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Culpeper, WV, United States

West Liberty University is a public university in West Liberty, West Virginia, United States, near Wheeling. West Liberty University is West Virginia's oldest institution of higher education. While elementary and secondary education are the most common majors, WLU provides a variety of other programs including digital media design, athletic training, and Appalachian studies. The school's athletic teams, known as the Hilltoppers, compete in the NCAA Division II Mountain East Conference. Wikipedia.

Chae H.-C.,West Liberty University | Koh C.E.,University of North Texas | Prybutok V.R.,University of North Texas
MIS Quarterly: Management Information Systems | Year: 2014

Several studies support the positive link between information technology capability and firm performance, including Bharadwaj (2000) and Santhanam and Hartono (2003), which appeared in MIS Quarterly We conducted a study to see if this link is still statistically significant. It is now over a decade since the first study was published, during which several significant developments in the IT industry have taken place. Unlike the 1990s, when proprietary information systems prevailed, the 2000s are characterized by more standardized and homogeneous information systems and with the rapid adoption of ERP and web technologies. Thus, we attempted to reexamine the link between IT capability and firm performance with data from the 2000s. Surprisingly, the results of our current analysis showed no significant link between IT capability and firm performance. Contrary to earlier studies, IT leader firms in our study didn't show better financial performance than control firms. We discuss several possible causes for the change in findings and present an in-depth comparison in business performance between the two groups-IT leader and control-over a period extending from 1991 to 2007. Source

Lau E.,West Liberty University | Lau E.,Harvard University | Fisher M.C.,Harvard University | Steudler P.A.,The Ecosystems Center | Cavanaugh C.M.,Harvard University
PLoS ONE | Year: 2013

The mxaF gene, coding for the large (α) subunit of methanol dehydrogenase, is highly conserved among distantly related methylotrophic species in the Alpha-, Beta- and Gammaproteobacteria. It is ubiquitous in methanotrophs, in contrast to other methanotroph-specific genes such as the pmoA and mmoX genes, which are absent in some methanotrophic proteobacterial genera. This study examined the potential for using the mxaF gene as a functional and phylogenetic marker for methanotrophs. mxaF and 16S rRNA gene phylogenies were constructed based on over 100 database sequences of known proteobacterial methanotrophs and other methylotrophs to assess their evolutionary histories. Topology tests revealed that mxaF and 16S rDNA genes of methanotrophs do not show congruent evolutionary histories, with incongruencies in methanotrophic taxa in the Methylococcaceae, Methylocystaceae, and Beijerinckiacea. However, known methanotrophs generally formed coherent clades based on mxaF gene sequences, allowing for phylogenetic discrimination of major taxa. This feature highlights the mxaF gene's usefulness as a biomarker in studying the molecular diversity of proteobacterial methanotrophs in nature. To verify this, PCR-directed assays targeting this gene were used to detect novel methanotrophs from diverse environments including soil, peatland, hydrothermal vent mussel tissues, and methanotroph isolates. The placement of the majority of environmental mxaF gene sequences in distinct methanotroph-specific clades (Methylocystaceae and Methylococcaceae) detected in this study supports the use of mxaF as a biomarker for methanotrophic proteobacteria. © 2013 Lau et al. Source

Kraft J.D.,University of South Carolina | Horzempa J.,West Liberty University | Davis C.,University of South Carolina | Jung J.-Y.,University of South Carolina | And 2 more authors.
Immunology | Year: 2013

Microbial infections are a major cause of infant mortality worldwide because of impaired immune defences in this population. The nature of this work was to further understand the mechanistic limitations of the neonatal and infant immune response. Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types. We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults. We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice. Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice. Flow cytometric analysis of intracellular cytokine-stained splenocytes further confirmed these results. Interleukin-27 may be induced during pregnancy to contribute to the immunosuppressive environment at the fetal-maternal interface because we demonstrate dose-responsive gene expression to progesterone in macrophages. Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication. Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes. This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations. © 2013 John Wiley & Sons Ltd. Source

Keir S.T.,Duke University | Saling J.R.,West Liberty University
BMJ Supportive and Palliative Care | Year: 2012

Background: Patients with brain tumours report elevated levels of distress across the disease course. Massage therapy is a commonly used complementary therapy and is employed in cancer care to reduce psychological stress and to improve quality of life (QoL). The purpose of this pilot study was to obtain a preliminary assessment of the effect of massage therapy on patient-reported psychological outcomes and QoL. Materials and methods: This study was a prospective, single-arm intervention. Participants were newly diagnosed primary brain tumour patients who reported experiencing distress and who received a total of eight massages over a period of 4 weeks. Participants completed the National Comprehensive Cancer Network's Distress Thermometer (DT) six times over a 5-week period. Results: As a group, levels of distress dropped significantly between baseline and week 3 (mean 4.19, SD 1.481, p≤0.025), with a further significant reduction in distress between week 3 and week 4 (p≤0.001). At the end of week 4, the DT scores of all participants were below the threshold for being considered distressed. By the end of the intervention, participants reported significant improvements in one test domain focused on emotional well-being. Conclusions: This study further documents that brain tumour patients report high levels of distress across the disease course. However, participants in this study reported improvements in distress level and total number of sources of distress while receiving massage therapy. Source

Loughman Z.J.,West Liberty University
Southeastern Naturalist | Year: 2010

Conservation concerns for imperiled crayfish faunas have recently increased among resource management agencies. In Maryland, major concerns include the introduction of nonnative crayfishes and their impacts on native species. This study documented the species distribution and conservation standing of native and nonnative crayfishes of western Maryland. Native species include Orconectes (Crockerinus) obscurus (Allegheny Crayfish), Cambarus (Jugicambarus) dubius (Upland Burrowing Crayfish), Cambarus (Cambarus) bartonii bartonii (Common Crayfish), and Cambarus (Cambarus) carinirostris (Rock Crawfish). Introduced species are Orconectes (Gremicambarus) virilis (Virile Crayfish), Procambarus (Ortmannicus) acutus (White River Crawfish), and Cambarus (Tubericambarus) thomai (Little Brown Mudbug). Nonnative species were found primarily in areas of high anthropogenic activity, with populations of O. virilis and P. acutus isolated to impoundments. The presence of C. thomai in Maryland was first documented through this study, and represents one of the first situations globally of a primary burrowing crayfish outside of its native range. Major conservation threats to the native crayfish fauna of western Maryland include nonnative crayfishes, land development, and land-use practices. Source

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