Kokanali M.K.,Womens Health Education and Research Hospital |
Guzel A.I.,Womens Health Education and Research Hospital |
Erkilinc S.,Womens Health Education and Research Hospital |
Tokmak A.,Womens Health Education and Research Hospital |
And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014
Purpose: To investigate the risk factors for appendiceal metastasis of epithelial ovarian cancer and compare indings with the previous studies. Materials and Methods: One hundred and thirty-four patients with epithelial ovarian cancer were assessed in this study. All of them had undergone a surgical procedure including appendectomy. Of these, 21 (15.7%) patients who had appendiceal metastasis were analyzed as the case group and the patients with no metastasis were the controls, compared according to stage, grade, histology of tumor, preoperative Ca125 levels, presence of ascites, peritoneal cytology, diameter and site of tumor considered as risk factors. Results: We found statistically signiicant differences between the groups in terms of stage, grade, right-sided tumor location, presence of ascites, diameter of tumor≥10 cm and positive peritoneal cytology (p<0.05). In the logistic regression model, stage, grade, presence of ascites, right-sided location and diameter of tumor were independent risk factors. ROC curve analysis showed that stage, grade and diameter of the tumor were discriminative factors for appendiceal metastasis. Conclusions: In epithelial ovarian cancer, stage, grade, presence of ascites, right-sided location and large tumor size have importance for estimation of risk of appendiceal metastasis. As we compare our indings with previous studies, there is no deinite recommendation for the risk factors of appendiceal metastasis in epithelial ovarian cancer and more studies are needed.