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Wiwanitkit V.,Wiwanitkit House
Journal of Medical Case Reports | Year: 2011

Emerging infectious diseases are an important problem in medicine. Case reports usually document episodes in the early emerging phase or in a small outbreak. Although the case report is considered weak evidence in medical literature, it is usually the first report when there is a new emerging infectious disease. There is no doubt that case reports can provide useful information for further case series, reviews and studies. This editorial focuses on the usefulness of the case report on emerging infectious disease to the medical society. Publication in this area is highly welcomed by the journal and can serve as a future point of reference. © 2011 Wiwanitkit; licensee BioMed Central Ltd. Source

Wiwanitkit V.,Wiwanitkit House
Indian Journal of Medical and Paediatric Oncology | Year: 2013

Background: Ovarian tumor is a cause of infertility in the fertile-aged women. Also, it can also turns into malignancy and causes deadly outcome. Screening for malignancy is an important management. Aims: The available screening methods that are widely used at present include CA-125 determination and the risk of malignancy index (RMX), which is a combined CA-125 with ultrasonography, determination. Materials and Methods: Here, the author tries to assess cost-effectiveness of both alternative in screening by basic medical economics technique. Statistics: Classical descriptive analysis was used for cost effectiveness calculation. Results: In this work, from the cost-effectiveness analysis, the CA-125 test is more cost-effectiveness than RMX. Conclusion: This reflects that the usage of additional ultrasonography test for increasing the diagnostic activity in screening for ovarian cyst in the fertile aged females in Thailand is still not appropriate. Source

Wiwanitkit V.,Wiwanitkit House
Expert Review of Anti-Infective Therapy | Year: 2010

Dengue fever is a common tropical infection. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock. In this brief article, I will summarize and discuss the diagnosis and treatment of this disease. For diagnosis of dengue, most tropical doctors make use of presumptive diagnosis; however, the definite diagnosis should be based on immunodiagnosis or viral study. Focusing on treatment, symptomatic and supportive treatment is the main therapeutic approach. The role of antiviral drugs in the treatment of dengue fever has been limited, but is currently widely studied. © 2010 Expert Reviews Ltd. Source

Wiwanitkit V.,Wiwanitkit House
Journal of Cancer Research and Therapeutics | Year: 2011

Background: Hepatitis C virus is a common virus affecting human health. High rates of hepatitis C virus infection can be seen in many developing countries. It is accepted that hepatitis C virus is an oncogenic virus that can lead to liver cancer. Some recent researches also mentioned the possibility of hepatitis C virus as a risk for renal cell carcinoma. Aims: In this article, the author assesses the cause-outcome relationship between hepatitis C virus infection and renal cell carcinoma using the bioinformatics network analysis technique. Materials and Methods: The author firstly tracked for the hepatitis C virus related protein and renal cell carcinoma related protein and further detected the common protein. Further, tracing of the biological process using ontology study of the identified proteins was done and finalized network of relationship was derived. Statistical Analysis Used: Bioinformatics technique. Results and Conclusions: According to this study, there is only one common protein. Based on this work, it can be concluded that there might be cause-outcome relationship between hepatitis C virus infection and renal cell carcinoma via NY-REN-54. The process might be through the disturbance of autophagic response due to ubiquitin-protein ligase-related mechanism. Source

Wiwanitkit V.,Wiwanitkit House
Annals of Indian Academy of Neurology | Year: 2013

Alzheimer's disease is a common kind of dementia. This disorder can be detected in all countries around the world. This neurological disorder affects millions of population and becomes an important concern in modern neurology. There are many researches on the pathogenesis of Alzheimer's disease. Although it has been determined for a long time, there is no clear-cut that this is a case with genetic disorder or not. A physiological genomics is a new application that is useful for track function to genes within the human genome and can be applied for answering the problem of underlying pathobiology of complex diseases. The physiogenomics can be helpful for study of systemic approach on the pathophysiology, and genomics might provide useful information to better understand the pathogenesis of Alzheimer's disease. The present advent in genomics technique makes it possible to trace for the underlying genomics of disease. In this work, physiological genomics analysis for Alzheimer's disease was performed. The standard published technique is used for assessment. According to this work, there are 20 identified physiogenomics relationship on several chromosomes. Considering the results, the HADH2 gene on chromosome X, APBA1 gene on chromosome 9, AGER gene on chromosome 6, GSK3B gene on chromosome 3, CDKHR1 gene on chromosome 17, APPBP1 gene on chromosome 16, APBA2 gene on chromosome 15, GAL gene on chromosome 11, and APLP2 gene on chromosome 11 have the highest physiogenomics score (9.26) while the CASP3 gene on chromosome 4 and the SNCA gene on chromosome 4 have the lowest physiogenomics score (7.44). The results from this study confirm that Alzheimer's disease has a polygenomic origin. © 2013 Annals of Indian Academy of Neurology. Source

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