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Middletown, CT, United States

Wesleyan University is a private liberal arts college in Middletown, Connecticut, United States, founded in 1831. Wesleyan is a Baccalaureate College that emphasizes undergraduate instruction in the arts and science, provides graduate research in many academic disciplines, and grants PhD degrees primarily in the science and mathematics. Wesleyan is the second most productive liberal arts college in the United States with respect to the number of undergraduates who go on to earn PhDs in all fields of study.Founded under the auspices of the Methodist Episcopal Church and with the support of prominent residents of Middletown, the now secular university was the first institution of higher education to be named after John Wesley, the founder of Methodism. About 20 unrelated colleges and universities were subsequently named after Wesley. Wesleyan, along with Amherst College and Williams College, is a member of the Little Three colleges. Wikipedia.

Kurtz M.M.,Wesleyan University
Expert Review of Neurotherapeutics | Year: 2012

Cognitive remediation (CR) is an increasingly studied behavioral intervention for improving illness-linked cognitive deficits in schizophrenia, with considerable promise for improving the disease outcome when offered in concert with other therapies. We present findings from a comprehensive, critical review of the extant literature on CR for schizophrenia. Conclusions from six meta-analyses presented to date are summarized, and existing CR interventions are categorized into three major classes: restorative, strategy-based and hybrid approaches. The crucial elements and empirical support for each class are presented. Studies of predictors of treatment response suggest that attention, motivation and clinician expertise, along with the measures of 'brain reserve', are key features of a positive treatment response. Lastly, findings from studies of neuroimaging indicate that CR is accompanied by structural and functional neural changes in key frontal and temporal brain regions. © 2012 Expert Reviews Ltd. Source

Starr F.W.,Wesleyan University | Douglas J.F.,U.S. National Institute of Standards and Technology
Physical Review Letters | Year: 2011

We investigate the impact of nanoparticles (NP) on the fragility and cooperative stringlike motion in a model glass-forming polymer melt by molecular dynamics simulation. The NP cause significant changes to both the fragility and the average length of stringlike motion, where the effect depends on the NP-polymer interaction and NP concentration. We interpret these changes via the Adam-Gibbs (AG) theory, assuming the strings can be directly identified with the abstract "cooperatively rearranging regions" of AG. Our findings indicate that fragility is primarily a measure of the temperature dependence of the cooperativity of molecular motion. © 2011 American Physical Society. Source

Sultan S.E.,Wesleyan University
Current Opinion in Plant Biology | Year: 2010

Evolutionary ecology and developmental biology have converged on the key insight that phenotypic expression is powerfully conditioned by environmental information. Plant ecological development (eco-devo) aims to firstly, determine precisely how plants perceive and respond to the varying environmental conditions they encounter in the real world and secondly, understand the ecological and evolutionary consequences of environmentally mediated phenotypic outcomes. This full explanatory scope, from molecular interactions to natural populations and communities, is just now being realized for two adaptively important aspects of developmental response: shade avoidance and flood tolerance. These and other new findings point to the complex, interactive nature of both environmental cues and gene-regulatory networks, and confirm the importance of incorporating realistic environmental variation into studies of development. © 2009 Elsevier Ltd. All rights reserved. Source

MacQueen A.J.,Wesleyan University | Hochwagen A.,Whitehead Institute For Biomedical Research
Trends in Cell Biology | Year: 2011

The coordinated execution of cell cycle processes during meiosis is essential for the production of viable gametes and fertility. Coordination is particularly important during meiotic prophase, when nuclei undergo a dramatic reorganization that requires the precise choreography of chromosome movements, pairing interactions and DNA double-strand break (DSB) repair. Analysis of the underlying regulatory mechanisms has revealed crucial and widespread roles for DNA-damage checkpoint proteins, not only in cell cycle surveillance, but also in controlling many processes uniquely characteristic of meiosis. The resulting regulatory network uses checkpoint machinery to provide an integral coordinating mechanism during every meiotic division and enables cells to safely maintain an error-prone event such as DSB formation as an essential part of the meiotic program. © 2011 Elsevier Ltd. Source

Hingorani M.M.,Wesleyan University
DNA Repair | Year: 2016

The focus of this article is on the DNA binding and ATPase activities of the mismatch repair (MMR) protein, MutS-our current understanding of how this protein uses ATP to fuel its actions on DNA and initiate repair via interactions with MutL, the next protein in the pathway. Structure-function and kinetic studies have yielded detailed views of the MutS mechanism of action in MMR. How MutS and MutL work together after mismatch recognition to enable strand-specific nicking, which leads to strand excision and synthesis, is less clear and remains an active area of investigation. © 2015 Elsevier B.V. Source

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