West Los Angeles Medical Center Los Angeles

Los Angeles, CA, United States

West Los Angeles Medical Center Los Angeles

Los Angeles, CA, United States
SEARCH FILTERS
Time filter
Source Type

PubMed | University of California at Los Angeles, West Los Angeles Medical Center Los Angeles and MR DNA Molecular Research LP Shallowwater
Type: | Journal: Frontiers in physiology | Year: 2015

It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients.This study was to evaluate the effect of the prebiotic xylooligosaccharide (XOS) on the gut microbiota in both healthy and prediabetic (Pre-DM) subjects, as well as impaired glucose tolerance (IGT) in Pre-DM.Pre-DM (n = 13) or healthy (n = 16) subjects were randomized to receive 2 g/day XOS or placebo for 8-weeks. In Pre-DM subjects, body composition and oral glucose tolerance test (OGTT) was done at baseline and week 8. Stool from Pre-DM and healthy subjects at baseline and week 8 was analyzed for gut microbiota characterization using Illumina MiSeq sequencing.We identified 40 Pre-DM associated bacterial taxa. Among them, the abundance of the genera Enterorhabdus, Howardella, and Slackia was higher in Pre-DM. XOS significantly decreased or reversed the increase in abundance of Howardella, Enterorhabdus, and Slackia observed in healthy or Pre-DM subjects. Abundance of the species Blautia hydrogenotrophica was lower in pre-DM subjects, while XOS increased its abundance. In Pre-DM, XOS showed a tendency to reduce OGTT 2-h insulin levels (P = 0.13), but had no effect on body composition, HOMA-IR, serum glucose, triglyceride, satiety hormones, and TNF.This is the first clinical observation of modifications of the gut microbiota by XOS in both healthy and Pre-DM subjects in a pilot study. Prebiotic XOS may be beneficial in reversing changes in the gut microbiota during the development of diabetes.NCT01944904 (https://clinicaltrials.gov/ct2/show/NCT01944904).

Loading West Los Angeles Medical Center Los Angeles collaborators
Loading West Los Angeles Medical Center Los Angeles collaborators