Vasile Goldis West University

Arad, Romania

Vasile Goldis West University

Arad, Romania
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Ionescu C.,Carol Davila University of Medicine and Pharmacy | Dimitriu M.,Carol Davila University of Medicine and Pharmacy | Poenaru E.,Carol Davila University of Medicine and Pharmacy | Viezuina R.,Sf Pantelimon Emergency Clinical Hospital | Furau C.G.,Vasile Goldis West University
Romanian Journal of Legal Medicine | Year: 2017

Consumption of noxious substances (alcohol, tobacco or drugs, even “the light” ones) is harmful during pregnancy. Nevertheless, in the contemporary Romania many pregnants do not drop out on these habits, on the contrary they even associate them. The goal of our study consists in the identification of these habits’ effects on the pregnancy and we carried on in the Department of Obstetrics-Gynecology “Sf. Pantelimon” Emergency Clinical Hospital Bucharest a prospective study based on the anonymous interviewing of 169 patients who got birth between March and April 2016. A number of 97 patients out of 169 patients declared that they referred to at least one out of three noxious habits (57.40%). Smoking is the best represented vice in the studied test sample, having a weight of 42.01% (71/169), followed by alcohol consumption - 30.17% (51/169) and by the associated consumption of alcohol and smoking - 15.38% (26/169). The least representative in the test sample was the drugs consumption, having a weight of 1.77% (3/169) but with an association of 100% with smoking (3/3 cases) and of 66.66% (2/3 cases) with alcohol consumption, fact that shows a great risk behaviour. Smoking associated with alcohol consumption, followed by smoking with no other associations had the negative effects on the average gestation age, average weight and average APGAR score. All categories of studied vices registered variable fetal somatic damages. © 2017 Romanian Society of Legal Medicine.

Sevastre B.,University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca | Sarpataki O.,University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca | Stan R.L.,University of Medicine and Pharmacy, Cluj-Napoca | Taulescu M.,University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca | And 8 more authors.
Farmacia | Year: 2017

Euonymus europaeus L. (Celastraceae) (EE), known as spindle tree, is a deciduous shrub commonly found all over European continent, used in traditional medicine for the treatment of ectoparasites. The present study investigates the in vitro anticancer effects of EE hydro-alcoholic extract prepared from fresh fruits. Qualitative and quantitative analysis of the EE extract content where made by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Cell Proliferation Assay and Anexin V-fluorescein isothiocyanate apoptosis detection where performed on both human melanoma cell line and normal human fibroblasts, in serial doses ranging from 0.05 µg/mL up to 50 µg/mL, at 6 and 24 hours exposure. Evodiamine, a potent anticancer compound was found in significant amounts. In vitro melanoma cells were inhibited in a concentration-dependent manner (p < 0.001), (IC50 = 6.76 µg/mL), and they were almost ten-fold more sensitive than fibroblasts (IC50 = 53.08 µg/mL). EE had a significant and selective antitumor activity. © 2017, Romanian Society for Pharmaceutical Sciences. All rights reserved.

Saplontai-Pop A.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan M.,Raluca Ripan Institute Of Chemistry | Oprean R.,University of Medicine and Pharmacy, Cluj-Napoca | Orasan O.,University of Medicine and Pharmacy, Cluj-Napoca | And 2 more authors.
Studia Universitatis Babes-Bolyai Chemia | Year: 2014

The present study aims to establish a correlation between the estimated thiosulfinate compound content of Allium cepa L. (A. cepa) juices and their antiplatelet activity. The juices were obtained from three different varieties of A. cepa, cultivated in three different regions of Romania.The thiosulfinate compound content was estimated using a spectrophotometric method, based on the reaction with 4-mercapto-pyridine (a chromogenic thiol, with a maximum absorbance coefficient at 324 nm). The constant of the reaction kinetic curve was obtained by overlapping experimental data with an exponential function of first degree.The antiplatelet activity of the mentioned juices was measured by using in vitro tests with platelet rich plasma (PRP) obtained from blood collected from healthy human people, with arachidonic acid as platelet agonist.A statistically significant direct proportionality between the estimated thiosulfinate compound content and the antiplatelet activity of the tested A.cepa juices was established. © 2014, Universitatea Babes-Bolyai, Catedra de Filosofie Sistematica. All rights reserved.

Muntean M.F.,Vasile Goldis West University | Vlase L.,University of Medicine and Pharmacy, Cluj-Napoca
Notulae Botanicae Horti Agrobotanici Cluj-Napoca | Year: 2011

The idea of studying the iridoids from the Melampyrum bihariense Kern has started from the few data found about the chemical composition of this species. The literature mentions the presence of iridoids found in two species of Melampyrum: Melampyrum arvense and Melampyrum cristatum. The study consists of a qualitative and quantitative analysis by modern chromatographic methods, TLC.TLC coupled with photo-densitometry as well as chromatography on the high performance column (LC/MS). The methanol extract was done from the flowers and leaves of Melamphyrum bihariense. For the TLC and HPLC, the aucubin was used as standard solution. The obtained chromatogram was examined in visible light spectrum, and then it was revealed with sulphuric anisaldehyde, emphasizing the brown coloured spots. In the TLC case, the chromatographic plate was scanned with a Shimadzu CS9000 photo densitometer after spraying with iron chloride, and for the HPLC the analytical column Atlantis HILIC was used 100 mm x 3.0 mm, 3.5 μm (water), and the ESI source of ions (electrospray ionisation). After the TLC analysis, the iridoids concentration found in the aucubin is 0.23 mg/mL in flowers and 0.24 mg/mL in leaves, and by the LC/MS method the concentration is of 1.8125 mg/ml in flowers and 2.3037 mg/ml in leaves.

Ciacli C.,Vasile Goldis West University
Romanian journal of internal medicine = Revue roumaine de médecine interne | Year: 2012

Determination of bone mineral density in patients with psoriatic arthritis and its correlation with the development of the disease. Three groups of patients were recruited: group 1--patients with psoriasis arthritis; group 2--patients with rheumatoid arthritis, group 3--control group. Group 1 was divided into: group 1A--patients with disease duration < 5 years and group 1B--patients with disease duration > 5 years. Bone mineral density was determined for total hip by dual X-ray absorptiometry (DXA). In the group 1A BMD values of total femur were between -1.32 and -1.68 DS; in the group 1B BMD values of total femur were between 1B -1.58 and - 1.77DS; in the group 2 BMD values of total femur were between -2.51 and -3.41 DS and in the control group BMD values of total femur were between 0.29 and 1.3 DS. In patients with psoriatic arthritis, the duration of arthritis was negatively correlated with BMD values of total femur. In conclusion, psoriatic patients with longer duration of disease may be at a risk for osteoporosis, which can require preventative treatment efforts.

Deme S.-M.,Vasile Goldis West University | Jianu D.C.,Victor Babes University of Medicine and Pharmacy Timisoara | Calomfirescu S.K.,University of Medicine and Pharmacy, Cluj-Napoca
Romanian Journal of Neurology/ Revista Romana de Neurologie | Year: 2011

Transverse myelitis may occur in isolation (idiopathic), or in the setting of another illness. Idiopathic transverse myelitis is assumed to be a result of abnormal activation of the immune system against the spinal cord. We report a 40-year-old woman with chronic urticaria and acute transverse myelitis associated with systemic lupus erythematosus. The urticaria appeared in her adolescence and after 26 years was followed by photosensitivity, peripheral polyarthritis and acute transverse myelitis, with positive antiphospholipid and antinuclear antibodies. Both chronic urticaria and acute transverse myelitis have been described associated appearing as the first manifestation of systemic lupus erythematosus. Transverse myelitis is a rare and still poorly understood condition reported in about 2% of patients with systemic lupus.

Hanganu D.,University of Medicine and Pharmacy, Cluj-Napoca | Vlase L.,University of Medicine and Pharmacy, Cluj-Napoca | Olah N.,Vasile Goldis West University
Notulae Botanicae Horti Agrobotanici Cluj-Napoca | Year: 2010

Phytoestrogens are natural compounds synthesized almost exclusively by plants of the Fabaceae family. To find new sources of phytoestrogens, we analyzed the isoflavons from different extracts obtained from plants of the Romanian spontaneous flora belonging to the Fabaceae family: Genistella sagittalis, Genista tinctoria, Cytisus albus, Coronilla varia, Lotus cornyculatus and Dorycnium herbaceum. The qualitative and quantitative analysis were performed by liquid chromatography coupled with mass spectrometry. The hydroalcoholic extracts were obtained by sonication for 10 minutes at 60°C. They were analyzed before and after hydrolysis. Some of the studied extracts presented a decreased level of isoflavons: Cytisus albus, Coronilla varia, Lotus cornyculatus and Dorycnium herbaceum. Other extracts were found to be rich in isoflavons. The high quantities of heterosides (daidzin, genistin, ononin) and aglycons (daidzein, genistein and formononetin) were found in Genistella sagittalis and Genista tinctoria. The results obtained for hydrolyzed extracts are inconclusive.

Ardelean A.,Vasile Goldis West University
Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii | Year: 2012

The study of the flora of the region, makes an inventory of the species of the plants found in the area of Lapus Country, analyzing the floristic composition also depending on the edafo-climatic main bioforms and geoelements factors. Floristic inventory of Lapus Country is carried out both on the searched area, and on the basis of summary data in the literature. The research carried out in the period 2006-2011, had as a purpose the inventory of flora in this region endeavouring at the presentation of a more complete picture of the flora and vegetation of this territory for broadening the horizon of knowledge of carpet plant in our country. ©2012 Vasile Goldis University Press.

Moldovan I.F.,Vasile Goldis West University
European Journal of Science and Theology | Year: 2014

The Church was closely linked to the feudal state and came to occupy a primordial position, becoming an integral part of the state mechanism and exercising its powers through its own governing bodies, including judiciary and military organs, given the large wealth and power it possessed. Trial proceedings in the ecclesiastical court and canonical litigations were no different from the usual proceedings. In what follows, we present a special form of trial, which resorted to an evidentiary means specific to that time: the wager of law.

PubMed | Vasile Goldis West University and Victor Babes University of Medicine and Pharmacy Timisoara
Type: Journal Article | Journal: Clujul medical (1957) | Year: 2015

The aim of this study is to evaluate the usefulness of the fecal immunochemical test (FIT) in colorectal cancer screening, detection of precancerous lesions and early colorectal cancer.The study evaluated asymptomatic patients with average risk (no personal or family antecedents of polyps or colorectal cancer), aged between 50 and 74 years. The presence of the occult haemorrhage was tested with the immunochemical faecal test Hem Check 1 (Veda Lab, France). The subjects were not requested to have any dietary or drug restrictions. Colonoscopy was recommended in all subjects that tested positive.In our study, we had a total of 1389 participants who met the inclusion criteria, with a mean age of 61.2 12.8 years, 565 (40.7%) men and 824 (59.3%) women. FIT was positive in 87 individuals (6.3%). In 57/87 subjects (65.5%) with positive FIT, colonoscopy was performed, while the rest of the subjects refused or delayed the investigation. A number of 5 (8.8%) patients were not able to have a complete colonoscopy, due to neoplastic stenosis. The colonoscopies revealed in 10 cases (0.7%) cancer, in 29 cases (2.1%) advanced adenomas and in 15 cases (1.1%) non advanced adenomas from the total participants in the study. The colonoscopies performed revealed a greater percentage of advanced adenomas in the left colon compared to the right colon, 74.1% vs. 28.6% (p<0.001).In our study, FIT had a positivity rate of 6.3%. The detection rate for advanced neoplasia was 2.8% (0.7% for cancer, 2.1% for advanced adenomas) in our study group. Adherence to colonoscopy for FIT-positive subjects was 65.5%.

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