Winthrop University, often referred to as Winthrop or WU and formerly known as Winthrop College, is a public, coeducational, liberal arts university located in Rock Hill, South Carolina, United States. Founded in 1886 by David Bancroft Johnson, who served as the superintendent of Columbia, South Carolina schools, received a $1,500 grant from Robert Charles Winthrop, a Boston philanthropist and chair of the Peabody Education Board. The school originally opened in Columbia to educate young women to teach in the public schools.Winthrop offers undergraduate and graduate degrees through five colleges and schools and has current enrollment of about 6,000 students. The 100-acre main academic and residential campus is located 25 miles southwest of Charlotte, North Carolina and 71 miles north of Columbia, South Carolina in Rock Hill. Fielding athletic teams known as Winthrop Eagles, the university participates in the National Collegiate Athletic Association at the Division I level as a member of Big South Conference. The athletic program is known for its success in basketball. The majority of Winthrop's students are from South Carolina, with out-of-state and foreign students accounting for 11% of undergraduate enrollment. The university offers a number of extracurricular activities to its students, including athletics, honor societies, clubs and student organizations, as well as fraternities and sororities. Alumni and former students have gone on to prominent careers in government, business, science, medicine, education, sports, and entertainment. Wikipedia.
Winthrop University and Microbion | Date: 2016-05-10
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
Niederman M.S.,Winthrop University
Clinical Infectious Diseases | Year: 2010
Quantitative cultures have been proposed as the most accurate way to both establish the presence of ventilatorassociated pneumonia (VAP) and define the etiologic pathogen. Although the clinical diagnosis of VAP has been much maligned, it may be very accurate, particularly if it is objectively defined by calculating the Clinical Pulmonary Infection Score and if the score incorporates a Gram stain of a lower respiratory tract sample. After the clinical diagnosis of VAP is made, a culture is needed to identify the etiologic pathogen, but this culture does not need to be quantitative or bronchoscopic. Quantitative culture-based diagnosis may not be more accurate than clinical diagnosis, and quantitative cultures have a number of methodologic limitations that can cause both false-positive and false-negative results. Finally, a number of studies have suggested that clinical management without quantitative cultures may be accurate and that outcomes, such as mortality and change in antibiotics to a focused regimen, are not improved by the use of quantitative cultures. In clinical trials, management using nonquantitative cultures of a tracheal aspirate specimen may be preferable. Reliance on quantitative cultures can complicate enrollment and will ensure that only a subset of patients with VAP is studied because of the relatively high false-negative rate of quantitative culture results, particularly among patients treated with antibiotics before samples are obtained. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Radin M.S.,Winthrop University
Journal of General Internal Medicine | Year: 2014
Since the beginning of clinical use in the 1970s, hemoglobin A1c (A1c) has become the standard tool for monitoring glycemic control in patients with diabetes. The role of the A1c test was broadened in 2010, when the American Diabetes Association added A1c as a diagnostic criterion for diabetes. Because of hemoglobin A1c's integral role in diagnosis and treatment, it is important to recognize clinical scenarios and interfering factors that yield false results. The purpose of this review is to describe the A1c measurement, outline clinical scenarios or factors that may yield false results, and describe alternative laboratory biomarkers. © 2013 Society of General Internal Medicine.
Aloia J.F.,Winthrop University
Journal of Clinical Endocrinology and Metabolism | Year: 2011
Context: The Institute of Medicine (IOM) report on dietary reference intakes (DRI) for vitamin D is reviewed, along with its implications. Evidence Acquisition: Evidence-based reviews were completed; the IOM committee conducted its own literature search, an open public workshop, and two open sessions, and maintained a public web site for stakeholder input. The consensus report of the 14 scientists on the committee was reviewed by a panel of experts. Evidence Synthesis: Only bone health could be used as an indicator for DRI development. Evidence for extraskeletal outcomes was inadequate, inconsistent, or insufficient to develop DRI. The recommended dietary allowance was found to be 600 IU/d for ages 1-70 yr, corresponding on average to a serum 25-hydroxyvitamin D (25OHD) level of at least 50 nmol/liter (20 ng/ml), and 800 IU/d for those older than 70 yr. Comparison with current levels of 25OHD in the National Health and Nutrition Examination Survey population survey revealed that the vitamin D intake in the United States and Canada is adequate. An upper limit was set at 4000 IU/d for adults, corresponding to an average serum 25OHD level of 125 nmol/liter (50 ng/ml). Conclusion: Previous reports of an epidemic of vitamin D deficiency in North America were based on an overestimation of adequacy. Population screening with serum 25OHD is therefore not warranted. Current laboratory reference ranges for serum 25OHD are overestimated and should be revised. Practice guidelines to treat disease should not be applied to the healthy American population where use of the DRI is appropriate. Copyright © 2011 by The Endocrine Society.
Agency: NSF | Branch: Continuing grant | Program: | Phase: SEDIMENTARY GEO & PALEOBIOLOGY | Award Amount: 12.69K | Year: 2016
RUI, Collaborative Research: A High resolution Paleontological, Ichnological, and Chemostratigraphic Study of Late Devonian Mass Extinctions
Diana Boyer, EAR-1348981, SUNY Oswego
Gordon Love, EAR-1348988, Univ. California, Riverside
The rock record preserves a detailed history of past events in life history, and understanding these events, particularly episodes of unusual biotic turnover, is of paramount importance, particularly in this time of our current diversity crises. There have been many large scale extinction events throughout geologic history, and despite extensive study, the Late Devonian mass extinction events in the Frasnian-Famennian still remain enigmatic in terms of a causal mechanism. Although numerous kill mechanisms have been proposed, marine anoxia is widely thought to be a major contributing factor, in part because of the pervasiveness of organic-rich black shale. This study will test for extensive anoxic and/or pervasive euxinic (sulfidic water column) conditions associated with several biotic turnover events preserved in a Laurentian basin. PIs will use an integrated paleontological, inorganic geochemical, and lipid biomarker approach performed at high spatial resolution to reconstruct secular changes in ancient microbial and metazoan source organism inputs, and marine redox structure in these ancient epeiric seaways. They will test for a correlation between the magnitude and timing of extinction events and patterns of oxygen and euxinic stress which prevailed.
The utility of combining paleontological and geochemical proxies to recognize bottom water oxygen levels on a fine-scale in black shale facies has been realized (Boyer et al., 2011), but not yet applied to understand the dynamics of major events in the history of life. The new light we are shedding on Late Devonian biospheric and environmental evolution in North America will inform and direct future work in biogeochemistry, paleontology/paleobiology, evolutionary biology, and ocean-atmosphere evolution. Central to this research is a unique bridging of organic and inorganic geochemical methods with paleontology within a broad field-based template to yield high-resolution bio- and chemostratigraphic records that span the Late Devonian mass extinction events and their aftermath. At the heart of this research proposal is the training and education of a group of talented graduate, undergraduate and K-12 school students in the geosciences at UCR and SUNY Oswego, many from underrepresented ethnic groups, through a combination of direct involvement in the research project or through a variety of outreach ventures.
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 1.05M | Year: 2015
There is a well-documented need for competent, confident, and committed STEM teachers to serve in high-need school districts. Through this Phase 2 Noyce project, the Winthrop Initiative for STEM Educators, WISE, will provide scholarship funds to produce thirty-two new teachers at the middle and high school level who will be licensed to teach mathematics, biology, chemistry, and/or general science in the State of South Carolina. Each of these new teachers will have a solid foundation in the content area through a bachelors degree in the chosen STEM field. The project will provide support through several undergraduate and graduate initial licensure pathways. WISE will also enhance the undergraduate experience for approximately forty-eight high-achieving STEM majors by providing an annual summer internship program (designed to encourage students to consider STEM education as a career) that will include authentic research in the area of study and service learning in high-need schools. York Technical College, a 2-year institution, will partner with Winthrop University in the recruitment, mentoring, and support of Noyce scholars. This Phase 2 project, funded by the National Science Foundations (NSF) Robert Noyce Teacher Scholarship Program will also conduct a longitudinal study to examine several aspects of their pre-service teacher education work.
WISE provides students who pursue majors in a STEM field three pathways for becoming a teacher. The first option is designed for undergraduate mathematics and biology majors who decide early to pursue teacher preparation. Scholarship support will be provided for the final two years of a STEM majors undergraduate program allowing for certification in mathematics, biology, and chemistry, with options to extend licensure for middle grades and general science. The second option is for post-baccalaureate STEM majors who take coursework to complete a Master of Arts in Teaching (MAT) program leading to initial teacher certification. Both a fast track (3-term option) and a more flexible program that typically requires four semesters of coursework are offered. The third option is designed to combine aspects of the undergraduate and graduate program. It allows students to start working in schools as an undergraduate and complete certification at the graduate level in year five. This new model provides flexibility for research, electives, and a balanced approach that allows for fieldwork incorporated over time. During the course of this project the investigating team will continue longitudinal data collection in order to identify effective models related to recruitment and retention of qualified STEM educators. Areas to be examined include: recruitment efforts; transition experiences for 2-year college transfer students; summer research experiences; persistence; influence of content specialists on dispositions and skills, and the infrastructure to support new STEM teachers in high-need schools. Ultimately, not only will WISE contribute thirty-two well-qualified STEM teachers to the professional workforce, but WISE has the potential to contribute research-supported best practices for the recruitment, development, and retention of highly qualified STEM teachers for high-need schools.
Agency: NSF | Branch: Standard Grant | Program: | Phase: SOCIOLOGY | Award Amount: 57.00K | Year: 2015
Why are some school districts able to sustain school desegregation while others are not? Although social scientists have been active in studying the effects of school racial composition on student achievement, relatively neglected is the inclusion of variation among districts in the social factors that lead to school district segregation itself. Using five case studies and public opinion polls, the research team will study the relationship between citizen characteristics and their attitudes and values supporting (or failing to support) school desegregation. This study increases the value of five strategically chosen case studies including those of Wake County, NC (Raleigh); Davidson County, TN (Nashville); Jefferson County, KY (Louisville); Charlotte-Mecklenburg, NC and Rock Hill, SC by fielding an opinion poll in each location, where the polls contain mostly common questions across sites. These polls will reveal similarities and differences in adult attitudes that track to differences in how long these districts have sustained desegregated schools. Study findings have implications for other school districts beyond the five studied here in terms of formulating policy that will better support socioeconomic mixing of students, which enhances diversity by promoting educational attainment and upward mobility in society, especially for at-risk students.
Some school districts sustain desegregation over many years while others do not. Existing research is largely based on case studies. Case studies have limited external validity and are often heterogeneous in approach because researchers frame questions and invoke theory differently. The data obtained from in-depth interviews, participant observation, and document analyses are rarely triangulated with data from theoretically-driven surveys of the school districts adult population. These attitudes and values play an important part in explaining districts current school assignment policies and inform future policies as well. This study addresses gaps in existing social science literature on desegregation by using a common theoretical perspective and fielding a largely common questionnaire via Interactive Voice Response, supplemented by cell phone samples, across five school districts. The research will produce poll data on a minimum of 5000 adult respondents. Analysis will (1) embed each poll within the existing qualitative data on each case; and (2) use the poll data to analyze both commonalities and differences in values and attitudes across sites.
Agency: NSF | Branch: Standard Grant | Program: | Phase: WORKFORCE IN THE MATHEMAT SCI | Award Amount: 256.44K | Year: 2014
Winthrop University hosts a nine week research program, Winthrop University REU: Bridging Applied and Theoretical Mathematics. Research themes include differential equations modeling of cancer biology and the study of phylogenetics using algebraic geometry and combinatorics. A professional development seminar and a colloquium series supplement the faculty mentored research activities.
This program supports students from groups traditionally underrepresented in mathematics graduate programs, but welcomes all students from institutions whose highest mathematics degree is Bachelors degree. This project builds a diverse and talented group of mathematics students and supports their transition into graduate programs in STEM fields. In this project, faculty mentors provide sustained mentorship beyond the completion of the nine week research experience and participants are supported to present their findings at national meetings.
Winthrop University | Date: 2015-12-11
A method for measuring blood levels of DNA that is released upon death from specialized cells in the body, by using PCR or a quantitative probe technology to detect amplified methylated and demethylated forms of cell-specific gene DNA, representing normal tissue and cell specific origin, respectively. Using probes permits the sensitive and specific identification of demethylated cell-specific DNA patterns that are present only in the dying cells. The method offers a bioassay for detecting cell loss in diabetes based on circulating demethylated insulin gene DNA, and circulating demethylated myelin oligodendrocyte protein (MOG) genes of oligodendrocytes in multiple sclerosis, for example, and may be useful for screening, monitoring of disease progression, and selection and monitoring of therapies.
Winthrop University | Date: 2015-09-03
A method for measuring blood levels of cell DNA that is released upon cell death by using a quantitative probe technology to detect amplified methylated and demethylated forms of the insulin gene DNA, representing normal tissue and cell specific origin, respectively. Using probes permits the sensitive and specific identification of demethylated insulin DNA patterns that are present only in cells. The method offers a bioassay for detecting cell loss in diabetes, useful for screening of prediabetes, monitoring of disease progression, and selection and monitoring of therapies. The technique finds potential use in both Type I and Type II diabetes, as well as gestational diabetes.