Terheyden P.,West Dermatology
Current Opinion in Oncology | Year: 2017
PURPOSE OF REVIEW: Patients with stage IIIB und IV metastatic Merkel cell carcinoma (mMCC), who are not suitable candidates for surgery or radiotherapy, are unlikely to achieve lasting remission or tumor control by chemo or targeted therapy. In the majority of cases, the tumor arises from viral carcinogenesis associated with the Merkel cell polyomavirus (MCPyV). In MCPyV-negative tumors with a presumable ultraviolet carcinogenesis, a high mutational burden resulting in neoantigens was discovered. In two phase II clinical trials in either the first or second-line setting, a high response rate was observed for immunotherapies with antibodies blocking the programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) immune checkpoints. RECENT FINDINGS: The response rate was 56% with the anti-PD-1 inhibitor pembrolizumab as a first-line and 32% with the anti-PD-L1 antibody avelumab used as second-line therapy. Both treatments were well tolerated. Treatment response was rapid and in most cases maintained during follow-up, which, however, is still rather short. Whether the MCPyV or the PD-L1 status is predictive for treatment response and progression-free survival is still ambiguous. Additionally, clinical criteria for patient selection for immunotherapy of mMCC have not yet been defined. SUMMARY: PD-1/PD-L1 inhibition can be regarded as new first-line therapy for patients with mMCC not amendable by surgery and/or radiation. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
News Article | April 26, 2017
Starting at an early age, people are constantly reminded of how beneficial exercise is for the heart, mind, and lungs. However, the board-certified dermatologists at English Dermatology want to remind you that exercise is also good for the skin. Since English Dermatology is an official marketing partner of both the NBA’s Phoenix Suns and the WBNA’s Phoenix Mercury, they know a thing or two about the connection between healthy skin and exercise. “Any time one of our patients says they don’t get much exercise I explain that they’re actually ignoring a crucial aspect of their skin care efforts,” said Paul E. English, MD, FAAD. “Yet, the concept makes perfect sense once you think about it, as exercise and working up a good sweat nourishes your skin and improves your circulation – and anything that helps your blood helps your skin. If you’re going to have toned muscles and a healthy-looking body, why not have skin that’s just as toned, firm, and attractive?” People who don’t regularly exercise sometimes use their skin problems or aversion to sun overexposure as excuses not to work up a sweat. However, research and anecdotal evidence suggest that skin problems can actually improve thanks to exercising. This means that people with eczema or acne, for example, should still exercise regularly, even if they have to cover up or otherwise protect their skin. “Exercise helps alleviate stress, so it can improve eczema, acne, psoriasis, and other skin conditions caused or worsened by stress,” Dr. English said. “Working out gives your skin the nutrients and oxygen it needs, plus perspiration helps carry away waste that clogs your pores or causes irritation. That’s why after a workout, people often look radiant and healthy – just check out your favorite Suns or Mercury player as they leave the arena after a game and you’ll see!” Although exercise can benefit skin, people who have medical or cosmetic skin concerns should still take the time to talk to a board-certified, trained, and experienced dermatologist about them, especially if the impact on everyday life is adverse and troublesome. The staff at English Dermatology has the training, experience, skill, and compassion to help address a variety of skin issues. To learn more about the treatment options, visit http://www.EnglishDermatology.com/Services.html “Skin conditions such as rosacea, acne, or eczema shouldn’t prevent you from getting in a regular workout,” Dr. English said. “Besides, it also reduces stress and even the risk of type II diabetes, which can cause itching, slower healing, and an increased risk of skin infections – which, these days, might be the best reason to work out! So, even if you don’t work out like athletes on the Suns or Mercury do, exercise will get your heart rate up and get the sweat rolling down your skin, delivering all the necessary benefits that healthy skin deserves.” English Dermatology is an affiliate of the West Dermatology network and has locations throughout central Arizona, including offices in San Tan Valley, Gilbert, Ahwatukee, and other areas of greater Phoenix, such as Downtown, Arcadia, and Desert Ridge. The staff of board-certified dermatologists is committed to providing the best, most effective treatments possible to patients of all ages. Each location is equipped with the latest in cutting-edge procedures to address a broad spectrum of dermatological conditions, including medical treatments, surgical procedures, cosmetic solutions, aesthetic services, and more. English Dermatology is the preferred dermatologist for Arizona State University athletics and is an official marketing partner of the Phoenix Suns and Phoenix Mercury. For more information please visit http://www.EnglishDermatology.com
News Article | February 28, 2017
Las Vegas Skin and Cancer Clinic (LVSCC) is proud to announce the grand reopening of its revamped South Rancho location on Friday, March 10, 2017, 4-7 pm PST. For more than six decades, LVSCC has provided the Las Vegas community with expert dermatological care, but this clinic, located in the South Rancho neighborhood, has been renovated to provide medical and cosmetic dermatological products and services. Patients at the newly renovated South Rancho location will have access to cutting-edge technology, superior customer service, and an unsurpassed staff of top dermatology doctors and medical professionals. LVSCC is also a member of the West Dermatology network of practices, which includes multiple locations throughout California, Nevada, and Arizona. “We chose to renovate this particular location because we wanted to maintain our Las Vegas identity and give back to the South Rancho community that has been so good to us,” Chris Kane, CEO of LVSCC and West Dermatology said. “In our 62 years of service, we’re proud that both our services and our locations have grown in number. This would not be possible without the support of the Las Vegas community or without the commitment of the excellent doctors and medical professionals on our staff.” The South Rancho clinic reopening ceremony will include several of the staff doctors who will meet with members of the local community to discuss their skin care needs. Among the doctors expected to attend are Dr. Paul English, Dr. Lucius Blanchard, Dr. Clifton Hall, Dr. Frederick Herman, Dr. Brent D. Michaels, and Dr. Mitchel Goldman. Along with the rest of the fine staff, they will provide a wide range of treatments and services for both medical and cosmetic dermatological conditions. “The Rancho office is a prime area for our patients, that has been around for over 20 years. I look forward to seeing what the future holds for this clinic alongside West Dermatology,” added Dr. Lucius Blanchard, Nevada Medical Director. “The doctors on our staff are board-certified dermatologists with the experience, skills, and training to address such issues as skin cancer and other medical dermatological issues,” Mr. Kane said. “Additionally, we have an allergist on staff with Dr. Frederick Herman. He specializes in allergies and immunological concerns in addition to his dermatology expertise; in fact, he’s the only psoriasis specialist within 300 miles.” LVSCC/West Dermatology is the leading dermatology clinic network in the country, and, in renovating this South Rancho location, they hope to show their continued commitment to serving the Las Vegas community. The clinic will adhere to the LVSCC/West motto of “love your skin” with the latest, most effective products and services for skin conditions ranging from skin cancer and psoriasis to acne and wrinkle reduction. To learn more about the clinic as well as the ribbon-cutting ceremony on March 10, 2017, visit http://WestDermatology.com/Las-Vegas-Skin-Cancer/. “We’re excited to open this renovated clinic and provide the local community with the best dermatological products, services, and care on the West Coast,” explained Mr. Kane. “Our passion is to serve our patients and our goal is to build a lasting bond with the community. We invite everyone out to our ribbon-cutting ceremony on Friday, March 10, 2017, 4-7 pm. We hope to see you then and there, but if not, stop by and visit the location after that date for all of your skin care needs and concerns.” For more than 60 years, LVSCC/West has been providing patients with the best treatment possible through a combination of expertise, compassion, convenience, and comprehensive care. Through multiple locations across the West Coast in California, Nevada, and Arizona, West Dermatology offers a network composed of millions of patients with 24/7 access to doctors, records, and bill payment. For more information please visit http://www.WestDermatology.com.
News Article | March 2, 2017
ORLANDO, Fla., March 02, 2017 (GLOBE NEWSWIRE) -- Lumenis Ltd., the world’s largest energy-based medical device company for surgical, aesthetic, and ophthalmic applications, proudly announces its 50th anniversary, which will be celebrated at the American Academy of Dermatology (AAD) Annual Meeting in Orlando, FL from March 3rd – 7th, 2017. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/3baec13a-7846-496f-95c9-3b6aa5206bed As an international leader in the development and commercialization of innovative aesthetic energy-based technologies, Lumenis has invented Intense Pulsed Light (IPLTM) for skin treatments, LightSheer® – diode laser for hair removal and the UltraPulse® – the most powerful CO laser in aesthetic medicine, among many others. Lumenis has redefined medical treatments and set numerous technological and clinical gold standards. The company has successfully created solutions for previously untreatable conditions, as well as designed advanced technologies that have revolutionized existing treatment methods. “When we were the first to develop the IPL in the 1990s, it was not clearly understood how a pulsed broadband non-laser energy source could treat specific chromophore targets, but through the years it has proven to be one of the most versatile technologies on the market. The invention of these laser and light-based approaches for dermatology- opened up my practice for a whole new set of aesthetic indications [that] I never had a good solution for. Now I can’t do [it] without them,” said Dr. Mitchel P. Goldman, from Cosmetic Laser Dermatology, San Diego, Medical Director for West Dermatology and a former Medical Director at Lumenis. Dr. Goldman is a guest speaker at the AAD. Lumenis’ vision is to provide better technology for better patient care through innovative energy-based solutions. With a ground-breaking technological legacy of five decades, the company is committed to enhancing patient health and quality of life, addressing new and growing needs of the aging population, and continuing to offer medical professionals innovative solutions to meet the developing and dynamic healthcare environment of the 21st century. “Lumenis is proud to provide advanced noninvasive solutions from the most common to the most severe skin concerns,” said Tzipi Ozer-Armon, CEO of Lumenis. “As we have for the past 50 years, Lumenis is committed to continue supporting medical community leaders advancing the use of medical laser technologies and providing innovative, life-changing treatment benefits.” In an effort to serve underprivileged and underserved populations, Lumenis has partnered with a number of foundations, hospitals, and healthcare professionals internationally, with countries including Haiti, Russia, St. Lucia, India, Africa, and Armenia, to provide the latest energy-based treatments to patients suffering from conditions such as BPH, burn injuries, and glaucoma. Lumenis lasers are used in humanitarian missions around the world to treat wounded warriors, war survivors, and severe scar patients, including Kim Phuc, a survivor of the Vietnam War bombing who is recognized as “The Girl in the Picture.” Lumenis lasers improve the quality of life of many patients around the world, such as cancer survivor, Angela Wissel, who is also speaking at the AAD. “The FemTouch procedure was absolutely life changing. I couldn’t believe the difference in just a short amount of time, and we had our life back – literally. It was amazing,” said Wissel. “The treatments are quick, they are painless, they’re easy, and I wish I had known about this instead of suffering for years waiting for a solution.” Lumenis will honor its 50th anniversary and decades of innovation at this year’s AAD with a champagne celebration. Please visit lumenis.com for a detailed agenda of activities at the conference. For more information about the Lumenis family of products, please visit the Lumenis booth (#2541), where attendees can win prizes for answering fun quiz questions about laser history. About Lumenis Lumenis is a global leader in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology, and Aesthetic markets, and is a world-renowned expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). For 50 years, Lumenis' ground-breaking products have redefined medical treatments and have set numerous technological and clinical gold-standards. Lumenis has successfully created solutions for previously untreatable conditions, as well as designed advanced technologies that have revolutionized existing treatment methods. For more information visit: www.lumenis.com Forward-Looking Statements Information provided in this press release may contain statements relating to current expectations, estimates, forecasts and projections about future events that are forward-looking statements. These forward-looking statements may include but are not limited to the Company's plans, objectives and expectations for future operations, including its projected results of operations. Forward-looking statements are often characterized by the use of forward-looking terminology such as “may,” “will,” “expect,” “anticipate,” “estimate,” “continue,” “believe,” “should,” “intend,” “plan,” “project” or other similar words, but are not the only way these statements are identified. These forward-looking statements are based upon our management's current estimates and projections of future results or trends. Actual results may differ materially from those projected as a result of certain risks and uncertainties These forward-looking statements are made only as of the date hereof, and the Company undertakes no obligation to update or revise the forward-looking statements, whether a result of new information, future events or otherwise.
Valdes A.M.,King's College London |
Valdes A.M.,University of Nottingham |
Glass D.,King's College London |
Glass D.,West Dermatology |
Spector T.D.,King's College London
Nature Reviews Genetics | Year: 2013
Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age. © 2013 Macmillan Publishers Limited. All rights reserved.
Sarma N.,West Dermatology
Indian Journal of Dermatology, Venereology and Leprology | Year: 2013
Hand, foot, and mouth disease (HFMD), first reported in New Zealand in 1957 is caused by Coxsackievirus A16 (CVA16) and human enterovirus 71 (HEV71) and occasionally by Coxsackievirus A4-A7, A9, A10, B1-B3, and B5. This is characterized by erythematous papulo vesicular eruptions over hand, feet, perioral area, knees, buttocks and also intraorally mostly in the children. HFMD has been known for its self limiting course. Only small scale outbreaks have been reported from United States, Europe, Australia, Japan and Brazil for the first few decades. However, since 1997 the disease has conspicuously changed its behavior as noted in different Southeast Asian countries. There was sharp rise in incidence, severity, complications and even fatal outcomes that were almost unseen before that period. Following the near complete eradication of poliovirus, HEV71, the non-polio enterovirus, may become the greatest threat to cause significant neurological complications. This adds to the fact that effective therapy or vaccine is still a far reaching goal. There are reports of disease activity in different corners of India since 2004. Although of milder degree, continuous progress to affect larger parts of the country may indicate vulnerability of India from possible future fatal outbreaks. Low level of awareness among the health care providers may prove critical.
Zip C.M.,West Dermatology
Dermatologic Clinics | Year: 2010
Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties. It was the first topical therapy approved solely for rosacea and remains a cornerstone of rosacea management. This article reviews the optimal use of topical metronidazole in the treatment of rosacea and other innovative but off-label dermatologic uses reported in the literature. © 2010 Elsevier Inc.
Scheinfeld N.,West Dermatology
Clinics in Dermatology | Year: 2015
Hidradenitis Suppurativa (HS) is an uncommon disease, which is particularly rare in young and prepubescent children. HS pathology centers on the follicular unit and involves aberrant cutaneous cellular immunity. HS tends to first manifest in puberty, but a handful of prepubescent cases of HS have been reported and are linked to hormonal disorders, in particular elevated testosterone. The most common manifestations of HS are abscesses, scarring, acne inversa, and keloids, especially in the intertriginous areas of the groin and the axilla. Treatments including topical anti-infectives including chlorhexidine wash, topical clindamycin, tretinoin cream, and azelaic acid cream, which may be of limited use because bacteria involved in HS likely create biofilms. Oral agents include clindamycin with or without rifampin for short-term usage. Cases resistant to conservative therapy have been reported to respond to finasteride, onabotulinumtoxin, or microfractionated 10,600-nm CO2 laser. © 2015.
Tollefson M.M.,West Dermatology
Pediatric Clinics of North America | Year: 2014
Psoriasis is increasing in both children and adults. The association of comorbidities, specifically obesity and other components of the metabolic syndrome, are also increasing. The precise cause is unknown but genetic and complex immunologic factors play a role in the development of the disease and its comorbidities. There are multiple clinical variants, and the severity of the disease can range from mild localized lesions in most patients to severe generalized involvement in some. Most patients with mild to moderate disease can be controlled with topical treatments. © 2014 Elsevier Inc.
Rose P.T.,West Dermatology
Facial Plastic Surgery | Year: 2011
Hair restoration began as a result of the fortuitous finding by Dr. Norman Orentreich that hair follicles taken from an area of nonbalding scalp could be implanted into an area of male pattern hair loss and continue to grow terminal hair. Since that time, hair transplants have progressed from the use of large plugs to the use of follicular units (normally occurring clusters of hairs). This has allowed surgeons to create undetectable results in cases of androgenetic alopecia and well as other conditions associated with hair loss. Advances continue in hair restoration technique ranging from surgical approach to instrumentation and ways to enhance growth. In this article, the more recent surgical and medical innovations in hair reconstruction are reviewed. Copyright © 2011 by Thieme Medical Publishers, Inc.