Western New Mexico University is a public university located in Silver City, in the U.S. state of New Mexico. It has served the people of the state and its surrounding areas as a comprehensive, regional, rural, public coeducational university since 1893 and caters to a student body diverse in age, culture, language and ethnic background. Wikipedia.
Camacho Z.T.,Western New Mexico University |
Turner M.A.,Virology and Gene Therapy Program |
Barry M.A.,Mayo Medical School |
Weaver E.A.,Mayo Medical School
Human Gene Therapy | Year: 2014
The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. Low seroprevalent alternative viral vectors may be less impacted by preexisting immunity, but they may also have significantly different phenotypes from that of Ad5. In this study we compare species D Ads (26, 28, and 48) to the species C Ad5. In vitro transduction studies show striking differences between the species C and D viruses. Most notably, Ad26 transduced human dendritic cells much more effectively than Ad5. In vivo imaging studies showed strikingly different transgene expression profiles. The Ad5 virus was superior to the species D viruses in BALB/c mice when delivered intramuscularly. However, the inverse was true when the viruses were delivered mucosally via the intranasal epithelia. Intramuscular transduction was restored in mice that ubiquitously expressed human CD46, the primary receptor for species D viruses. We analyzed both species C and D Ads for their ability to induce prophylactic immunity against influenza in the CD46 transgenic mouse model. Surprisingly, the species D vaccines again failed to induce greater levels of protective immunity as compared with the species C Ad5 when delivered intramuscularly. However, the species D Ad vaccine vector, Ad48, induced significantly greater protection as compared with Ad5 when delivered mucosally via the intranasal route in CD46 transgenic mice. These data shed light on the complexities between the species and types of Ad. Our findings indicate that more research will be required to identify the mechanisms that play a key role in the induction of protective immunity induced by species D Ad vaccines. © 2014 Mary Ann Liebert, Inc.
Zuniga J.M.,Western New Mexico University |
Housh T.J.,University of Nebraska - Lincoln |
Camic C.L.,University of Wisconsin - Platteville |
Hendrix C.R.,University of Wisconsin-La Crosse |
And 4 more authors.
Journal of Strength and Conditioning Research | Year: 2012
The purpose of this study was to examine the effects of 7 days of supplementation with 20 g d -1 of creatine monohydrate (CM) on mean power (MP) and peak power (PP) from the Wingate anaerobic test (WAnT), body weight (BW), 1-repetition maximum (1RM) bilateral leg extension (LE) strength, and 1RM bench press (BP) strength. This study used a randomized, double-blind, placebo-controlled design. Twentytwo men (mean6SD: age = 22.1 ± 2.0 years; height = 178.0 ± 5.8 cm; body weight [BW] = 77.6 ± 7.6 kg) were randomly assigned to either a supplement (SUPP; n = 10) or placebo (PLAC; n = 12) group. The SUPP group ingested 20 g d -1 of CM powder for 7 days, whereas the PLAC ingested 20 g d -1 of maltodextrin powder. Measurements for the PLAC and SUPP groups included BW, PP, and MP from two 30-second Wants (separated by 7 minutes), and 1RM strength for LE and BP. Testing was conducted before (PRE) and after (POST) 7 days of ingesting either the supplement or placebo. The results of this study indicated that there was a significant (p ≤ 0.05) increase from PRE to POST testing in MP for the SUPP group (5.4%) but not for the PLAC group (20.3%). There were no between-group differences, however, for 1RM LE and 1RM BP strength. Furthermore, there were no changes in PP or BW for either group. The findings of this study indicated that loading with 20 g d -1of CM for 7 days increased MP (5.4%increase) from the WAnT, but it had no effect on strength (1RM LE and 1RM BP), PP, or BW. © 2012 National Strength and Conditioning Association.
Zakon H.H.,University of Texas |
Zakon H.H.,Bay Paul Center for Comparative and Molecular Biology |
Jost M.C.,Western New Mexico University |
Lu Y.,University of Texas
Molecular Biology and Evolution | Year: 2011
Mammals have ten voltage-dependent sodium (Nav) channel genes. Nav channels are expressed in different cell types with different subcellular distributions and are critical for many aspects of neuronal processing. The last common ancestor of teleosts and tetrapods had four Nav channel genes, presumably on four different chromosomes. In the lineage leading to mammals, a series of tandem duplications on two of these chromosomes more than doubled the number of Nav channel genes. It is unknown when these duplications occurred and whether they occurred against a backdrop of duplication of flanking genes on their chromosomes or as an expansion of ion channel genes in general. We estimated key dates of the Nav channel gene family expansion by phylogenetic analysis using teleost, elasmobranch, lungfish, amphibian, avian, lizard, and mammalian Nav channel sequences, as well as chromosomal synteny for tetrapod genes. We tested, and exclude, the null hypothesis that Nav channel genes reside in regions of chromosomes prone to duplication by demonstrating the lack of duplication or duplicate retention of surrounding genes. We also find no comparable expansion in other voltage-dependent ion channel gene families of tetrapods following the teleost-tetrapod divergence. We posit a specific expansion of the Nav channel gene family in the Devonian and Carboniferous periods when tetrapods evolved, diversified, and invaded the terrestrial habitat. During this time, the amniote forebrain evolved greater anatomical complexity and novel tactile sensory receptors appeared. The duplication of Nav channel genes allowed for greater regional specialization in Nav channel expression, variation in subcellular localization, and enhanced processing of somatosensory input. © 2010 The Author.
Kipp K.,University of Michigan |
Harris C.,Western New Mexico University |
Sabick M.B.,Boise State University
Journal of Strength and Conditioning Research | Year: 2011
The purpose of this study was to determine the effect of load on lower extremity biomechanics during the pull phase of the clean. Kinematic and kinetic data of the 3 joints of the lower extremity were collected while participants performed multiple sets of cleans at 3 percentages: 65, 75, and 85% of 1 repetition maximum (1RM). General linear models with repeated measures were used to assess the influence of load on angular velocities, net torques, powers, and rates of torque development at the ankle, knee, and hip joint. The results suggest that the biomechanical demands required from the lower extremities change with the lifted load and to an extent depend on the respective joint. Most notably, the hip and knee extended significantly faster than the ankle independent of load, whereas the hip and ankle generally produced significantly higher torques than the knee did. Torque, rate of torque development (RTD), and power were maximimal at 85% of 1RM for the ankle joint and at 75% of 1RM for the knee joint. Torque and RTD at the hip were maximal at loads >75% of 1RM. This study provides important novel information about the mechanical demands of a weightlifting exercise and should be heeded in the design of resistance training programs. © 2011 National Strength and Conditioning Association.
Agency: NSF | Branch: Standard Grant | Program: | Phase: ROBERT NOYCE SCHOLARSHIP PGM | Award Amount: 75.00K | Year: 2015
Western New Mexico University (WMNU) has received a Robert Noyce Teacher Scholarship Program Capacity Building grant to 1) develop and strengthen the teacher preparation network and pipeline from high school to college; 2) strengthen collaboration between the School of Education (SOE) and the STEM Departments at WNMU to more efficiently and effectively produce STEM teachers; and, 3) recruit high school and undergraduate students to consider STEM and STEM teaching careers through a focused effort to engage prospective STEM students in active teaching experiences early in their career. Through these activities, the PI team will build the critical capacity to effectively recruit high school and university students into the STEM teacher preparation program. Such a robust recruitment pathway will allow WMNU to have an impact on the national need to increase the number of STEM teachers and, in particular, to increase the number of Hispanic students who go into STEM teaching.
The WMNU PI team will develop an innovative workshop, the Mustang Science & Education Academy (MSEA), which will focus on developing collaborative relationships among the SOE, STEM departments and regional school districts. MSEA will also provide the needed active learning experiences for our students who express an interest in becoming STEM teachers. The project also is building connections to industry partners and regional educational agencies. These connections will help facilitate the recruitment, support, and induction of future STEM teachers. The evaluation of the project will provide an understanding of the effectiveness of the recruitment strategies that will inform the recruitment practices of teacher preparation programs across the country.