Chambersburg, PA, United States
Chambersburg, PA, United States

Wilson College, founded 1869, is a private, Presbyterian-related, liberal arts college located on a 300-acre campus in Chambersburg, Pennsylvania, United States. It was founded by two Presbyterian ministers, but named for its first major donor, Sarah Wilson of nearby St. Thomas Township, Pennsylvania. For 144 years, Wilson has been a women's college. In 2013 the college's board of trustees voted to make the college coeducational beginning in the 2013-2014 academic year. Wilson College has about 700 students from 21 U.S. states and nine foreign countries. It's known for its Women with Children program, which allows single mothers to bring their children to live with them on campus, as well as for its veterinary medical technician and equestrian programs, and the Fulton Center for Sustainable Living, which operates a 7-acre organic farm and a CSA program that supplies community families and others with fresh, organic produce. Wikipedia.


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Krakauer T.,Integrated Toxicology Division | Stiles B.G.,Wilson College
Virulence | Year: 2013

Staphylococcus aureus plays an important role in numerous human cases of food poisoning, soft tissue, and bone infections, as well as potentially lethal toxic shock. This common bacterium synthesizes various virulence factors that include staphylococcal enterotoxins (SEs). These protein toxins bind directly to major histocompatibility complex class II on antigen-presenting cells and specific Vβ regions of T-cell receptors, resulting in potentially life-threatening stimulation of the immune system. Picomolar concentrations of SEs ultimately elicit proinflammatory cytokines that can induce fever, hypotension, multi-organ failure, and lethal shock. Various in vitro and in vivo models have provided important tools for studying the biological effects of, as well as potential vaccines/therapeutics against, the SEs. This review succinctly presents known physical and biological properties of the SEs, including various intervention strategies. In particular, SEB will often be portrayed as per biodefense concerns dating back to the 1960s.


News Article | October 28, 2016
Site: www.prweb.com

After the success of previous Pokemon maps, the Franklin County Visitors Bureau is releasing four new Pokemon maps to cover more of the sights of Franklin County. These new maps include one that covers three of the local colleges, Penn State University Mont Alto, Wilson College and Shippensburg University. The second map includes two of Franklin County’s special green spaces; Norlo Park and Caledonia State Park. The third includes downtown Mercersburg, Fort Loudoun and St Thomas and the last, downtown Greencastle. These exclusive maps highlight stops in the downtown area and take visitors on a journey across beautiful Franklin County. More information and destinations in those areas are also available for those wishing to extend their visit. Trainers are welcome to come into the Visitors Bureau at 37 South Main Street, Suite 100, to get their own copy of the map during office hours 8am-4:30pm Monday through Friday or the map can be downloaded online at https://issuu.com/fcvb/docs/college_pokemap, https://issuu.com/fcvb/docs/mercersburg_fort_loudoun_st_thomas_, https://issuu.com/fcvb/docs/norlo_park_and_caledonia_map and https://issuu.com/fcvb/docs/greencastle_map. Previous Pokemon Maps that the Visitors Bureau has created include Downtown Chambersburg and Waynesboro. The Franklin County Visitors Bureau invites all to explore Franklin County PA and enjoy the trails of history, arts, and architecture, recreation, natural beauty, fresh foods and the warm hospitality of communities like Chambersburg, Greencastle, Mercersburg, Shippensburg, and Waynesboro. Franklin County PA is located just north of the Mason Dixon Line and is an easy drive to Washington DC, Philadelphia, and Pittsburgh. Discover more…plan a visit soon at ExploreFranklinCountyPA.com or by contacting 866.646.8060.


Aruna K.,Wilson College | Mobashshera T.,Wilson College
EXCLI Journal | Year: 2012

β-lactams are the most widely used group of antimicrobials. However, increasing resistance to these valuable drugs in uropathogens, mediated principally by β-lactamases, has become a major concern. The present study was undertaken to determine the prevalence of Extended Spectrum β-Lactamase (ESBL) producers in clinical isolates of urine specimens, collected from various healthcare centres across south Mumbai. A total of 195 gram negative urine isolates were identified as Pseudomonas aeruginosa (13), Proteus mirabilis (21), Klebsiella pneumoniae (29), Escherichia coli (96), Enterobacter aerogenes (1), Enterobacter cloacae (1), Enterococcus fecalis (1), Morganella morganii (1), Citrobacter diversus (16), Citrobacter amalonaticus (5) and Proteus vulgaris (11). Antimicrobial Susceptibility Testing (AST) by Kirby-Bauer method showed 43.07 % (84/195) of the isolates were resistant to more than 70 % of the antibiotics used. Confirmatory screening using a combination of Double Disk Synergy Test (DDST), Phenotypic Confirmatory Disc Diffusion Test (PCDDT) and E-test revealed the overall prevalence of ESBL producers to be 34.71 % (68/195). The study showed 72.05 % of the ESBL producers to be resistant to fluoroquinolones, highlighting its extensive use in the region of south Mumbai. All ESBL producers were found to be sensitive to Imipenem whereas 82.36 % showed susceptibility to Amikacin making these 2 antibiotics the most effective choice of drug against ESBLs. In order to ensure rational treatment of highly resistant pathogens, the occurrence of ESBL and its primary studies may serve as a base for further research and findings.


Massey D.,St Johns College | Kulshrestha A.,St Johns College | Masih J.,St Johns College | Masih J.,Wilson College | And 2 more authors.
Building and Environment | Year: 2012

This study presents data on the size characterization concentration of PM10, PM5.0, PM2.5 and PM1.0. These particulate concentrations were monitored from October-07 to March-09 indoors and outdoors of five roadside and five urban homes using Grimm aerosol spectrometer in Agra, India. Annual average concentrations of coarse particles (PM10) indoor and outdoor were 247μgm-3 and 255μgm-3 at roadside houses and 181μgm-3 and 195μgm-3 at urban houses. PM5.0 concentrations at roadside houses were 211μgm-3 and 230μgm-3 and at urban houses were 145μgm-3 and 159μgm-3. For fine particles (PM2.5) the annual mean concentrations were 161μgm-3 and 160μgm-3 at roadside houses and 109μgm-3 and 123μgm-3 at urban houses. PM1.0 concentrations at roadside houses were 111μgm-3 and 112μgm-3 while at urban houses they were 99μgm-3 and 104μgm-3. Monthly and seasonal variations of coarse and fine particulate matter have been studied at both the monitoring sites. Significant seasonal variations of particulate pollutants were obtained using the daily average particulate concentrations along with the inter particulate ratios. Particulate indoor/outdoor ratios and concentrations were also linked with meteorological conditions and indoor activities using occupant's diary entries. The concentration of all sizes of particulate matter was found to be highest in winter season due to increase human activities and more space heating in indoors and due to low windspeed and high humidity in outdoors in comparison with other seasons. There was a strong correlation between indoor and outdoor particulate at both the sites. Health problems in occupants of the houses with higher concentrations of the fine particulate matter were more prominent. Household activities like cooking on stoves, indoor smoking and outdoor vehicular traffic, and garbage burning were found to be the major sources of particulate emissions indoor as well as outdoors. © 2011 Elsevier Ltd.


Weinstein S.A.,Womens and Childrens Hospital | Stiles B.G.,U.S. Army | Stiles B.G.,Wilson College
Expert Review of Anti-Infective Therapy | Year: 2012

Mycoplasma genitalium is a globally important sexually transmitted pathogen. Men infected with M. genitalium frequently present with dysuria, while women may present with or without urogenital symptoms. In some populations, M. genitalium is significantly associated with HIV-1 infection, and is also an etiological agent in pelvic inflammatory disease. However, there is insufficient evidence to establish a causative role of the organism in obstetric complications, including tubal factor infertility. Although several nucleic acid amplification tests offer rapid, sensitive methods for detecting M. genitalium, there is no standardized assay. Available evidence supports treatment of M. genitalium infections with an extended regimen of azithromycin and resistant strains respond to moxifloxacin. Accumulating evidence indicates growing fluoroquinolone resistance, including against moxifloxacin, emphasizing the need for new therapeutic strategies to treat M. genitalium infections. © 2012 Expert Reviews Ltd.


Weinstein S.A.,Womens and Childrens Hospital | Stiles B.G.,U.S. Army | Stiles B.G.,Wilson College
Sexual Health | Year: 2011

Mycoplasma genitalium is attracting increasing recognition as an important sexually transmitted pathogen. Presented is a review of the epidemiology, detection, presentation and management of M. genitalium infection. Accumulating evidence suggests that M. genitalium is an important cause of non-gonococcal, non-chlamydial urethritis and cervicitis, and is linked with pelvic inflammatory disease and, possibly, obstetric complications. Although there is no standard detection assay, several nucleic acid amplification tests have >95% sensitivity and specificity for M. genitalium. To date, there is a general lack of established protocols for screening in public health clinics. Patients with urethritis or cervicitis should be screened for M. genitalium and some asymptomatic sub-groups should be screened depending on individual factors and local prevalence. Investigations estimating M. genitalium geographic prevalence document generally low incidence, but some communities exhibit infection frequencies comparable to that of Chlamydia trachomatis. Accumulating evidence supports an extended regimen of azithromycin for treatment of M. genitalium infection, as data suggest that stat 1g azithromycin may be less effective. Although data are limited, azithromycin-resistant cases documented to date respond to an appropriate fluoroquinolone (e.g. moxifloxacin). Inconsistent clinical recognition of M. genitalium may result in treatment failure and subsequent persistence due to ineffective antibiotics. The contrasting nature of existing literature regarding risks of M. genitalium infection emphasises the need for further carefully controlled studies of this emerging pathogen. © 2011 CSIRO.


Majer J.M.,Wilson College | Komer A.C.,DePaul University | Jason L.A.,DePaul University
Journal of Dual Diagnosis | Year: 2015

Objective: The relationship between mental illness and human-immunodeficiency virus (HIV)-risk sexual behavior among persons with substance use disorders is not well-established because of differences in assessing psychiatric factors (types, symptoms, severity), substance use (diagnosis, survey responses, past substance use), and HIV-risk sexual behaviors (individual measures, combination of sex/drug use risk behaviors) across studies. This study utilized a more global and dimensional aspect of psychiatric issues (problem severity) to examine the relationship with HIV-risk sexual behaviors and substance use among persons with substance use disorders. Methods: Participants included 224 men and 46 women, with a mean age of 40.4 years (SD = 9.5). The most common substances were heroin/opiates, with 41.4% reporting use of these substances (n = 110), while 27.8% reported using cocaine (n = 74) and 12.8% reported using alcohol (n = 34). Of all participants, 39 (14.4%) were identified as having high psychiatric severity (defined using the psychiatric severity score from the Addiction Severity Index), which was used as an indication of probable comorbid psychiatric and substance use disorders. Among these participants likely to have comorbid disorders, hierarchical linear regression was conducted to examine HIV-risk sexual behaviors (number of partners and unprotected sexual behaviors in the past 30 days) in relation to psychiatric severity, substance use, and gender. Results: Gender (women) and psychiatric severity (higher) were significantly related to greater HIV-risk sexual behaviors. After entering gender and substance use into the regression model, psychiatric severity accounted for another 21.9% of the variance in number of partners and 14.1% of the variance in unprotected sexual behaviors. Overall, the models accounted for 55.5% and 15.6% of the variance, respectively. A significant interaction was found for number of partners (but not frequency of unprotected behavior), such that those higher in psychiatric severity and higher in substance use had a greater number of sexual partners. The model including this interaction term accounted for 63.4% of the variance in number of partners. Conclusions: Findings suggest psychiatric severity is an underlying risk factor for HIV-risk sexual behavior among persons with substance use disorders who have various psychiatric comorbidities. © 2015 Taylor & Francis Group, LLC.


Krakauer T.,U.S. Army | Stiles B.G.,Wilson College
Virulence | Year: 2013

Staphylococcus aureus plays an important role in numerous human cases of food poisoning, soft tissue and bone infections, as well as potentially lethal toxic shock. This common bacterium synthesizes various virulence factors that include staphylococcal enterotoxins (SEs). These protein toxins bind directly to major histocompatibility complex class II on antigen-presenting cells and specific Vβ regions of T-cell receptors, resulting in potentially life-threatening stimulation of the immune system. Picomolar concentrations of SEs ultimately elicit proinflammatory cytokines that can induce fever, hypotension, multi-organ failure, and lethal shock. Various in vitro and in vivo models have provided important tools for studying the biological effects of, as well as potential vaccines/therapeutics against, the SEs. This review succinctly presents known physical and biological properties of the SEs, including various intervention strategies. In particular, SEB will often be portrayed as per biodefense concerns dating back to the 1960s. © 2013 Landes Bioscience.


Masih A.,Analytical Research Laboratory | Masih J.,Wilson College | Taneja A.,Dr. M.G.R. Educational and Research Institute
Journal of Environmental Monitoring | Year: 2012

Soil is the major environmental reservoir of organic compounds and soil-air exchange is a key process in governing the environmental fate of these compounds on a regional and global scale. Samples of air and soil were collected to study the levels of PAHs in the air and soil of the Agra region. Concentrations of PAH measured at four locations in the city of Agra, covers industrial, residential, roadside and agricultural areas. Samples were extracted with hexane by ultrasonic agitation. Extracts were then fractioned on a silica-gel column and the aromatic fraction was analysed by GC-MS. The mean concentration of the total PAH (T-PAH) in the air of Agra was 24.95, 17.95 and 14.25 ng m -3, during winter, monsoon and summer respectively. The average concentration of T-PAH in the soil of Agra was 12.50, 8.25 and 6.44 μg g -1 in winter, monsoon and summer seasons respectively. The aim of this study was to investigate the rate of approach to equilibrium partitioning of PAHs between air and soil compartments and to determine the direction of net flux of the studied PAH between air and soil. Calculated soil-air fugacity quotients indicate that the soil may now be a source of some lighter weight PAHs to the atmosphere, whereas it appears to be still acting as a long-term sink for the heavier weight PAHs to some extent in this region. © 2012 The Royal Society of Chemistry.


Stiles B.G.,Wilson College | Barth G.,Wilson College | Barth H.,University of Ulm | Popoff M.R.,Institute Pasteur Paris
Toxins | Year: 2013

Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease of goats, sheep and cattle. Epsilon toxin (Etx) belongs to the aerolysin-like toxin family. It contains three distinct domains, is proteolytically-activated and forms oligomeric pores on cell surfaces via a lipid raft-associated protein(s). Vaccination controls Etx-induced disease in the field. However, therapeutic measures are currently lacking. This review initially introduces C. perfringens toxins, subsequently focusing upon the Etx and its biochemistry, disease characteristics in various animals that include laboratory models (in vitro and in vivo), and finally control mechanisms (vaccines and therapeutics). © 2013 by the authors; licensee MDPI, Basel, Switzerland.

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