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West Hattiesburg, MS, United States

William Carey University is a private Christian liberal arts college located in Hattiesburg, Mississippi in the United States, affiliated with the Southern Baptist Convention and the Mississippi Baptist Convention. The main campus is located in Hattiesburg, Mississippi, with a second campus located in the Tradition community near Gulfport, Mississippi and Biloxi, Mississippi. William Carey University was founded by W. I. Thames in 1892 as Pearl River Boarding School in Poplarville, Mississippi. A disastrous fire destroyed the school in 1905, and in 1906, with the backing of a group of New Orleans businessmen, Thames re-opened the school in Hattiesburg as South Mississippi College. Another fire destroyed the young institution, forcing it to close. In 1911, W. S. F. Tatum acquired the property and offered it as a gift to the Baptists, and the school re-opened as Mississippi Woman's College. In 1953, the Mississippi Baptist Convention voted to move the college into coeducational status, which necessitated a new name for the institution. In 1954, the board of trustees selected the name of William Carey College in honor of William Carey, the eighteenth century English cobbler-linguist whose decades of missionary activity in India earned him international recognition as the “Father of Modern Missions.” The school changed to university status in 2006.The college offers baccalaureate degrees in the areas of arts and letters, education, natural and behavioral science, business, religion, music, and nursing. The university also offers M.B.A, M.Ed., M.S. in psychology, M.S. in Health Information Systems, and an M.S.N. degree, as well as a specialist degree in elementary education and a Ph.D. in education administration. In 2009, William Carey opened the College of Osteopathic Medicine, and 2010, welcomed its first class of 110 students. In 2012, Carey added a Ph.D. program in nursing. Three trimesters of eleven weeks each comprise the academic year. Two summer sessions, a J-term, and a May Term session are also offered. Wikipedia.

Craig P.A.,Rochester Institute of Technology | Michel L.V.,Rochester Institute of Technology | Bateman R.C.,William Carey University
Biochemistry and Molecular Biology Education | Year: 2013

As biochemists, one of our most captivating teaching tools is the use of molecular visualization. It is a compelling medium that can be used to communicate structural information much more effectively with interactive animations than with static figures. We have conducted a survey to begin a systematic evaluation of the current classroom usage of molecular visualization. Participants (n = 116) were asked to complete 11 multiple choice and 3 open ended questions. To provide more depth to these results, interviews were conducted with 12 of the participants. Many common themes arose in the survey and the interviews: a shared passion for the use of molecular visualization in teaching, broad diversity in software preference, the lack of uniform standards for assessment, a desire for more quality resources, and the challenge of enabling students to incorporate visualization in their learning. The majority of respondents had used molecular visualization for more than 5 years and mentioned 32 different visualization tools used, with Jmol and PyMOL clearly standing out as the most frequently used programs at the present time. The most common uses of molecular visualization in teaching were lecture and lab illustrations, followed by exam questions, in-class or in-laboratory exercises, and student projects, which frequently included presentations. While a minority of instructors used a grading rubric/scoring matrix for assessment of student learning with molecular visualization, many expressed a desire for common use assessment tools. © 2013 by The International Union of Biochemistry and Molecular Biology.

Prasad R.,U.S. National Institutes of Health | Horton J.K.,U.S. National Institutes of Health | Chastain II P.D.,William Carey University | Gassman N.R.,U.S. National Institutes of Health | And 3 more authors.
Nucleic Acids Research | Year: 2014

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD+ and plays multifaceted roles in cellular responses to genotoxic stress, including DNA repair. It had been shown that mouse fibroblasts treated with a DNA methylating agent in combination with a PARP inhibitor exhibit higher cytotoxicity than cells treated with methylating agent alone. This lethality of the PARP inhibitor is dependent on apurinic/apyrimidinic (AP) sites in the DNA and the presence of PARP-1. Here, we show that purified PARP-1 is capable of forming a DNA-protein cross-link (DPC) by covalently attaching to the AP site. This DPC formation is specific to the presence of the natural AP site in DNA and is accompanied by a single-strand DNA incision. Cellular studies confirm the formation of PARP-1 DPCs during alkylating agent-induced base excision repair (BER) and formation of DPCs is enhanced by a PARP inhibitor. Using an N-terminal and C-terminal truncated PARP-1 we show that a polypeptide fragment comprising the zinc 3 and BRCT sub-domains is sufficient for DPC formation. The covalent attachment of PARP-1 to AP site-containing DNA appears to be a suicidal event when BER is overwhelmed or disrupted. © 2014 The Author(s) 2014.

Jarvis J.L.,Texas A&M University | McClure S.F.,Williamson County EMS | McClure S.F.,William Carey University | Johns D.,Williamson County EMS
Prehospital Emergency Care | Year: 2015

Introduction. Intubation success by paramedics has historically been variable. The lack of first-pass success (FPS) has been associated with increased adverse events. Various video laryngoscope (VL) devices have been investigated to improve success among paramedics. Conflicting research exists on VL vs. direct laryngoscopy (DL) by paramedics and on the effects of the specific King Vision device on FPS and overall success (OS) in an emergency medical services (EMS) system with low intubation frequency and historically low success rates. Objectives. To evaluate the effect of an ongoing training program using the King Vision VL on FPS, OS, and success per attempt when compared with DL in one suburban EMS system with low historical intubation success rates. Methods. We performed a retrospective analysis of electronic patient care reports in a suburban EMS system. We analyzed three metrics of intubation success before DL and after implementation of ongoing training with VL in both cardiac arrest and in all other indications: success per attempt, overall success, and first-pass success. We also performed an intention to treat analysis of these rates to account for protocol violations. Results. During the study period, intubation was attempted on 514 patients. There was no difference between the DL and VL groups in age, weight, gender, or percentage receiving paralytic medications. There was improvement over DL with VL in each of the outcome measures: overall success (64.9 vs. 91.5%, p < 0.01), first-pass success (43.8% vs. 74.2%, p < 0.01), and success per attempt (44.4 vs. 71.2%, p < 0.01). A subgroup analysis by indication for intubation also showed improvement in all metrics for all indications. There were several protocol violations: 11 of 376 attempts that should have used VL (2.9%) but were done with DL. An intention to treat analysis was therefore done. Again, we saw an improvement in all metrics for all indications.Conclusion. In this suburban EMS system with historically low intubation success rates and low frequency of intubation, paramedics were able to improve all measures of intubation success using the King Vision video laryngoscope and an ongoing training program when compared with direct laryngoscopy. © 2015 Taylor and Francis Group, LLC.

Adamson S.W.,University of Southern Mississippi | Browning R.E.,University of Southern Mississippi | Chao C.-C.,Naval Medical Research Center | Bateman R.C.,William Carey University | And 2 more authors.
Insect Biochemistry and Molecular Biology | Year: 2013

Glutaminyl cyclase (QC) catalyzes the cyclization of N-terminal glutamine residues into pyroglutamate. This post-translational modification extends the half-life of peptides and, in some cases, is essential in binding to their cognate receptor. Due to its potential role in the post-translational modification of tick neuropeptides, we report the molecular, biochemical and physiological characterization of salivary gland QC during the prolonged blood feeding of the black-legged tick (. Ixodes scapularis) and the gulf-coast tick (. Amblyomma maculatum). QC sequences from I.scapularis and A.maculatum showed a high degree of amino acid identity to each other and other arthropods and residues critical for zinc binding/catalysis (D159, E202, and H330) or intermediate stabilization (E201, W207, D248, D305, F325, and W329) are conserved. Analysis of QC transcriptional gene expression kinetics depicts an upregulation during the bloodmeal of adult female ticks prior to fast-feeding phases in both I.scapularis and A.maculatum suggesting a functional link with bloodmeal uptake. QC enzymatic activity was detected in saliva and extracts of tick salivary glands and midguts. Recombinant QC was shown to be catalytically active. Furthermore, knockdown of QC transcript by RNA interference resulted in lower enzymatic activity, and small, unviable egg masses in both studied tick species as well as lower engorged tick weights for I.scapularis. These results suggest that the post-translational modification of neurotransmitters and other bioactive peptides by QC is critical to oviposition and potentially other physiological processes. Moreover, these data suggest that tick-specific QC-modified neurotransmitters/hormones or other relevant parts of this system could potentially be used as novel physiological targets for tick control. © 2013 Elsevier Ltd.

Caleb Smith P.,William Carey University
Southeastern Geographer | Year: 2012

In recent years geographers have become increasingly interested in the idea of racialized landscapes. In the American South, this adds a new layer to some already heavily labeled places of racial identity and conflict. Although swimming pools are generally viewed by mainstream society as sites of recreation and socialization, this article conceptualizes them as racialized places on the landscape. Here, a group of swimming pools is studied over a period of time to analyze not just its history, but also its place within the social construct of race and racial politics in the United States. Through an analysis of Mississippi's public pools from 1900 to 2010, this article shows how racial identity and social change affected public pools and came to play a determining role in whether they declined or survived over time. This study contributes to current research on race and landscape by broadening the discussion to include public recreation spaces.

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