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Buckley J.P.,University of Chester | Quinlivan R.M.,Institute of Neurology and National Hospital for Neurology and Neurosurgery | Sim J.,Keele University | Eston R.G.,University of South Australia | Short D.S.,The Wolfson Center for Inherited Neuromuscular Disease
Journal of Sports Sciences | Year: 2014

The aim of this study was to assess a 12-min self-paced walking test in patients with McArdle disease. Twenty patients (44.7 ±11 years; 11 female) performed the walking test where walking speed, distance walked, heart rate (HR) and perceived muscle pain (Borg CR10 scale) were measured. Median (interquartile range) distance walked was 890 m (470-935). From 1 to 6 min, median walking speed decreased (from 75.0 to 71.4 m{bullet operator}min-1) while muscle pain and %HR reserve increased (from 0.3 to 3.0 and 37% to 48%, respectively). From 7 to 12 min, walking speed increased to 74.2 m{bullet operator}min-1, muscle pain decreased to 1.6 and %HR reserve remained between 45% and 48%. To make relative comparisons, HR and muscle pain were divided by walking speed and expressed as ratios. These ratios rose significantly between 1 and 6 min (HR:walking speed P =.001 and pain:walking speed P <.001) and similarly decreased between 6 and 11 min (P =.002 and P =.001, respectively). Peak ratios of HR:walking speed and pain:walking speed were inversely correlated to distance walked: rs (HR) = -.82 (P <.0001) and rs (pain) = -.55 (P =.012). Largest peak ratios were found in patients who walked < 650 m. A 12-min walking test can be used to assess exercise capacity and detect the second wind in McArdle disease. © 2014 Taylor & Francis.

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