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Gao S.,Woman and Child Hospital of Hubei Province | Li H.,Woman and Child Hospital of Hubei Province | Zhou X.-Q.,Woman and Child Hospital of Hubei Province | You J.-B.,Woman and Child Hospital of Hubei Province | And 4 more authors.
Cellular and Molecular Biology | Year: 2015

Withaferin A (WFA) is an active compound from Withania somnifera and has been reported to exhibit a variety of pharmacological activities such as anti-inflammatory, immunomodulatory and anti-tumor properties. In the present study, we investigated the potential protective role of WFA on acute lung injury in neonatal rats induced by lipopolysaccharide (LPS). We found that WFA significantly attenuated the pathological changes of lungs induced by LPS injection. Administration with WFA obviously decreased pulmonary neutrophil infiltration accompanied with decreased MPO concentrations. WFA also reduced the expression of pro-inflammatory cytokines including MIP-2, TNF-α, IL-1β and IL-6. Meanwhile, the expression levels of anti-inflammatory mediators such as TGF-β1 and IL-10 were significantly increased following WFA administration. Moreover, WFA protected LPS-treated rats from oxidative damage via up-regulation of TBARS and H2O2 concentrations and down-regulation of ROS contents. Taken together, the present study demonstrated that WFA administration attenuated LPS-induced lung injury through inhibition of inflammatory responses and oxidative stress. © 2015. Source


Gao S.,Woman and Child Hospital of Hubei Province | Tu D.N.,Woman and Child Hospital of Hubei Province | Li H.,Woman and Child Hospital of Hubei Province | Cao X.,Woman and Child Hospital of Hubei Province | And 4 more authors.
Genetics and Molecular Research | Year: 2015

The purpose of this study was to evaluate the relationship between zinc and the growth and development of young children. The parents of 8102 young children were surveyed in person by a trained surveyor using structured questionnaires. The hair zinc concentration of the children was determined using an atomic absorption spectrophotometer. The height, weight, sitting height, and head circumference of the children were measured at follow-up visits. There was a positive correlation between hair zinc concentration and adaptive developmental quotient (ADQ; r = 0.3164, P = 0.0272) while no correlation was found between hair zinc concentration and body measurement Z scores or intelligence quotient (IQ). There was a strong positive correlation between hair zinc concentration and weight-for-age Z scores (r = 0.3618, P = 0.0416) and ADQ (r = 0.2761, P = 0.0387) in boys; there was no correlation between hair zinc concentration and body measurement Z scores, IQ, and ADQ in girls. In boys with normal hair zinc levels, ADQ was 9.58 (P = 0.0392), higher than in boys who had zinc-deficient hair. In girls with normal hair zinc levels, ADQ was 2.52 (P = 0.0296), lower than in girls with zinc-deficient hair. In conclusion, there is no significant correlation between hair zinc levels and IQ or Z scores for all body measurements in young children. © FUNPEC-RP. Source

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