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Boston, MA, United States

The Wentworth Institute of Technology is an independent, co-educational, technical design and engineering college located in Boston, Massachusetts. Wentworth was founded in 1904 and offers career-focused education through its fifteen bachelor's degree programs in areas such as architecture, computer science, design, engineering, engineering technology, and management, as well as Masters degrees in architecture and construction management. Wentworth is one of six institutions of higher learning known collectively as the Colleges of the Fenway. The university is one among a small group of Institute of Technologies in the United States which tend to be primarily devoted to the instruction of technical arts and applied science. Wikipedia.


Talpasanu I.,Wentworth Institute of Technology
Journal of Mechanisms and Robotics | Year: 2015

The paper presents a novel and simple technique for the kinematic analysis of bevel gear trains (BGT). The approach is based on edge-oriented graphs for efficient computation of BGT's absolute and relative velocities of links using incidence matrices. The kinematic equations are generated in matrix form using a cycle basis from a cycle matroid. The set of independent equations is automatically obtained from matrix orthogonalities and not by taking derivatives. Equation coefficients are expressed as function of speed ratios and have minimal variables. Then the relationships between the output and input angular velocities can be determined. In addition, a simple procedure is demonstrated to check for mechanism singularities. The method presented here has general applicability and can be employed for spatial geared mechanisms with any number of gears and degrees of freedom (DOF) as illustrated by numerical examples of robotic wrist mechanisms. © 2015 by ASME. Source


Ngan C.-H.,Boston University | Hall D.R.,Boston University | Zerbe B.,Boston University | Grove L.E.,Wentworth Institute of Technology | And 2 more authors.
Bioinformatics | Year: 2012

Motivation: Binding site identication is a classical problem that is important for a range of applications, including the structure-based prediction of function, the elucidation of functional relationships among proteins, protein engineering and drug design. We describe an accurate method of binding site identication, namely FTSite. This method is based on experimental evidence that ligand binding sites also bind small organic molecules of various shapes and polarity. The FTSite algorithm does not rely on any evolutionary or statistical information, but achieves near experimental accuracy: it is capable of identifying the binding sites in over 94% of apo proteins from established test sets that have been used to evaluate many other binding site prediction methods. © The Author 2011. Published by Oxford University Press. All rights reserved. Source


Mannheim P.D.,University of Connecticut | O'Brien J.G.,Wentworth Institute of Technology
Journal of Physics: Conference Series | Year: 2013

We review some recent work by Mannheim and O'Brien on the systematics of galactic rotation curves in the conformal gravity theory. In this work the conformal theory was applied to a comprehensive, high quality sample of spiral galaxies whose rotation curves extend well beyond the galactic optical disks. On galactic scales the conformal gravitational theory departs from the standard Newtonian theory in two distinct ways. One is a local way in which local matter sources within galaxies generate not just Newtonian potentials but linear potentials as well. The other is a global way in which two universal global potentials, one linear the other quadratic, are generated by the rest of the matter in the universe. The study involves a broad set of 138 spiral galaxies of differing luminosities and sizes, and is augmented here through the inclusion of an additional three tidal dwarf galaxies. With its linear and quadratic potentials the conformal theory can account for the systematics of an entire 141 galaxy sample without any need for galactic dark matter, doing so with only one free parameter per galaxy, namely the visible galactic mass to light ratio. Source


O'Brien J.G.,Wentworth Institute of Technology | Mannheim P.D.,University of Connecticut
Monthly Notices of the Royal Astronomical Society | Year: 2012

We continue our study of the application of the conformal gravity theory to galactic rotation curves. Previously we had studied a varied 111 spiral galaxy sample consisting of high surface brightness galaxies, low surface brightness galaxies and dwarf galaxies. With no free parameters other than galactic mass-to-light ratios, we had found that the theory is able to account for the systematics that are observed in the entire set of galactic rotation curves without the need for any dark matter whatsoever. In this paper, we extend our study to an additional set of 27 galaxies of which 25 are dwarf galaxies, and provide updated studies of three additional galaxies that had been in the original sample, and again without dark matter find fully acceptable fits, save only for just a few galaxies that we find to be somewhat troublesome. Our current study brings to 138 the number of rotation curves of galaxies that have been accounted for by the conformal gravity theory. Since one of the primary ingredients in the theory is a universal contribution to galactic motions coming from matter exterior to the galaxies, and thus independent of them, our study reinforces one of the central concepts of the conformal gravity studies, namely that invoking dark matter should be viewed as being nothing more than an attempt to describe global physics contributions in purely local galactic terms. © 2012 The Authors Monthly Notices of the Royal Astronomical Society © 2012 RAS. Source


Grove L.E.,Wentworth Institute of Technology
Bioinformatics (Oxford, England) | Year: 2013

Computational solvent mapping finds binding hot spots, determines their druggability and provides information for drug design. While mapping of a ligand-bound structure yields more accurate results, usually the apo structure serves as the starting point in design. The FTFlex algorithm, implemented as a server, can modify an apo structure to yield mapping results that are similar to those of the respective bound structure. Thus, FTFlex is an extension of our FTMap server, which only considers rigid structures. FTFlex identifies flexible residues within the binding site and determines alternative conformations using a rotamer library. In cases where the mapping results of the apo structure were in poor agreement with those of the bound structure, FTFlex was able to yield a modified apo structure, which lead to improved FTMap results. In cases where the mapping results of the apo and bound structures were in good agreement, no new structure was predicted. FTFlex is freely available as a web-based server at http://ftflex.bu.edu/. Source

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