity test is important in predicting maternal toxoplasmosis which is of value in disease treatment.


Shobeiri M.J.,Womens Reproductive Health Research Center | Shobeiri M.J.,Tabriz University of Medical Sciences | Gharabaghi P.M.,Womens Reproductive Health Research Center | Gharabaghi P.M.,Tabriz University of Medical Sciences | And 4 more authors.
Pakistan Journal of Medical Sciences | Year: 2013

Objective: The aim of this study was to evaluate fertility-sparing therapy in young patients with endometrial carcinoma. Methodology: This prospective study was carried out on 8 patients with clinical and radio-graphic stage IA, well differentiated endometrioid adenocarcinoma of the endometrium in Alzahra hospital, Tabriz, Iran. Treatment comprised high-dose megestrol acetate. Dilatation and curettage was repeated every three months. Results: The mean age of the patients was 30 (SD,3.21) years (range 24-35). Of the 8 patients, 7 (87.5%) achieved complete response. The mean time to response was 6.5 months (range 3-9). Of the complete responders, 3 of 7(42.8%) had recurrence; one patient underwent immediate hysterectomy, and 2 were successfully treated with second-line therapy and both subsequently conceived. Conception occurred in 3 of 7 patients (42.8%), in two more than once, However successful pregnancy occurred only in two patients. One patient developed Concomitant ovarian adenocarcinoma. Conclusions: High dose progestin therapy can be an effective fertility-sparing treatment in young patients with well differentiated stage IA endometrial endometrioid cancer confined to endometrium. However, close follow up is required because of risks of conservative treatment.


Fardiazar Z.,Womens Reproductive Health Research Center | Sadeghi-Bazargani H.,Tabriz University of Medical Sciences | Mohammadi R.,Karolinska Institutet
International Journal of General Medicine | Year: 2012

Background: The aim of this study was to map out some epidemiological aspects of intentional and unintentional injuries among Iranian women of reproductive age using a national registry. Methods: Injury data were taken from a national-based injury surveillance system over the period 2000-2002. The study population comprised 31.5% of the population of Iran. Results: Of all the 307,064 domestic injuries reported during the years 2000-2002, about 152,600 cases (49.7%) involved women. About half of these women (76,474) were in the reproductive age group. The majority (42.7%) of injuries among women of reproductive age were burn wounds followed by lacerations in 32.6%. Eighty-five percent of suicide cases were poisonings, followed by 11% for suicides by burning. However, 45.2% of burn suicides were fatal, compared with a 0.89% fatality rate for poisonings. Of all female suicide victims, 1029 died, 174 victims became disabled, while the remainder improved or were undergoing therapy when reported. Conclusion: Injuries, especially burns, are a major public health problem for women of reproductive age. © 2012 Fardiazar et al, publisher and licensee Dove Medical Press Ltd.


PubMed | Womens Reproductive Health Research Center
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2015

Endometrial cancer is the fourth most common cancer among women in developed countries. Affected patients may benefit from systemic chemotherapy, alone or in combination with targeted therapies if the disease is clinically diagnosed prior to expansion and metastasis to other organs.The aim of this study was to evaluate the prognostic role of c-kit mutations and comparision with tumor type and grade in human uterine endometrial carcinomas.Seventy five patients with endometrial carcinoma and seventy five normal controls were studied for possible mutations in exon 17 of the c-kit gene using single strand conformational polymorphisms and sequencing.c-kit mutation in exon 17 appeared to be significantly different between endometrial carcinoma and normal endometrium. The pattern and frequency of the mutations was also shown to be different between tumors from different stages.

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