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Wheaton, IL, United States

Jones S.L.,Wheaton College at Illinois | Yarhouse M.A.,Regent University
Journal of Sex and Marital Therapy | Year: 2011

The authors conducted a quasi-experimental longitudinal study spanning 6-7 years examining attempted religiously mediated sexual orientation change from homosexual orientation to heterosexual orientation. An initial sample was formed of 72 men and 26 women who were involved in a variety of Christian ministries, with measures of sexual attraction, infatuation and fantasy, and composite measures of sexual orientation and psychological distress, administered longitudinally. Evidence from the study suggested that change of homosexual orientation appears possible for some and that psychological distress did not increase on average as a result of the involvement in the change process. The authors explore methodological limitations circumscribing generalizability of the findings and alternative explanations of the findings, such as sexual identity change or adjustment. Copyright © Taylor & Francis Group, LLC. Source


Harris W.S.,Cardiovascular Health Research Center | Thomas R.M.,Wheaton College at Illinois
Clinical Biochemistry | Year: 2010

Objectives: We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of 3 blood FA pools. Design and methods: We measured FA levels in red blood cells (RBCs), plasma and plasma phospholipids (PL) obtained from 20 healthy volunteers tested weekly over 6 weeks. Results: The within-subject coefficients of variation were 4.1% ± 1.9%, 15.9% ± 6.4%, and 14.5% ± 8.4%, respectively (RBC vs. others, p < 0.001). RBC omega-3 FA content had the lowest biological variability and was not altered in the fed state. Conclusions: From the perspective of variability and of the sample types tested, RBCs may be the preferred sample type for assessing omega-3 FA status. © 2009 The Canadian Society of Clinical Chemists. Source


Bishop R.C.,Wheaton College at Illinois
Interface Focus | Year: 2012

Complexity-nonlinear dynamics for my purposes in this essay-is rich with metaphysical and epistemological implications but is receiving sustained philosophical analysis only recently. I will explore some of the subtleties of causation and constraint in Rayleigh- Be ́nard convection as an example of a complex phenomenon, and extract some lessons for further philosophical reflection on top-down constraint and causation particularly with respect to causal foundationalism. © 2011 The Royal Society. Source


Bishop R.C.,Wheaton College at Illinois
Studies in History and Philosophy of Science Part B - Studies in History and Philosophy of Modern Physics | Year: 2010

Along with exploring some of the necessary conditions for the chemistry of our world given what we know about quantum mechanics, I will also discuss a different reductionist challenge than is usually considered in debates on the relationship of chemistry to physics. Contrary to popular belief, classical physics does not have a reductive relationship to quantum mechanics and some of the reasons why reduction fails between classical and quantum physics are the same as for why reduction fails between chemistry and quantum physics. However, a neoreductionist can accept that classical physics has some amount of autonomy from quantum mechanics, but still try to maintain that classical+quantum physics taken as a whole reduces chemistry to physics. I will explore some of the obstacles lying in the neoreductionist's path with respect to quantum chemistry and thereby hope to shed more light on the conditions necessary for the chemistry of our world. © 2009 Elsevier Ltd. Source


Francis S.H.,Vanderbilt University | Busch J.L.,Wheaton College at Illinois | Corbin J.D.,Vanderbilt University
Pharmacological Reviews | Year: 2010

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. cGMP binding activates PKG, which phosphorylates serines and threonines on many cellular proteins, frequently resulting in changes in activity or function, subcellular localization, or regulatory features. The proteins that are so modified by PKG commonly regulate calcium homeostasis, calcium sensitivity of cellular proteins, platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes. Current therapies that have successfully targeted the NO-signaling pathway include nitrovasodilators (nitroglycerin), PDE5 inhibitors [sildenafil (Viagra and Revatio), vardenafil (Levitra), and tadalafil (Cialis and Adcirca)] for treatment of a number of vascular diseases including angina pectoris, erectile dysfunction, and pulmonary hypertension; the PDE3 inhibitors [cilostazol (Pletal) and milrinone (Primacor)] are used for treatment of intermittent claudication and acute heart failure, respectively. Potential for use of these medications in the treatment of other maladies continues to emerge. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics. Source

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