Wits Advanced Drug Delivery Platform Research Unit

Parktown, South Africa

Wits Advanced Drug Delivery Platform Research Unit

Parktown, South Africa

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Ngwuluka N.C.,Wits Advanced Drug Delivery Platform Research Unit | Choonara Y.E.,Wits Advanced Drug Delivery Platform Research Unit | Kumar P.,Wits Advanced Drug Delivery Platform Research Unit | Du Toit L.C.,Wits Advanced Drug Delivery Platform Research Unit | And 2 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2015

This study was undertaken to synthesize an interpo-lyelectrolyte complex (IPEC) of polymethacrylate (E100) and sodium carboxymethylcellulose (NaCMC) to form a polymeric hydrogel material for application in specialized oral drug delivery of sensitive levodopa. Computational modeling was employed to proffer insight into the interactions between the polymers. In addition, the reactional profile of NaCMC and polymethacrylate was elucidated using molecular mechanics energy relationships (MMER) and molecular dynamics simulations (MDS) by exploring the spatial disposition of NaCMC and E100 with respect to each other. Computational modeling revealed that the formation of the IPEC was due to strong ionic associations, hydrogen bonding, and hydrophilic interactions. The computational results corroborated well with the experimental and the analytical data. © 2014 Wiley Periodicals, Inc.


Ngwuluka N.C.,Wits Advanced Drug Delivery Platform Research Unit | Choonara Y.E.,Wits Advanced Drug Delivery Platform Research Unit | Kumar P.,Wits Advanced Drug Delivery Platform Research Unit | Du Toit L.C.,Wits Advanced Drug Delivery Platform Research Unit | And 2 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2015

This study was undertaken in order to apply a synthesized interpolyelectrolyte complex (IPEC) of polymethacry-late and carboxymethylcellulose as a controlled release oral tablet matrix for the delivery of the model neuroactive drug levodopa. The IPEC (synthesized in Part I of this work) was characterized by techniques such as Fourier Transform InfraRed (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), Advanced DSC (ADSC), and Scanning Electron Microscopy (SEM). The tablet matrices were formulated and characterized for their drug delivery properties and in vitro drug release. FTIR confirmed the interaction between the two polymers. The IPEC composite generated tablet matrices with a hardness ranging from 19.152-27.590 N/mm and a matrix resilience ranging between 42 and 46%. An IPEC of polyme-thacrylate and carboxymethylcellulose was indeed an improvement on the inherent properties of the native polymers providing a biomaterial with the ability to release poorly soluble drugs such as levodopa at a constant rate over a prolonged period of time. © 2014 Wiley Periodicals, Inc.

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